I strongly disagree. From a public health point-of-sale view the primary purpose of a #vaccine is to prevent infection and transmission. Clinically, it may be great to block disease, too. Goes to famed Salk vs Sabin debate on polio vaccines.
There are longstanding debates about use of the Salk (IPV) vs Sabin (oral) polio vaccine, for reasons explained well here by @profvrr :
virology.ws/2015/09/10/why…
But back in the 1960s Salk & Sabin debated which of their vaccines better blocked fecal transmission.
MORE
With improved sanitation & clean drinking water polio spread is greatly reduced. But could both viruses cut not just disease in individuals, but also environmental contamination via feces? pubmed.ncbi.nlm.nih.gov/6262150/
MORE
"Oral poliovirus vaccine (OPV), because it is believed to mimic natural (wild) poliovirus infection and to induce serum and mucosal immunity, is considered ideal to interrupt virus transmission in countries with poor sanitation and endemic polio." pubmed.ncbi.nlm.nih.gov/11763328/
MORE
Here's Jonas Salk's take:
"Data are presented to illustrate the degree to which the respective risks occur in developed & developing countries. The ultimate elimination of risk by eradication of wild and vaccine virus frm the population is discussed." pubmed.ncbi.nlm.nih.gov/230106/
MORE
Pre-vaccines, models show 99% of transmission of polio was fecal, frm asymptomatic individuals. journals.plos.org/plosbiology/ar…
And oral vaccines interrupted that: "Trivalent vaccine (OPV) successfully interrupts poliovirus
transmission by producing both serologic and intestinal - "
MORE
" -- immunity. In industrialized countries, 3 doses of OPV result in high rates of seroconversion. Because
excretion of wild poliovirus is prevented... in immunized persons, transmission dies out in highly immunized vaccinated populations"
watermark.silverchair.com/175-Supplement…
I did not refer to "sterilizing immunity" -- rather, lowered risk of fecal transmn, cutting community spread of virus.
A clear case of sterilizing immunity is the rinderpest vax for cattle, which stops spread completely. meta.org/papers/long-te…
Rinderpest was eradicated in 2011.

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More from @Laurie_Garrett

4 Jan
Gulp.
"The United States is headed for civil war & it cannot bear to face it. The political problems are both structural & immediate...The American political system has become so overwhelmed by anger that even the most basic tasks of govt are impossible."
theguardian.com/world/2022/jan…
2/ "The Capitol police have seen threats against members of #Congress ^ by 107%. Fred Upton, #Republican rep from Michigan, shared a message he had received: 'I hope you die. I hope everybody in your family dies.' And it’s not just politicians but anyone involved..."
MORE
3/ "...in the running of the electoral system. Death threats have become a std aspect of the work life of election supervisors & school board membs. A third of poll workers said they felt unsafe."
I'd add that Public Health officials are resigning due to death threats.
Read 4 tweets
25 Dec 21
We watched "Don't Look Up" last night -- dumb movie, but convinced me not to hold back inconvenient truths.
So here goes.
#Greenland The Danish Meteorological Institute says huge warming there is linked to #ClimateChange .
How much "warming?"
MORE
2/
- The capital Nuuk hit 55 F this week -- average temp for this time = 22.5 F
- Further north in Qaanaaq temp topped 46 F -- normal is -4.2 F.
70% of Earth's freshwater is frozen, and #Greenland is the 2nd largest block of ice after #Antarctica. If it were to fully melt...
MORE
3/
...world sea levels would rise 23 feet. climate.nasa.gov/faq/30/if-all-…
That would obliterate the homes, schools, workplaces of >10% of the U.S. population. climate.gov/news-features/…
MORE
Read 5 tweets
22 Dec 21
Imperial Coll in London issued a rather grim assessment of #Omicron in the UK.
Key findings:
- "The growth rates estimated for Omicron translate into doubling times of under 2.5 days"
- "reproduction number (R) estimates for
Omicron are above 3"
MORE
imperial.ac.uk/news/232698/mo…
2/
- "We find strong evidence of immune evasion, both from natural infection, where the risk of reinfection
is 5.41-fold higher for #Omicron than for #Delta & from #vaccine-induced protection.
- Prior study of UK healthcare workers
est'ed that #SARSCoV2 infection...
MORE
3/ cont
- ... gave 85% protection against reinfection over 6 months . Against #Omicron protection anti-reinfection drops to only 19%.
- "We find no evidence of Omicron having different severity from #Delta ."
MORE
Read 5 tweets
21 Dec 21
The former head of the Natl Intelligence Council thinks America is falling apart -- civilly, or towards civil war? Civility?
"In a country whose extreme violence...can only be accounted for by the omnipresence of guns, we would be foolhardy to bet on it."
thearticle.com/civil-war-is-c…
At FT @gideonrachman cites the above, adding:
"The mood of near-despair in #America is nurturing the opposite emotion among the #Chinese elite — a growing conviction that their country is outperforming the US and will eventually displace it as the world’s dominant power."
MORE
2/"#XiJinping proclaimed that 'the east is rising & the west is in decline'.
The fact that America has suffered 800,000 deaths as a result of the #Covid19 #pandemic, while #China claims a toll of below 5,000, is cited as evidence of the superiority of the Chinese system."
MORE
Read 4 tweets
21 Dec 21
Happy Solstice. @POTUS #JoeBiden will address the Nation today, regarding #Omicron #COVID19 & the Holidays.
MORE
2/ In his Winter Solstice speech @POTUS will tackle hospital #Omicron crises by:
•Mobilizing 1,000 troops to deploy to #COVID19 -burdened hospitals
•Deploying Federal medical personnel available to states immediately
•Activating FEMA response teams to help States
MORE
3/ #Biden #Solstice2021 speech cont.
•Deploying 100s of ambulances & Emergency Medical Teams to transport patients
•Pre-Positioning supplies from the Strategic National Stockpile & deploying ventilators to States.

He'll also be radically ramping up #COVID19 testing.
MORE
Read 5 tweets
21 Dec 21
There is so much to talk about today. As #Omicron spreads across #NYC like a summer wildfire in California, it seems clear #vaccination offers little protection against infection, but plenty against severe disease. Thanks to the great folks @HKUniversity we know --
MORE
2/ (cont) that #Omicron infects & reproduces in cells of the bronchus and upper airways. The individual may feel fine, but have billions of viruses that constantly expel as they breathe & talk -- infecting others. If they are #vaccinated fully, individuals mount immune --
MORE
3/-- responses that block #Omicron from penetrating alveoli deep in the lungs, causing pneumonia. They remain ambulatory, vaguely "off" but able to see friends, go to the store, dine out -- spreading virus all of the while. So the #vaccines are a clinical triumph, but --
MORE
Read 7 tweets

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