Discover and read the best of Twitter Threads about #TLDR

Most recents (24)

Really chuffed to share our latest work from Sanjana Lab out in @nature today (nature.com/articles/s4158…).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.

A thread...
(2/28) T cell therapies have shown the potential to cure patients from #cancer – but even in B cell cancers, relapses outnumber cures… One of the problems is limited T cell persistence. #celltherapy #CARTcell
(3/28) We wanted to find new genes (including genes never expressed in T cells) that could improve T cell persistence. Now, the question was: should we use #crispr activation or directly deliver target genes on a #lentivirus?
Read 30 tweets
1/n It seems that these are trying times in #Ukraine at the moment, for those in that country with a slightly dark sense of humour this #Discworld reading list may be morale building & also informative in your current situation
2/n #GNUTerryPratchett also has a range of books more suitable to the younger reader & may also be a good distraction if you can get hold of them in your current situation see full reading list below.
3/n The real point of this thread is to get some ideas to @DefenceU & people of #Ukraine on how to #StopTheWar by persuading the Russians currently in #Ukraine to cease their actions & go home, by the very careless use of words to paint a vivid picture of some of their possible
Read 165 tweets
LOL prepping for @gregoryawilson presentation to his students tomorrow on writing as an #SFFPoet from the SEA Diaspora & his poor students are going to run into so many tangents on my twitter this week. SORRY, KIDS. But for sure, start here at least:
@gregoryawilson The @SahtuPress study guide is really an initial consolidated start for students doing full research projects on my work. I find it a bit #TLDR but it is useful: sahtu.press/articles/2022-…
The Wikipedia entry on my work is mostly up to date:

en.wikipedia.org/wiki/Bryan_Tha…
Read 7 tweets
Last two days, we went through the context of this opportunity to explore #BuildingaBetterEconomy and the current state of the world. Today we are going to do a #causaanalysis of this state. #Chapter3
Capital Accumulation is a function of the below parameters
- A systematic risk and skewed incentives in the system.
- A gaping problem with modern econ theories and modern financial systems.
- Centralization of data/information with powerful tools to exploit them.
1. Between March 18, 2020, and April 12, 2021, the collective wealth of American billionaires leaped by $1.62 trillion, or 55%, from $2.95 trillion to $4.56 trillion. The reference here: docs.google.com/spreadsheets/d…
Read 86 tweets
1/Ik zie heel veel ruzie hier over aantallen gevaccineerden versus ongevaccineerden. Mensen die elkaar beschuldigen van rekenfouten en verkeerde conclusies. Hoe zit het nou? Is het 50/50? of worden gevaccineerden veel minder vaak ernstig ziek?
Een🧵.
#tldr: beiden hebben gelijk.
2/Hoe kan dat? Nou, het hangt er maar van af welke vraag je stelt.

Allereerst deze vraag: heeft het zin om je te laten vaccineren als de helft van de ziekenhuispatiënten toch gevaccineerd blijkt?
3/Antwoord: ja. Want er zijn veel meer gevaccineerden dan ongevaccineerden (7 a 8 keer zo veel), dus als het vaccin zinloos was om te voorkomen dat je ernstig ziek wordt, zou je ook 7 a 8 keer zoveel gevaccineerden met covid in het ziekenhuis verwachten.
Read 22 tweets
Nogmaals het Corona-wat-vandaag-gebeurt-heeft-over-3weken-gevolgen draadje. Nu uitgewerkt.
#tldr:
Vandaag 12700 nieuwe #covid19 gevallen betekent:
- over 10 dagen 300 opnames ziekenhuis (per dag)
- over 15 dagen 60 opnames IC (per dag)
- over 20 dagen 50 doden (per dag)
1/9
Dan even uitgewerkt. In bovenstaande grafiek staan de berekeningen van de effect rekening houdend met de bekende vertraging. Dus eerst bovenste grafiek. Tussen 1e ziektedag en opname ziekenhuis ligt gemiddeld 10 dagen.
2/9
Bij ontwikkeling laatste weken gaat 2,3% van positieve gevallen na 10 dagen naar ziekenhuis. 2,3% van 12700 = 300.
De vertraging vanaf ziek worden tot IC is ongeveer 15 dagen. De middelste lijn geeft daar het percentage dan weer van aan.
3/9
Read 11 tweets
Huomentapäivää! Tervetuloa twitter-luennolle. Tässä ketjussa käydään läpi TAKO-seminaarissa pitämäni esitelmä, jossa selviää missä saa kuvata.
Kuvaamista koskeva lainsäädäntö on suhteellisen simppeliä. Käydään ensin läpi muutama asia, jotka jokaisen kuvaajan tulisi tietää.
Jos haluat tiivistelmän tästä esitelmästä, se on tämä: Suomessa julkisella paikalla saa aina kuvata. #tldr
Read 24 tweets
Ok, my undergraduate bridge session adapting @callin_bull materials by @CT_Bergstrom and @JevinWest is prepped for Monday. Here's a thread of what I have planned in case wants to do something similar 1/20
The #TLDR piece of advice is to visit callingbullshit.org and look at the case studies and youtube recordings 2/20
For context, this bridge session is part of an NSF-funded Improving Undergraduate STEM Education (Hispanic-serving Institutions) grant awarded to @DominicanU. Here's a webpage about the overall project: dom.edu/academic-succe… 3/20
Read 22 tweets
👉 Lessons I learned on & about #MedTwitter

A 🧵 about my journey exploring what’s beyond being #professional as a 🩺 #SoMe user

#TLDR: Aim for fulfilled & happy & kind ➕ a healthier 🪢 with technology 📱💻
🤔 why I made this 🧵?

I was asked to give a talk: 'How to be professional on social media' at #ESPNIC2021 for #YoungESPNIC and other participants of the congress

❗️But I felt we could be aiming for so much more than #Professional

So here we are👇
Experts talk about #SoMe as a non-binary thing: it isn’t like you use it or not, because it’s already everywhere. Others say it is actually harder to ignore it.

👥 If you come aboard, do it mindfully
⛔️ Staying out intentionally is an option
⚠️ Avoid the half-in/half-out state
Read 24 tweets
🚨 What are the political consequences of pandemics? 🚨

D. Gingerich & I analyze history’s deadliest #pandemic in a brand new @World_Pol article: “Pandemics & Political Development: The Electoral Legacy of the #BlackDeath in Germany”

doi.org/10.1017/S00438…

#polisciresearch 🧵 Image
Brief summary (#TLDR): The Black Death (BD) had a significant long-term impact on Germany’s political development. Hard-hit areas introduced proto-democratic institutions; sustained experiences with participative government later helped reject antidemocratic & illiberal parties. Image
Long overview (starting here): In 1347, Europe was hit by a pandemic that killed 30–60% of its population: the BD. It had a major impact on medieval society which was based on feudalism/serfdom. Yet the BD’s impact varied greatly across space, leading to divergence in its impact. Image
Read 19 tweets
THREAD 1/n: @merrionstreet @Dept_ECC: does the proposed new Irish climate action law actually, legally, COMMIT to stringent GHG emissions reduction over the period 2021-2030? (#spoileralert: “Probably not.”)
2/n: The IE Govt claims explicitly that “few, if any, countries have legislated for as steep an emissions reduction” as required by this bill: irishtimes.com/news/politics/…
3/n: However: Prof John Sweeney, @AndrewLRJackson and I wrote to the Govt on 14th April pointing out that the relevant section of the Bill (inserting a new s. 6A(5) in the existing 2015 Act) was defective in both law and science: docs.google.com/a/dcu.ie/viewe…
Read 14 tweets
[Short? thread 1/n] The new Irish Climate Action Bill is now in Select Committee stage. The full list of proposed amendments is here: data.oireachtas.ie/ie/oireachtas/…
[2/n] Dedicated followers [?] will recall that I, together with Prof. John Sweeney and @AndrewLRJackson previously raised significant concerns about the way the "2021-2030 interim target" was being transposed into the Bill:
[3/n] #TLDR: the 2020 Programme for Government committed to "to an average 7% per annum reduction in overall greenhouse gas emissions from 2021 to 2030 (a 51% reduction over the decade)". Govt subsequently agreed to put this on a binding statutory basis via the new Bill...
Read 12 tweets
Now you know all the things #AdamSmith has to say about what the government should spend money on. But that money's gotta come from somewhere. What does #WealthOfNations say about how governments should get money to spend? (V.ii.) #WealthOfTweets #SmithTweets
I know the tax nerds have been waiting for this chapter (we ❤ you, nerds), but first Smith wants to talk about other sources of revenue "which may peculiarly belong to the Sovereign or Commonwealth". (V.ii.a) #WealthOfTweets #SmithTweets
IOW, before we get to taxes we've gotta cover businesses run by the sovereign (like the post office), public banks, public lending, and revenue from public lands.

But don't worry, we can do that pretty quickly...ish. (V.ii.a) #WealthOfTweets #SmithTweets
Read 17 tweets
BUT WHAT ABOUT THE ROADS?
Yes, #adasmSmith says sovereigns should also maintain public institutions and public works that are good for society but that people won’t pay for on their own. (V.i.c.1) #WealthOfTweets #SmithTweets
And yes, this category of expenses includes education, about which more later. We promise. (V.i.c.1) #WealthOfTweets #SmithTweets
The first kind of public works Smith is concerned with are the kind that facilitate commerce in general. Like ROADS. (V.i.d.1) #WealthOfTweets #SmithTweets
Read 36 tweets
Yesterday #AdamSmith outlined the first duty of the sovereign—protecting the nation from attack. The second duty of the sovereign is protecting individuals from each other aka administering justice. (V.i.b.1) #WealthOfTweets #SmithTweets
Just as defense gets more complicated and expensive as societies develop, so does the process of administering justice. (V.i.b.1) #WealthOfTweets #SmithTweets
In nations of hunters, where there is little private property, there’s little need for complex justice. We may do violence to each other out of anger or other passions, but we really don’t give in to that very often. (V.i.b.2) #WealthOfTweets #SmithTweets
Read 34 tweets
It's been a whole day since we tweeted Part 2 of this chapter, so let us remind you: #AdamSmith just said that the colonies got nothing that helped them succeed from the mother country. (IV.vii.c) #WealthOfTweets #SmithTweets
So these two opening sentences are pretty heckin’ sarcastic:
Now we've seen the great advantages the colonies got (they got nothing!) (IV.vii.c.1)
So what have been the great advantages to Europe! (IV.vii.c.2)

Seems like there’s a...tone there. #WealthOfTweets #SmithTweets
Europeans buy goods from America, and Americans buy European goods as well. Even countries that don’t trade directly with America have benefited. (IV.vii.c.3–8) #WealthOfTweets #SmithTweets
Read 28 tweets
Dear Smithketeers. Over many chapters of #WealthOfNations, we've grown close. We were even going to ask all of you to be our Valentines.
And we have to tell you:

The title of Book IV Chapter 6, "Of Treaties of Commerce", is a lie. (IV .vi) #WealthOfTweets #SmithTweets
More like, "Of the reasons the Author is opposed to Treaties generally and the Treaty with Portugal in particular." (IV .vi) #WealthOfTweets
But FINE. Here we go:

Countries that bind themselves via a treaty to offer special treatment to the merchants and manufacturers of another country are granting them a sort of monopoly over their market. (IV. vi.1) #WealthOfTweets #SmithTweets
Read 22 tweets
#AdamSmith, #WealthOfNations, and #CornLaws!
What more could you possibly want on a Saturday morning? (IV.v.b) #WealthOfTweets #SmithTweets
Yes, it’s the Digression Concerning the Corn Trade and Corn Laws! We can barely contain ourselves long enough to remind you that “corn” doesn’t mean 🌽 It means the principal cereal crop of a nation. (We keep saying so because we keep forgetting.) #WealthOfTweets #SmithTweets
#TLDR on #AdamSmith’s thoughts on the Corn Laws:

They’re bad. (IV.v.b.1) #WealthOfTweets #SmithTweets
Read 29 tweets
Today #AdamSmith is talking about stuff that sounds pretty contemporary. But remember: it's 240 years old. Today it's all about attempts by the political system to manipulate the balance of trade. (IV.iii.) #WealthOfTweets #SmithTweets
The "Commercial System" that Smith is talking about here is also called the mercantile system, or mercantilism. (IV.iii.) #WealthOfTweets #SmithTweets
The gist of mercantilism is:
- If your imports and exports are equal, that's fair. But,
- If you export more than you import, you bring in silver. That's good! And,
- If you import more than you export, you pay out silver. That's bad.
(IV.iii.) #WealthOfTweets #SmithTweets
Read 20 tweets
Good morning #AdamSmith fans! Today we're talkin' stock lent at interest. It's always considered a form of capital. (I.iv.1) #WealthOfTweets #SmithTweets
Stock lent at interest can be used for consumption or the borrower may use it as capital. If it's used as capital, the borrower can use the profits on their stock to repay the loan and pay back interest—this, says Smith, is more common. (II.iv.1–2) #WealthOfTweets #SmithTweets
Unless the borrower is a country gentleman. No one expects much of those guys. #Ouch (II.iv.3)
dailymotion.com/video/x2hwqln
#WealthOfTweets #SmithTweets
Read 23 tweets
The second half of #WealthOfNations Book 2, Chapter 2 is all about banks. Once you invent money, you have to have somewhere to put it, I suppose. #WealthOfTweets #SmithTweets
Banks. You give 'em paper money for the very first time and crazy things can happen! Like what, you ask? Oh, we're so glad you asked. (II.ii.29) #WealthOfTweets #SmithTweets
Or maybe...not so crazy? A lot of what Smith’s explaining here seems super obvious to us now—you can charge interest on paper money! Fractional reserve banking is a thing! Just like paper money, huge mental adjustments for the 18thC. (II.ii.29–30) #WealthOfTweets #SmithTweets
Read 30 tweets
So, Bhavdip Sanghavi (@bhavdip143), profiteer of the pump-and-dump or stock picking guru? Read on to find out… #tldr #hesaguru
PREAMBLE: I follow a few traders and investors, the first being Assad Tannous (@AsennaWealth). His posting of trading setups & willingness to explain his process was intriguing. As a former accountant, I can do fundamental analyses all day long to pick the investments I like.
What I lacked was a way to get the timing right, meaning potential 30-50% returns instead came in at 10-20%. A technical trader sharing his insight and expertise, and watching the banter between him and other traders, was an opportunity to learn and improve for free. #thanksassad
Read 37 tweets
Wenn es in den Krankenhäusern noch 14 Tage so weiter geht wie in den vergangenen 14 Tage, wäre das Gesundheitssystem spätestens dann wohl endgültig überlastet. Ich hab mal Excel angeworfen und gerechnet #Thread
Kurz zur Methode: Ich habe mir angesehen, wie sehr der 7-Tage-Mittelwert für Normal- und Intensivbetten in den vergangenen 14 Tagen durchschnittlich gestiegen ist. Diese durchschnittliche Steigerung habe ich dann für die kommenden 14 Tage angenommen.
Für Normalbetten war diese durchschnittliche Steigerung in den vergangenen 14 Tagen erstaunlich konstant bei ca 7 Prozent. Klingt wenig, ist es aber nicht. Vor 14 Tagen waren es 992 PatientInnen, aktuell sind wir bei 2290. In 14 weitere Tagen in diesem Tempo wären es 5885.
Read 15 tweets

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