Thread by @ryanfiredragon

💊Possible TREATMENT for COVID-19 with Chloroquine Phosphate

📚I've put together all this information so we know a bit more about this drug. Like possible dosage, side-effects and why it might work.

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#coronavirus #2019nCoV #COVID19 #SARSCoV2 #chloroquine

Hospital Physicians work out treatment guidelines for coronavirus

> Chloroquine 500mg orally per day for 7 to 10 days if patients are old or have underlying conditions with serious symptoms

South Korea, 13th February 2020
koreabiomed.com/news/articleVi…

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Patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups.

China, 18th February 2020
clinicaltrialsarena.com/news/coronavir…

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Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

China, 19th February 2020
jstage.jst.go.jp/article/bst/ad…

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Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia

> 500mg twice per day for 10 days for mild, moderate and severe cases

China, 20th February 2020
ncbi.nlm.nih.gov/pubmed/3207536…

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WEEKLY administration of 500 mg of chloroquine diphosphate can be administered for at least 7 months without undesirable side-effects

USA, 1st Jul 1949
ajtmh.org/content/journa…

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"However, 500 mg [of chloroquine diphosphate] TWICE a DAY is definitely a serious dose"

France, 2nd March 2020
sciencesetavenir.fr/sante/la-chlor…

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Side effects of chloroquine include:

* Gastrointestinal disturbances
* Headaches
* Skin reactions (rashes, pruritus)
* Hypotension
* Convulsions
* Extrapyramidal symptoms
* Visual disturbances
* Depigmentation and loss of hair

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"Chloroquine has been found to cause deposits in the corneal epithelium and to cause retinopathy, and its retinal toxicity is a serious adverse effect"

Poland, June 2017
researchgate.net/publication/31…

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Chloroquine Seizures

"there is a narrow margin between a therapeutic and toxic dose [of chloroquine] and its use should be accompanied by the awareness of possible serious side effects on the central nervous system."

JAMA, 1968
jamanetwork.com/journals/jama/…

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After intake of 1000mg to 2400mg of chloroquine between 2 to 7 days has been reported to appear psychosis followed by schizophrenia, depression and mania.

Duration of behavioral changes ranged from 2 days to 8 weeks.

India, 1995
indianpediatrics.net/mar1995/351.pdf

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Why chloroquine may work? because...

Chloroquine Is a Zinc Ionophore

journals.plos.org/plosone/articl…

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And...

Zinc ion (Zn2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

journals.plos.org/plospathogens/…

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The Zinc theory is better explained in the following video


That's all! Stay safe🙏

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