Discover and read the best of Twitter Threads about #dna

Most recents (24)

The following paper is one of the most interesting and thoughtful I've read in quite some time.

The authors offer a new framework for understanding if genetic mutations are harmless (benign) or dangerous (pathogenic).

Spoiler: AlphaFold 2 is involved.…
First, I'd like to cite the authors; .@capra_lab, .@rodendm, and .@computbiolgeek. I'm sure they'll correct me if I butcher anything.

I originally stumbled on the paper after reading a thread about it by .@RyanDhindsa, which I've linked below:

Some Background:

The basis of medical genetics is understanding how #DNA mutations (variants) give rise to disease.

Recall that inherited DNA sequence variants can sometimes alter proteins by changing the identity of an amino acid.

This is called a 'missense mutation'. Image
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Achieving racial equity requires investments in good data. This report lays out 10 key recommendations for #AsianAmerican and #NHPI communities, building on the strong #DataEquity work of @WHOSTP @OMBPress @WHIAANHPI 🧵and link… 10 recommendations to advance data equity in AANHPI communit"Disaggregation Plus": Improved federal standards
First, we need federal investments in data collections on #AsianAmerican and #NHPI communities that can offer insights that can inform the work of various federal agencies #DataEquity #AAPI #WhoWeAre Recommendation #1: Create additional case studies and pilot
Next, we need to raise the federal minimum standard for data collection across all relevant agencies that expands upon the categories used in the 2020 Census and American Community Survey #DataEquity #AAPI #WhoWeAre Recommendation #2: Update the federal minimum standard for d
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Elke keer als je denkt: ‘Nu moeten ze het wel gaan snappen.’ wordt er weer een blik #wappies (trollen) opengetrokken. Amusant ware het niet dat ze alles herkauwen. Daarom een eerste hulp bij nieuwe wappen draad. Heb je in één keer 90 procent van het script behandeld 🧵#draadje
Laten we meteen met de deur in huis vallen… #Sarscov2 bestaat niet want het virus is helemaal niet #geïsoleerd. False! Dat gebeurde al in januari 2020. Stelletje sukkels! Lees dit:…
Dan de #PCR test. Die is “vaak” vals positief.. kijk naar wat er gebeurt als je er cola op giet (wie doet dit nou btw?) Ehm nee! Lees dit……
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Thread on #Magnesium and why it is fundamental for our #health. #micronutrients
..many people debate the various ratios of #macronutrients like #protein, #fat, and #carbohydrates in their diet to find their optimal health. Which is great as we are #bioindividuals but most miss out on #micronutrients like #vitamins and #minerals.
The way our bodies are able to use the #macronutrients is fully dependent on how our #enzymatic pathways are influenced by various #micronutrients. One of the most important amongst is #magnesium.
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These people are going to censor all speech? Will these people determine who the domestic terrorists' are? Image
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Please take your seats for @gordon_sanghera's opening plenary of London Calling 2022. #nanoporeconf
GS: Lord Kelvin believed in meaningful measurement to see the whole picture. With nanopore sequencing you gain more comprehensive insights than ever before. #nanoporeconf
GS: In the 3 years since the last time we were at Old Billingsgate, @nanopore has released 200+ products, increased our single-molecule raw read accuracy from 95% to 99.6% & hugely improved our scalability & output. #nanoporeconf
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Let us take a look at $TWST and some #Synbio.

Twist is the #DNA company. They break themselves into 4 different segments with #Synbio, #NGS, #Biopharma, and #Storage.
The first segment is Synthetic Biology. This is what I call the Mail Order DNA business. Many companies need DNA for developing therapies like cell engineering or gene therapies. Many of these DNA strands can be synthesized for just a few cents per base.
This won't be a huge money maker as they can ship hundreds of thousands of DNA sequences a year for just a few dollars per. It is the back bone of their sales, and its still growing nicely. Its the cash cow that will fund the future developments which can be big winners.
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"Systems Thinking is a must have skill in today’s complex, changing, non-linear world where everything is interconnected as well as interdependent." -- Sahana Chattopadhyay @sahana2802…
Choice Quotes from Bill Gates's New Book ⋆ Brownstone Institute…
#BiologicalVirus, #ComputerVirus, #AbnormalPsychology, #IntellectualError, #BookReview
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As per the study published in two prestigious journals, #science & #cell - Ancient Harappan Genome lacks Ancestry from steppe pastoralist or Iranian farmers. This conclusion is based on an analysis of Ancient #DNA belonging to a..
Women who lived in #harappan civilization site of #Rakhigari in haryana around #2600BC.The prevalence of steppe pastoralist gene is higher among the upper caste than lower caste& that it about is twice as high among the #brahmins as compared to #SC& #ST~Tony Joseph(Early indians)
From the above findings it can be said with 100% surity that so-called upper caste & caste brahmans who call themselves carriers of vedic traditions weren't present in indus valley. So, this rules out any possibility of any cultural exchange b/t both groups. Right?
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A pinch of pinscher, a dash of 'shund... a pint of pittie for good measure, and what kind of #dog do you get?
Ulti-mutt-ly: a distinct individual.

Happy to share our article on dog genomes, behavior, and MUTTS in @ScienceMagazine! @UMassChan @broadinstitute #ScienceResearch 1/n
Even the most mixy of #mutts cannot escape the question: what's in the sauce? For the first time, we unravel the genomes of mutts (1500+ dogs of mixed or mystery heritage) and what they can show us about the inheritance of behavior. 2/n
Research was made possible thanks to the thousands of dogs enrolled in our Darwin’s Ark project ( @darwinsarkfnd

See: dog tax attached #communityscience #citizenscience #CitizenScienceMonth 3/n
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@euphoniYum @spriter99880 1/3. There is a #Power called "#Evolution" and the #Survival of the best "#Fit".
To #Unite many #Different views into 1 and giving up one's OWN desires for that of the GROUP, Homo Sapiens Sapiens developed #DNA-caused "#Group #Thinking", to change from #Many views to #ONE.
@euphoniYum @spriter99880 2/3. >>But these #Genetics are #Predictable and can be #Manipulated by the #Few.
Mass-Psychologists, in #Think #Tanks of the ruling class in the West, Oligarchs, developed "#NLP" or "#Neuro-#Linguistic #Programming", known as "Marketing", Brain Washing and yes... Propaganda.
@euphoniYum @spriter99880 3/3. >>Key is the presence of "#Fear", "#Uncertainty" & "#Chaos".
An article about this Geopolitical tool used by the #Empire from #SouthFront, blocked by Twitter.
The URL is in the top of the page. That will work.
scroll👇1st page
SouthFront👉👈via Archive
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La scoperta della doppia elica: 69 anni fa Watson e Crick (per merito di Rosalind Franklin) svelavano il mistero della struttura del #DNA (già nel 1869 il biochimico svizzero Friedrich Miescher isolò gli acidi nucleici). Un breve thread per ricordare. 1/n 🧵
Uno aveva 23 anni ed era un biologo statunitense, l’altro ne aveva 35 ed era un fisico britannico. I loro nomi sono tra i più famosi nella storia della Scienza: James Watson e Francis Crick. 2/n
Lavoravano insieme da poco meno di due anni (dall’ottobre del 1952) quando, discutendo nel loro studio presso il Cavendish Laboratory (il dipartimento di fisica di Cambridge), il 28 febbraio 1953 si resero conto di avercela fatta. 3/n
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Abrechnungsdaten der Krankenkassen belegen #Sicherheitsdesaster der #GenImpfstoffe

"Während die #CDC inzwischen zugesteht, dass mehr #Impfkomplikationen auftreten als in den Meldesystemen auftauchen (#Underreporting), bleibt das
#PaulEhrlichInstitut hartnäckig bei der Behauptung es werde lückenlos gemeldet. Man gehe stattdessen sogar von einem #Overreporting aus, da viele Menschen zufällig zeitgleich aufgetretene Beschwerden als impf-assoziiert melden würden und allgemein noch eine große Nervosität
ob der neuen technologischen Plattformen der #RNA- und #DNA-Impfungen bestünde. Offizielle Abrechnungszahlen gesetzlicher Krankenkassen beweisen das Gegenteil.

Bereits in der ersten Jahreshälfte 2021 lag die Häufigkeit von Impfkomplikationen laut Abrechnungssystem der
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1️⃣ #رشتو مهم
نزدیک ۹۹ درصد از ژلاتین های کشور خوکی است
( بخشی که از طریق #وزارت_بهداشت وارد می شود نه وزارت جهاد کشاورزی)‼️

ژلاتین در شکلات، بستنی، ماست، خامه، داروها کاربرد دارد.
محصولات مبتنی بر ژله نخورید ...
آخر مشکل رو اول ببینید و ببینانید👇
2️⃣ و اما قضیه چیه ؟
برچسب حلال هم شده مثل رابطه
سیب سلامت و سوسیس و پفک و نوشابه!🙂😏
3️⃣ واردات محصول غیر شرعی‼️
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Man wollte mir gestern die #Kinderimpfung madig machen, weil in ganz bestimmten Fällen doch eine Umschreibung von RNA in DNA möglich sei.

Ja, Klaus-Dieter, man nennt das Enzym Reverse Transkriptase!

Und nein, einfach NEIN! Es kommt nicht im Körper deiner 5 jährigen vor!

Es gibt diese Reverse transkriptase, die RNA in DNA umschreiben kann. Stellt euch vor, die braucht man täglich, um eure ganzen PCR-Proben vorzubereiten. Um rauszufinden, ob in euren Zellen Virus-RNA sitzt. Die PCR braucht nämlich ein Doppelstrangmolekül. Und RNA ist das nicht.
Weil mir euer ganzes YouTube-Halbwissen so unendlich auf den Keks geht, hier eine Einführung in die Durchführung einer Isolation von Virus-RNA.
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@collcurran As @GeorgeWill commented #Parents send children to school for education, not indoctrination.
It is wrong on #facts -there's no 1 gene for race, but there are sets of genes that characterize different groups, races. It's just #DNA it's not political. hannah-jones misunderstood the genome science
It's pernicious in its indoctrination of children. @RTDNEWS "Whiteness is evil" is one central "truth" being indoctrinated into children. White children are forced to stand up, confess "I am white. I am privileged. I am an oppressor." 6 yo asks "Mommy, am I evil? I'm white." #RVA
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#Medium #Mediumship, was reading an old #Tufts@TuftsDaily⁩ article from 2008 interviewing ⁦@jessicaalba⁩ about her film #TheEye, watched the trailer:
you do see how see people died, though, if contacted by the deceased, they share their personality, images of what is relevant, what they think is, which can be difficult; I take #antidepressants, and, am #healing myself from illness, some #trauma, too, and, was seeing more,
earlier in my healing, and believe it is crucial to have a filter/level of #health with, a pretty well-known #medium told me he also got very sick with #pnemonia, I had #mycoplasmapnemonae, in #MeCFS #CFS, had #Lyme #LymeDisease, too, and, the information is for #healing,
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1️⃣ #DNA daki en ufak bir değişiklik bile öngörülemeyen sonuçlara yol açabilir"

CRISPR geliştiricisi Jennifer Doudna

#CRISPR nedir?
Gen değiştirmeyi mümkün kılan yöntemin adı

#bilinç #bilgi

@desi_athena @SedaOzsry @gulltemel Image
2️⃣#CRSPR çalışma yöntemi:#DNA yı belli bir noktadan kesebilen bir tür moleküler makas olarak çalışmakta ve bu makasın#DNA sarmalı üzerinde belirlenen noktaya yönlendiren rehber bir molekül.Bu yöntem sadece bedensel hücrelerin #Genom düzenlemelerinde kullanılabiliyor. Image
3️⃣ Rehber #RNA yani #mRNA

#mRNA (haberci RNA) aşısı, sentetik RNA moleküllerini insan hücrelerine transfer eden yeni bir aşı türüdür.

Peki bu aşı ile yapılmak istenen nedir?
İnsan genetiğinde nasıl bir değişim ve dönüşüm hedefleniyor? Image
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Some people do bad things, but, they don't look bad.
They are others who do good, but, they don't look good.
It's how we are intrinsically made, that shapes our personality, defines our intentions and describes our actions.
Our #DNA is the repository that informs our evolution.
Ask the maker why he made it?
Not from the doer.
We human beings are at the receiving end, always!!
We are what we are!
We all are made according to a certain specification list.
If we try to mutate ourselves forcefully too much, we won't remain what we are.
Be #Adaptative without violating the complex laws of nature.
Read 6 tweets
This is what targeted racial harassment looks like: nitpicking things like “smiled” or “wore clothes like a celebrity, as a celebrity” or “bought cookware.” It is part of the “gold digger” narrative.
This is common in #healthcare#professionalism” where there is hazing & bullying by racist &/or classist made up non-rules lacking standards…yet people are called “breaking the rules.”

It’s exactly how bullies operate: double standards, mislabel/smear, exclude, marginalize.
In the U.K., “BAME” includes the formerly colonized, thus making race constructs or power different from U.S. as latter had race-based chattel slavery.

Thing is, those formerly colonized have many who have internalized self hate & racism.…
Read 76 tweets
Vi saluto con questo post riassuntivo e panoramico di ciò è stato rilevante in ambito biologico/biotecnologico/medico nel 2021 secondo la rivista Science. Mi auguro sia un thread utile e piacevole. Partiamo 🧵
#COVID19 #Omicron #science Image
La scoperta dell'anno: l'intelligenza artificiale che predice la struttura delle proteine. La scorsa estate Science stessa pubblicava i risultati relativi alla capacità di un algoritmo artificiale (RoseTTA fold) nel predire la struttura di proteine e complessi proteici. 2/n
#IA Image
Pillole antivirali contro #COVID: i risultati da #Merck (#Molnupiravir) e #Pfizer (#Paxlovid) sono molto buoni: verranno utilizzate per i pazienti non ospedalizzati con malattia lieve-moderata di recente insorgenza con fattori di rischio per lo sviluppo di malattia grave. 3/n Image
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2021 hat uns ein Thema nie losgelassen: Mythen und #Desinformation rund um das Thema #Impfen. Deshalb hier nochmal gesammelt einige unserer Faktenchecks dazu. Vielleicht hilft es euch ja bei der Diskussion mit Familie und Freund*innen während der Feiertage. Let's go! (1/12)
Können Covid-19-Impfstoffe Frauen #unfruchtbar machen? Das ist unbelegt: Es gibt keinerlei Hinweise darauf, dass die bisher zugelassenen Covid-19-Impfstoffe Frauen unfruchtbar machen könnten. (2/12)…
Wurden die Impfstoffe zu schnell entwickelt und nicht ausreichend getestet? Das stimmt so nicht: Einordnungen wie „zu schnell“ sind subjektiv. Fakt ist, dass sie nach den geltenden Kriterien entwickelt und mit tausenden Freiwilligen geprüft wurden. (3/12)…
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A recent publication by Dennis Lo et al applied long-read sequencing (LRS) in the prenatal screening (#NIPT) setting. It's a rather unorthodox technology/application pairing, and it's got me scratching my head a bit.

Open Acces Link:…
For context, earlier this year, Lo et al published a convolutional neural network ("the HK model") that enabled PacBio LRS devices to read methylation (5mC) across the entire genome with very high fidelity. This is important later.

What's methylation?
PDF of HK Model Paper:…

I'll summarize my main takeaways from the current paper and end with some of my open questions/concerns.
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