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Krutika Kuppalli, MD FIDSA Profile picture
@KrutikaKuppalli
Jul 30, 2021 • 7 tweets • 5 min read • Read on X
Scrolly
Here is some of the @CDC data that was looked at and published by @washingtonpost to make the recommendations to re-implement #masks earlier this week

Note that the #DeltaVariant is MORE transmissible than
- MERS & SARS
- Ebola
- Seasonal Flu and the Flu of 1918
- Smallpox
1/
#DeltaVariant associated with lower Ct value in breakthrough cases, longer duration of Ct < 30, and higher risk of re-infecton
2/
Breakthrough cases of #DeltaVariant have ~ 10 fold increase in viral load compared to alpha or other lineages
3/
#DeltaVariant may cause more severe disease based on information from #Canada #Singapore and #Scotland
4/
5/
6/
- #DeltaVariant has increased transmissibility and may cause more severe disease
- Individuals infected with the #DeltaVariant may have higher viral load and shed longer compared to original strains

In conclusion
#GetVaccinatedNow
#MaskUp
#AvoidCrowds

• • •

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More from @KrutikaKuppalli

Krutika Kuppalli, MD FIDSA Profile picture
Jan 1
🆕 In @nejm.org "Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection"

Highlights of the article in a 🧵 👇

nejm.org/doi/full/10.10…
(1/) Patient Profile: A 13-year-old girl in Canada with history of asthma was infected with H5N1 avian influenza, a strain commonly associated with wild poultry (D1.1). The source of infection remains unknown.
(2/) Initial Symptoms: The patient initially presented with 2 days of conjunctivitis and 1 day of fever, suggesting early localized infection. They were discharged home with no treatment
Read 9 tweets
Krutika Kuppalli, MD FIDSA Profile picture
Dec 31, 2024
1/ 🦠 🆕 @NEJM article dives into the evolving threat of highly pathogenic avian influenza (HPAI) #H5N1
in humans.

Check out the article here. Full🧵👇
nejm.org/doi/full/10.10…
2/ Since its emergence in 1996, #H5N1 has primarily impacted birds. However, sporadic human cases have occurred, typically involving close contact with infected birds. So, what's changed?
3/ The article highlights recent human cases of #H5N1 , including severe infections, raising concerns about the virus's ability to adapt to humans. These cases underline the need for increased vigilance.
Read 9 tweets
Krutika Kuppalli, MD FIDSA Profile picture
Jul 6, 2022
✨@WHO published its first situation report for the multi-country #Monkeypox outbreak with data till 4 July 2022 there has been

👉6027 cases and 3 deaths in 59 countries in 5 WHO regions
👉2614 new cases (77% ⬆️) & 2 new deaths since last DON

Full🧵👇

who.int/publications/m…
✨Demographics
Sex is available for 73% (4406/6027) of cases
👉Of these, 99.5% (4385/4406) are males (median age 37 yrs)
👉Males 18-44 years of age account for 79% of cases
👉0.1% (6/5584) of cases with age data are aged 0-17 years of age.
✨Demographics
Among cases with reported sexual orientation
👉60% (1214/2025) identified as gay, bisexual and other men who have sex with men
👉41% (335/827) of cases with known #HIV status were positive for #HIV
Read 12 tweets
Krutika Kuppalli, MD FIDSA Profile picture
May 16, 2022
✨Update from @UKHSA on #monkeypox cases

- 4 additional cases have been detected (3 in #London and 1 linked case in NE #England)
- These cases have NO connection to those announced on 14 May and the imported case from 7 May

Full details and more info👇
gov.uk/government/new…
- The four new cases all appear to have been infected in #London and are gay, bisexual, or MSM
- Common contacts have been identified for 2/4 cases
-No link to travel to a country where #monkeypox is endemic
-All have West African clade of virus
-Further investigation is ongoing
- #monkeypox is spread by close contact
- Typical symptoms are fever, headache, muscle aches, backache, swollen lymph nodes
-Rash can develop and spread to other parts of the body including the genitals - it may look like #syphilis #herpes #chickenpox
Read 4 tweets
Krutika Kuppalli, MD FIDSA Profile picture
Jan 31, 2022
New data out today from #Denmark demonstrating that #Omicron #BA2 is more transmissible than #BA1 and has immune evasive properties reducing protective effect of #vaccination

Full 🧵👇
1/ medrxiv.org/content/10.110…
- Of 8,541 primary household cases with #Omicron, 2,122 were #BA2
- There were 5,702 secondary infections among 17,945 potential secondary cases
- In households with #Omicron, secondary attack rate was
29% - #BA1
39% - #BA2
2/ Image
- compared to #BA1, #BA2 associated with ⬆️ susceptibility of infection in
#unvaccinated (OR 2.19)
fully #vaccinated (OR 2.45)
#boosted (OR 2.99)
- ⬆️ transmissibility from #unvaccinated cases in #BA2 houses compared to #BA1 (OR 2.62) (Not seen in vaxd or boosted)
3/ Image
Read 4 tweets
Krutika Kuppalli, MD FIDSA Profile picture
Jan 10, 2022
Latest @WHO #TechnicalBrief on #Omicron
Overall risk remains very high & threat depends on

1⃣Transmissibility of #variant
2⃣How protective vaccines & prior infection are
3⃣Virulence of variant
4⃣Understanding of dynamics & uptake PHSM

Full 🧵👇 (1/)
who.int/publications/m…
Epidemiology (1)
-#Omicron has large growth advantage over #Delta - grows significantly more than Delta in countries with community transmission
- Evidence that immune evasion contributes to rapid spread
-Wk 52, global weekly #COVID19 incidence ⬆️ 71% compared to prior wk
(2/)
Epidemiology (2)
-Study from HK found #Omicron infects human bronchus tissue faster and better than #Delta
-#UK study found Omicron outcompetes Delta in experiments using cells derived from human nose, but not seen in lung derived cells
-Growth advantage in upper resp tract
(3/)
Read 17 tweets

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