"we observed significant associations with insulin secretion. Notably, C-peptide based indices were positively, but insulin-based ones were negatively associated with LDL cholesterol. This was due to an association of LDL cholesterol with insulin clearance."
Low-density lipoprotein cholesterol is associated with insulin secretion (open access)
doi.org/10.1210/clinem…
#nutrition #diet #MetabolicSyndrome #cholesterol #BloodSugar
doi.org/10.1210/clinem…
#nutrition #diet #MetabolicSyndrome #cholesterol #BloodSugar
- "We detected a significant, positive association between fasting LDL concentrations and C-peptide based estimates for insulin secretion...
"...As these indices reflect insulin secretion independent of hepatic clearance, they are the superior estimates of insulin secretion in our current setting...
"...Our results indicate that higher LDL cholesterol levels could promote insulin secretion from pancreatic ß-cells...
"...Of note, potential LDL effects on insulin secretion appear to be affected by glucose control and seem to be blunted in prediabetes and diabetes"
- "fasting and stimulated insulin clearance were both directly associated with LDL concentrations...
"...Accordingly, with increasing LDL cholesterol concentrations, more insulin is extracted by the liver, explaining the inverse correlation of insulin-based and C peptide-based estimates for insulin secretion...
"...We therefore hypothesize that hepatic mechanisms that decrease circulating LDL cholesterol levels, concurrently enhance the liver’s insulin clearance capacity"
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