@WHO published its first situation report for the multi-country #Monkeypox outbreak with data till 4 July 2022 there has been

👉6027 cases and 3 deaths in 59 countries in 5 WHO regions
👉2614 new cases (77% ⬆️) & 2 new deaths since last DON

Full🧵👇

who.int/publications/m…
✨Demographics
Sex is available for 73% (4406/6027) of cases
👉Of these, 99.5% (4385/4406) are males (median age 37 yrs)
👉Males 18-44 years of age account for 79% of cases
👉0.1% (6/5584) of cases with age data are aged 0-17 years of age.
✨Demographics
Among cases with reported sexual orientation
👉60% (1214/2025) identified as gay, bisexual and other men who have sex with men
👉41% (335/827) of cases with known #HIV status were positive for #HIV
✨Healthcare worker infections
👉 25 cases reported are health workers
👉Health care-associated infections cannot be ruled out
👉Further investigation is ongoing to determine whether infection in health workers was due to occupational exposure.
✨Clinical Presentation
Many not presenting with classic clinical picture for #MPX (fever, lymphadenopathy, followed by centrifugal rash)
Among cases reporting at least 1 symptom,
👉 81% presented with systemic rash
👉 50% presented with fever
👉 41% presented with genital rash
✨WHO Advice - Surveillance and Lab
👉Patients meeting clinical definition for suspected case should be offered testing
👉If high suspicion for #MPX the identification of alternate pathogen should not preclude testing, as co-infection occurs.
👉Primary diagnostic test is #PCR
✨Surveillance and Lab (continued)
👉Most often suspected & reported route of transmission has been sexual contact
👉All known contacts or persons who think they may have been exposed should monitor symptoms for 21 days and seek testing if signs/symptoms of #MPX appear
✨IPC
👉Appropriate IPC measures are essential to mitigate & control transmission
👉Transmission-based precautions (contact & droplet) be implemented for suspect/confirmed cases in health settings including use of respirators by health workers outlined 👇 who.int/publications/i…
✨Clinical Management
👉Patients should receive symptomatic care
👉Monitor & treat complications-secondary bacterial infection, ocular lesions, dehydration, pneumonia, or sepsis
👉Remain in isolation till lesions have crusted, scabs fallen off & fresh layer of skin has formed
✨Vaccines and Therapeutics
👉@WHO encourages member states using #MPX #vaccines and therapeutics to do so within a framework of collaborative clinical studies using standardized design methods and data collection
✨RCCE and Gatherings
👉Focus efforts to raise awareness, manage risk perceptions, maintain trust, and proactively support people to make informed decisions
Huge thanks to the Alert and Response Coordination team in the Health Emergencies Programme @WHO for putting out this this situation report which can be found at
who.int/publications/m…

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More from @KrutikaKuppalli

May 16
✨Update from @UKHSA on #monkeypox cases

- 4 additional cases have been detected (3 in #London and 1 linked case in NE #England)
- These cases have NO connection to those announced on 14 May and the imported case from 7 May

Full details and more info👇
gov.uk/government/new…
- The four new cases all appear to have been infected in #London and are gay, bisexual, or MSM
- Common contacts have been identified for 2/4 cases
-No link to travel to a country where #monkeypox is endemic
-All have West African clade of virus
-Further investigation is ongoing
- #monkeypox is spread by close contact
- Typical symptoms are fever, headache, muscle aches, backache, swollen lymph nodes
-Rash can develop and spread to other parts of the body including the genitals - it may look like #syphilis #herpes #chickenpox
Read 4 tweets
Jan 31
New data out today from #Denmark demonstrating that #Omicron #BA2 is more transmissible than #BA1 and has immune evasive properties reducing protective effect of #vaccination

Full 🧵👇
1/ medrxiv.org/content/10.110…
- Of 8,541 primary household cases with #Omicron, 2,122 were #BA2
- There were 5,702 secondary infections among 17,945 potential secondary cases
- In households with #Omicron, secondary attack rate was
29% - #BA1
39% - #BA2
2/ Image
- compared to #BA1, #BA2 associated with ⬆️ susceptibility of infection in
#unvaccinated (OR 2.19)
fully #vaccinated (OR 2.45)
#boosted (OR 2.99)
- ⬆️ transmissibility from #unvaccinated cases in #BA2 houses compared to #BA1 (OR 2.62) (Not seen in vaxd or boosted)
3/ Image
Read 4 tweets
Jan 10
Latest @WHO #TechnicalBrief on #Omicron
Overall risk remains very high & threat depends on

1⃣Transmissibility of #variant
2⃣How protective vaccines & prior infection are
3⃣Virulence of variant
4⃣Understanding of dynamics & uptake PHSM

Full 🧵👇 (1/)
who.int/publications/m…
Epidemiology (1)
-#Omicron has large growth advantage over #Delta - grows significantly more than Delta in countries with community transmission
- Evidence that immune evasion contributes to rapid spread
-Wk 52, global weekly #COVID19 incidence ⬆️ 71% compared to prior wk
(2/)
Epidemiology (2)
-Study from HK found #Omicron infects human bronchus tissue faster and better than #Delta
-#UK study found Omicron outcompetes Delta in experiments using cells derived from human nose, but not seen in lung derived cells
-Growth advantage in upper resp tract
(3/)
Read 17 tweets
Jan 1
This narrative is exactly what I was worried about👇

We still don’t know #Omicron causes less severe disease but has become so politicized leaders say it only causes a “sore throat” without thinking of the immediate & long term (post #COVID19 condition #LongCovid) effects
#COVID19 and #Omicron most certainly does not only cause a “sore throat” we are seeing ⬆️⬆️ numbers of ICU admits and hospitalizations.
Yes some may have mild disease (thank you #vaccines) but these people can still transmit and put others (ie immunecompromised) at high risk.
The strain this is putting on healthcare systems and workers is tremendous.

Procedures that are non-emergent like cardiac catheterizations, biopsies, & other important surgeries are being postponed. This may lead to delays in diagnosis of things like cancer & adverse outcomes.
Read 5 tweets
Dec 30, 2021
💯agree with @jabarocas - in the past 24 hours 5 healthcare worker friends in different parts of the #US have been diagnosed with #COVID19.
At this rate as hospitalizations ⬆️ there will be an ⬆️ shortage of HCW's- who will care for patients & what will it look like a🧵
1/
✅The provider: patient ratio ⬆️⬆️⬆️
✅Patients wait longer for things like water, ice, food, & meds as nurses are stretched caring for more patients
✅The lab is stretched thin so bloodwork takes longer to return
✅Radiology is busier so it takes longer for an X-ray
2/
✅Physicians have less time to spend with patients and families because they have more individuals to see
✅There is less time to critically think about patients as HCW's are in triage mode trying to meet patients needs (I understand this is concerning, but is reality)
3/
Read 5 tweets
Jul 30, 2021
Here is a link to the @MMWR with the data from the #Provincetown outbreak which led @CDCgov to change their recommendation on #Masks due to the #DeltaVariant

Here is a🧵highlighting the important points
1/

cdc.gov/mmwr/volumes/7…
-There were 469 cases of #COVID19 in Barnstable, MA in July 2021
- 346 (74%) cases in fully #vaccinated
- #Sequencing in 119/133 (89%) specimens confirmed #DeltaVariant
-274 (79%) with breakthrough infection were symptomatic
-4/5 hospitalized were fully #vaccinated

2/
-Ct value similar in fully vax'd (127) vs. those not (84) (22.7 vs 21.5)
-Most cases in males (85%); median age 40
-Time from vax completion -> infection 86 d (6-178 d)
- Vax as cause for breakthrough
#PfizerBiontech (159,46%)
#Moderna (131,38%)
#Janssen (56,16%)

3/
Read 6 tweets

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