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Antonio Regalado
@antonioregalado
, 4 tweets, 3 min read Read on Twitter
There are several CRISPR documentaries in production. The first to hit the screen is "Human Nature" by Adam Bolt and produced by @DanRather . It's going to premier this Sunday, Mar. 10th @SXSW .

The trailer is just out. Watch:
wondercollaborative.org/human-nature-d…
(1/4)
(2/4) Documentary features commentary by R. Alta Charo, George Daley, Matthew Porteus, @UrnovFyodor, @ethanjweiss + @PalmerWeiss + Ruthie, Francisco Mojica, @hsu_steve and Vlad Putin (@KremlinRussia_E)! has archive footage including of Aldous Huxley . Its pretty comprehensive
(3/4) I know most of the people in this film. It's a reminder to me of the potential fragility of the CRISPR enterprise. Nobody here but us chickens.
(4/4) Here is the SXSW listing schedule.sxsw.com/2019/films/200…

Here is a discussion with the director: sxsw.com/film/2019/adam…
/END
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More from @antonioregalado see all

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Antonio Regalado
@antonioregalado
Going to be tracking all incredible genetics news published today. (THREAD) 1/

First, extinct mammoth burgers are here. “Mammoths are the first documented animal to go extinct due to humans hunting and eating them, so we know they are delicious." synbiobeta.com/synthetic-biol…
2/ CRISPR can eliminate lefties
3/ WHOPPER made of vegetable matter.
nytimes.com/2019/04/01/tec…
amazing story, weak April Fool's angle: nypost.com/2019/04/01/bur…
Read 15 tweets
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Antonio Regalado
@antonioregalado
On April 24th I will be at @Columbia University's inaugural Precision Medicine & Society conference, talking about how the media talks about precision medicine. Killer speaker list! events.columbia.edu/cal/event/show…
Here is the flyer in case anyone wants to attend.
preliminary talk title!

Precision gone mad: A reporter’s adventures with polygenic I.Q. scores, pay-to-play gene therapy, and CRISPR babies.
Read 3 tweets
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Antonio Regalado
@antonioregalado
We wrote about what we think is only the second gene therapy ever tried for Alzheimer's disease, and the only such trial currently open. (1/3)

technologyreview.com/s/613001/docto…
(2/3) far as we can tell, the first (and so far only) gene therapy trial in alzheimer delivered Nerve Growth Factor to the front of the brain in 49 patients. did not see any benefit. Report was in JAMA Neurology in 2018 jamanetwork.com/journals/jaman…
(3/7) There are several approved gene therapies for rare disease and for cancer. But none for common disease. Because what gene would you target? Not really clear as theses diseases not "monogenic"
Read 7 tweets

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JMHendersonSr❌
@JMHendersonSr
@EricHolder has asked an important question:

#When was #America #ever #great?

I realize that there is a nearly unavoidable tendency to snort and spew one's coffee when they hear or read his question for the first time. But, honestly, isn't it worth the exercise to answer it?
So, @EricHolder, I'm going to do just that, and I'm going to ask my ragtag bag of followers and detractors to contribute as well.

I'm going to offer my evidence of moments of American greatness. And I'm going to ask those that read this thread to do the same.
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There's more!

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Eugene
@e_earns
Going to read “The Right Side of History”. This will be some mixture of enlightening, been there done that, and hate-read dunkathon. Let’s see.

No idea what Shapiro’s background is outside trolling libs, but I maybe he’s sort of Straussian? The ‘Jerusalem plus Athens’ thing.
So the thesis is ‘things have never been better, but we’re fucking it up now.’ Pinker + angst.
‘We’ in the book is Americans, natch.
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Kurt Wagner
@KurtWagner8
The Instagram co-founders are doing a joint interview at #SXSW — pretty sure it's their first public interview together since leaving FB abruptly last September
You can watch it here online if, like me, you aren't in Austin

sxsw.com/live/
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Losing autonomy was “an unavoidable thing if you’re successful,” he said
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💡Jim Keat
@IdeasDoneDaily
#sxsw session notes: Creativity in the Age of Invention with Nick Law.

[thread]
Technology has always been essiantial in creativity.
New technology uses the grammar of the technology that came before. (Early film looked like theatre.)
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Dave Weigel
@daveweigel
First question to @amyklobuchar from @karaswisher: What was her reaction to the NYT story? #SXSW
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Gaetan Burgio
@GaetanBurgio
Finally the comments to Mitalipov’s group paper on #CRISPR in human embryos are out in @nature as well as the rebuttal from Ma et al. as brief communications arising #paywall. Let’s have a look more in details -> Thread
One of the major finding of the Ma et al. paper was the discovery of high frequency of inter-homologous repair mechanisms aka loss of heterozygocity LOH -> 1 allele is used as a template for
#CRISPR-HDR -> WT alleles are in fact alleles from the maternal alleles only.
We have been debating a lot on this in the last year or so. The first important comment from @Fatwa_Adikusuma et al is Ma et al. missed deleted alleles. In the paper they edited 6 loci in zygotes and EScells and checked for large deletions nature.com/articles/s4158…
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