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I'll read the full article tomorrow, but just reading the abstract reads like a parody of every TPA trial ever. A few notes /thread/
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
Background paraphrased: "The 4.5 hour time window is too short. We've got a new idea for how to lengthen it!"
Methods:
9 hours seemed like a pretty good cutoff.
A bunch of people were asleep though before they had their strokes. After careful consideration, we figured the only scientific way to guess when a stroke happened while sleep was just go halvies on the time they went to bed.
9 hours seemed like a pretty good cutoff.
A bunch of people were asleep though before they had their strokes. After careful consideration, we figured the only scientific way to guess when a stroke happened while sleep was just go halvies on the time they went to bed.
Results:
Man! The trial was pretty great, but then some other dudes published another *clearly groundbreaking* trial, so we were definitely forced by ethics to quit early!
So many results though!
Man! The trial was pretty great, but then some other dudes published another *clearly groundbreaking* trial, so we were definitely forced by ethics to quit early!
So many results though!
First, it was super duper awesome that the tpa group had better 90 day modified rankin scales. The confidence interval started at 1.01, so obviously that other trial would have made it super unethical to continue our slam-dunk findings.
The secondary ordinal analysis didn't seem to pan out, but, like they say, "secondary is secondary."
What? You heard the ordinal analysis was super duper important after IST-3 came out? Well, sure for that study. Definitely not for ours. Totes different.
What? You heard the ordinal analysis was super duper important after IST-3 came out? Well, sure for that study. Definitely not for ours. Totes different.
Conclusion:
I know the prior guidelines on TPA really stress about how important time is, but let's not all forget that time is just a social construct.
I know the prior guidelines on TPA really stress about how important time is, but let's not all forget that time is just a social construct.
Disclosures:
Of course we got paid.
Dr. Parsons reports receiving consulting fees from Apollo Medical Imaging Technology, Boehringer Ingelheim, Canon Medical Systems, and Siemens; Dr. Wong, receiving grant support, paid to Royal Brisbane and Women’s Hospital, from Boehringer
Of course we got paid.
Dr. Parsons reports receiving consulting fees from Apollo Medical Imaging Technology, Boehringer Ingelheim, Canon Medical Systems, and Siemens; Dr. Wong, receiving grant support, paid to Royal Brisbane and Women’s Hospital, from Boehringer
Ingelheim; Dr. Sabet, receiving travel support from Boehringer Ingelheim; Dr. Christensen, holding stock in Ischemaview; Dr. Mitchell, receiving lecture fees from Medtronic USA and Stryker; Dr. Thijs, receiving advisory board fees from Amgen and Bristol-Myers Squibb,
advisory board fees and lecture fees from Bayer and Pfizer, advisory board fees, lecture fees, and travel support from Boehringer Ingelheim, and advisory board fees and travel support from Medtronic; Dr. Meretoja, receiving advisory board fees, lecture fees, and travel
support from Boehringer Ingelheim and Stryker; Dr. Davis, receiving advisory board fees from AstraZeneca and Boehringer Ingelheim; and Dr. Donnan, receiving advisory board fees from AstraZeneca Australia, Bayer, Boehringer Ingelheim, Merck, Pfizer, and Servier. No
other potential conflict of interest relevant to this article was reported.
/fin/
