Following in our sequence from the S-T & K paper on SFA, the next paper is the Framingham study nutritional analysis from Posner. Of note, Framingham did not initially include a dietary component.
The study began in 1948 and the first food interviews didn't happen until 1954. These were a combination of 24 hour recall and FFQ. This study, published in 1991 controlled for serum cholesterol, yet still found SFA was linked to CHD. jamanetwork.com/journals/jamai… 
So if you are keeping score, of the first four papers used by S-T & K to show no link between SFA and CHD, all four found a link between SFA and CHD, and the percent calories from SFA was a strong predictor of risk between populations with high consumption vs. low consumption.
Additionally, using Framingham data, which controlled for cholesterol and had huge numbers, will blunt the true effect of SFA in a meta-anlaysis if you accept the well-established notion that SFA causes CHD by raising total and LDL cholesterol.
To control for cholesterol when studying SFA, leaves only the additive effects of SFA, separate from their main effect in causing the disease by raising LDL. The fact that most studies that control for cholesterol still manage to show negative effects is hardly reassuring.
Tomorrow I'll take a look at the Caerphilly study, a Welsh look at CHD.
