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"Doctors have for the first time tested a powerful gene-editing technique in people with cancer" -- NYTIMES

Fact check: CRISPR employed in treating cancer many times in China already.

Risk of US-centric view = miss the action.

nytimes.com/2019/11/06/hea…
Here's a WSJ story documenting pretty convincingly previous use of CRISPR in cancer treatment. wsj.com/articles/china…
If anyone has it, I would like to see the PR from the University of Pennsylvania on their CRISPR test, because it might be the source of the error.
h/t to @jess_devonport for pointing me to a version of the press release. It's kind of muddy but does say "first-in-us" in headline.
eurekalert.org/pub_releases/2…
@jess_devonport A tweeter notes that the word "in" ("in people") also imperfect, since in the cancer application CRISPR is added to immune cells while they are outside the body.
@jess_devonport Story was updated. Wording slightly ambiguous. No correction appended. That's life publishing on the Web.
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Antonio Regalado
@antonioregalado
So the first (of many) books about CRISPR babies is out. "The CRISPR Generation" by @kiranmusunuru , a gene editor at Penn Medicine.

First hand account of being let in on He Jiankui's big secret and what he learned.

amazon.com/Crispr-Generat…
Musunuru is first with a CRISPR babies book. He did it by self-publishing with @BookBaby . Interesting model!

There are several other CRISPR books underway, we reported.

technologyreview.com/f/613908/crisp…
You can hear Musunuru talk about his experience on the @laurahercher podcast The Beagle Has Landed (interview from a while back, but covers material also in book. )
beaglelanded.com/podcasts/kiran…
Read 4 tweets
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Antonio Regalado
@antonioregalado
Gattaca embryo test company corrects Nature Scientific Reports paper on predicting traits from DNA which did not disclose financial interests of the founders. (thread)

nature.com/articles/s4159…
2/ May be some other papers without COI (conflict of interest) statements as well. We will see if authors correct
3/While COI discloses the *roles* of the authors in the company, does not disclose any actual financial interest/COI in the specific technology (genetic models) described in the paper.

Like, who owns it -- Michigan State? The company? -- and is it being used commercially.
Read 5 tweets
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Antonio Regalado
@antonioregalado
The dawn of gene-editing to cure inherited disease.

version 1 -- breaking sh*t

ir.crisprtx.com/news-releases/…
The diseases treated, sickle cell, beta-thalassemia, both caused wrongly shaped hemoglobin. that is what carries oxygen in the blood. painful diseases.
but some people with these diseases don't suffer much, because their bodies still produce fetal hemoglobin (whereas, in the rest of us, it's off).

One of many cases in which "strange" cases provide a map to treatment.
Read 8 tweets

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IndoPacific_SCS_Info
@IndoPac_Info
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Dr. Dena Grayson
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😱HOLY CRAP. A scientist in China claims to have genetically edited HEALTHY babies using #CRISPR. He Jiankui says he altered a gene in HEALTHY embryos before implanting them in the mother’s womb, with the goal of making babies resistant to HIV infection.
nytimes.com/2018/11/26/hea…
#CRISPR is a powerful gene editing tool that targets a gene to be "edited" and have its sequence changed. For several years, scientists have feared that CRISPR might be used to create "designer babies," in a new form of eugenics.😱

#crisprbabies
I can think of MULTIPLE genes that could be genetically altered to create "Super Humans" who have vastly increased strength and endurance. Forget performance enhancing drugs: if this report is true (and I have every reason to think that it is), then we've entered a whole new era.
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