We have either rapid re-infection, or rebound #Covid19 after Paxlovid, in my own 🏡 . Vaxxed & boosted. Symptoms & rapid test pos 5/2, 5d of Pax 5/4-5/8, all symptoms gone, neg rapid test x 2 5/8 & 5/9.
5/16 new symptoms & RAT instantly pos (📸). Our #MedTwitter 🏡 is weary.
5/16 new symptoms & RAT instantly pos (📸). Our #MedTwitter 🏡 is weary.
https://twitter.com/apoorva_nyc/status/1526191168169680898
By the way, the right answer is not “So Paxlovid doesn’t work.” It works very well to ⬇️ risk of severe illness, which matters a lot. And right answer is not “so let’s just give 10d.” Right answer is we need data to understand this phenomenon & direct rational antiviral use.
I’m sharing this because:
👉Anecdotes can generate scientific hypotheses that THEN MUST BE STUDIED WITH RIGOR &
👉The public needs to know for #publichealth reasons that, one way or another, we can end up symptomatic & contagious again a wk after apparent #COVID19 recovery.
👉Anecdotes can generate scientific hypotheses that THEN MUST BE STUDIED WITH RIGOR &
👉The public needs to know for #publichealth reasons that, one way or another, we can end up symptomatic & contagious again a wk after apparent #COVID19 recovery.
The best reaction to hearing this whole story is: I’m going to #WearAMask while this all gets sorted out.
P.S. We’re a 2 dr household (including one infectious disease physician), & that’s what we’re doing too. #MedTwitter
/End
P.S. We’re a 2 dr household (including one infectious disease physician), & that’s what we’re doing too. #MedTwitter
/End
Adding a P.S. since I’ve gotten a 🌊 of msgs about this tweet today. I’ve now seen credible anecdotes from drs I know personally of the same “rebound” or prolonged positive rapid tests out to 3 wks occurring in pts w/ #COVID19 who have not received ANY treatment, incl Paxlovid.
This leads me to wonder if there’s a big difference in viral kinetics w/ 1 or more of the #covidvariants. It’s poss the current virus takes much longer to peak or to clear. All of this can/should be formally tested. Anecdotes generate hypotheses; they never ever replace science.
5/19 Update on reinfection or #Paxlovid rebound: Symptoms substantial (sinuses, sore throat, very runny nose, fatigue) & rapid test still riproaring pos, even faster than before, ie, super contagious. (NB. Pos control line is faint but there & got redder shortly). 👎 #MedTwitter
Somehow forgot to mention cough, which sounds like it would be productive but is not. Goes day and night, nonstop, preventing all rest. #MedTwitter
5/21 update for those tuning in to our #COVID19 sanatorium. Rapid test still raging pos. Now d6 since onset of rebound symptoms with pos RAT, d20 since 1st pos RAT. We need a prosp study of ppl w/ delayed viral clearance. May teach us a lot re #longCovid. @VirusesImmunity
Why aren’t we requiring neg RAT to exit #COVID19 isolation? Overdispersion means that a very small % of those infected cause most secondary transmission. Are ppl w/ robust viral replication for wks the culprits? We could find out! If we want to end the #pandemic, we should…🤷🏻♀️
Finally, it’s clear that we need robust sterilizing treatments for #COVID19. Whether we use them to interrupt chains of secondary transmission for #publichealth reasons or potentially to prevent/treat #longCovid (note: HYPOTHESIS ONLY for latter), we need them. #MedTwitter
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