Ferritin may be associated with glucose metabolism disorders and metabolic syndrome even in people without hepatic steatosis or hepatic iron overload.
Hepatic steatosis and hepatic iron overload modify the association of iron markers with glucose metabolism disorders and metabolic syndrome (open access)
doi.org/10.1111/liv.14…
#MetabolicSyndrome #NAFLD #diabetes #InsulinResistance #nutrition #diet
doi.org/10.1111/liv.14…
#MetabolicSyndrome #NAFLD #diabetes #InsulinResistance #nutrition #diet
- "serum ferritin concentrations were associated with higher prevalence of IGM, T2DM and MetS as well as higher levels of fasting glucose, 2-h glucose, 2-h insulin, HOMA-IR and HbA1c in the total population independent of inflammatory markers and hepatic enzymes...
"...The association of ferritin with IGM and T2DM were more pronounced in women, while the association with MetS was more pronounced in men. Further, serum ferritin was associated with T2DM and MetS even in the absence of hepatic steatosis...
"...However, the synergistic effect of higher ferritin concentrations and hepatic steatosis showed stronger associations with IGM, T2DM and MetS than the effects of ferritin alone...
"...Similarly, while serum ferritin was associated with IGM, T2DM and MetS even in the absence of iron overload, the synergistic effect of higher ferritin concentrations and hepatic iron overload showed stronger associations with IGM and T2DM than the single effects of ferritin"
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