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Fred Wu, MD @FredWuMD
, 5 tweets, 3 min read Read on Twitter
Anyone remember the young man pictured here with Princess Di? On Aug 13, 1985, at 3 years old, Jamie Gavin of Dublin made headlines internationally as the youngest person at the time to undergo heart-lung transplant. The surgery was performed by Sir Magdi Yacoub. #CHD #DonateLife
Jamie was born with hypoplastic left heart syndrome (#HLHS). Surgical options then were few. Bill Norwood had only just published his initial series on HLHS palliation; most centers remained wary. In 1984, another baby with HLHS, Baby Fae, received a baboon heart transplant.
Just 5 months before Jamie's operation, Yacoub's team had performed a heart-lung transplant on 5yo Brooke Matthews of Australia, who was at the time the youngest heart-lung recipient. Her story generated drama when her father held up a hamburger stand to help pay for her surgery!
On August 9, 3-year-old Tina Bran of Southampton fell 50 feet from her apartment window. After she died on August 12, her heart and lungs were retrieved by Yacoub's team and transported to London for the surgery. Jamie did well and was extubated just a day later.
Jamie returned to a normal life in Dublin. On Dec. 18, 1985, he was presented a Children of Courage Award by Princess Diana. Sadly, in 1992, at the age of 11, he died of lymphoma. He was believed to be the world's longest-surviving heart-lung transplant recipient at the time.
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On the night of January 6, 1968, @StanfordMed surgeon Norman Shumway transplanted the heart of 43-year-old Virginia White into the chest of 54-year-old Mike Kasperak. It was the first adult heart transplant to be performed in the United States. #medhistory #DonateLife Dr. Norman ShumwayMike Kasperak and wifeVirginia White
By 1967, Shumway had already spent over a decade researching heart transplantation. In 1959, he and Richard Lower had performed the world's first successful heart transplant in a dog. Thus it was widely expected that he would be the first to perform a human heart transplant.
On Nov. 20, 1967, Shumway's team announced they were ready to attempt heart transplant in a human. However, just weeks later, on Dec. 3, Christiaan Barnard took the world, and Shumway, by surprise when he reported the world's first human heart transplant.
Read 11 tweets
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It's remarkable how quickly heart transplantation took off after Barnard reported his first on December 3, 1967. By August 15, 1969, over a period of less than 2 years, there had been 144 heart transplants performed worldwide (excluding xenotransplants) in 20 countries!
Just for fun, let's see if you guys can guess the order in which countries performed their first respective heart transplants... I'll start with Christiaan Barnard's first transplant in South Africa and go through them in chronological order. I think you might be surprised!
#1.
Date: December 3, 1967
Location: Cape Town, South Africa
Surgeon: Christiaan Barnard
Read 22 tweets
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To date, smallpox is the only major human disease that has been eradicated. September 11 happens to mark 40 years since Janet Parker became the last person ever to die from smallpox, and if you're interested, I thought I'd briefly share the story of this tragic milestone.
Smallpox is a viral infection that has been around for millennia. It was characterized by a fever followed by an eruption of skin lesions that ranged from very mild to overwhelming and lethal. Ramses V, who died in 1156 BCE, is believed to be one of the earliest known cases.
Edward Jenner, an English physician, is credited with the discovery that inoculation with cowpox can protect against the closely related but far deadlier smallpox, and for over a century, this remained the basis for vaccination against smallpox.
Read 16 tweets

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I remember World Aids Day, December 1st, 2010, because I stenciled red ribbons in the snow around #Dublin. #WAD2018 - Beautiful photos taken by @niallcarsonpa - Niall Carson/PA
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#Khashoggi Case Thread: I am going to ‘pin’ this post to use it as an ‘Info Thread’ on the #Khashoggi Case. I am in #Turkey. I’ve been following the case closely and with access to sources & experts here. This is a very ‘sensitive’ criminal case due to ‘Diplomatic Booby Traps’!!!
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Here's the story of how my trauma put a literal hole in my abdomen.

I'm typing as I go; please forgive typos and/or wonky syntax. And try to forgive me if halfway through it I delete and/or disappear. This story, this experience are still pretty raw.
Also, let me go ahead & disclaim:

I am no one. I am an authority on nothing.

I don't have a license to practice anything but driving.

Please never construe anything I ever say as medical, legal, or other advice.

I'm telling a story.

I wouldn't listen to me if I were you.
Let's start with #ACEs.

Y'all familiar w/the Adverse Childhood Experiences (ACE) Study? Published in 1998 & the basis for hundreds more pubs, which point to childhood trauma's impact across lifespan: the higher your "dose" of childhood trauma, the worse later outcomes tend to be
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Years ago, my husband and I had big plans to plant a church. After preparation and seminary, it was almost time to go. We were asked by the committee what our "greatest vision" would be after twenty five years of church planting. /1
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Cú Chulainn is believed to be an incarnation of the god #Lugh, who is also his father! His mother is the mortal Deichtine, sister of Conchobar mac Nessa, the King of #Ulster who ruled from #NavanFort near #Armagh. #CúChulainn #Irishmyths #Irishlegends #FolkloreThursday
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Are you one of those people who's looked back on 2017 and convinced yourself that you haven't achieved anything? Worried about catching up with your mates who seem to have done much better?

Let me tell you a story about #time.

A thread 👇
A long #time ago, back when I was about twelve or thirteen years old, my parents travelled to Uyo.

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*photo credit: waiter foodies.
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