It is an unwritten law of biology that human males are much more fragile and lack the stamina and resilience in the face of biological challenges such as cancer and infections. 
Notwithstanding their greater muscle mass and physical strength, males are the XY heterogametic genetically weaker sex
The cost that XX females pay for their immunological vigor is a much higher preponderance towards developing autoimmunity.
Women are over represented in almost all autoimmune conditions known to medicine. In lupus, it’s about 7 females to every 1 male identified.
An unforeseen benefit of women’s immunological vigor is their superior ability to respond to immunizations over men. This imbues women with more power to defend themselves against the ensuing microbial attack
Put behaviour aside. There is no argument here. Females simply have stronger and thus superior humoral and innate immune responses.
Studying the differences in immune response between the sexes will show us how we can help males meet any new microbial challenge with the requisite vigour that females come by naturally
