1/ Reeeeeally happy to see @ChrisMasterjohn's opinion addressing Lp(a) regarding its relevance in causality of CVD, particularly with regard to genetic influence on baseline levels. @siobhan_huggins did a presentation on this at #LowCarbHouston
@ChrisMasterjohn @siobhan_huggins 2/ As with LDL-P, we feel it's relevant to disentangle three major components that influence Lp(a) levels: (1) genetic baseline, (2) disease-induced influence, and (3) metabolic influence
(1)- has surprisingly little study
(2)- generally assumed
(3)- little to no focus
(1)- has surprisingly little study
(2)- generally assumed
(3)- little to no focus
@ChrisMasterjohn @siobhan_huggins 3/ These three are extremely important to consider individually, particularly the metabolic, as @siobhan_huggins has demonstrated multiple times just how rapidly she can alter her Lp(a) numbers to follow the same Inversion Pattern that impacts LDL-C cholesterolcode.com/tandem-experim…
@ChrisMasterjohn @siobhan_huggins 4/ In other words, there might be a higher relative Lp(a) increase for some that comes with going on a #keto/#lchf diet primarily due to a metabolic influence being powered by fat.
Many (like myself) don't see this rise, seemingly because our baseline genetic influence is lower
Many (like myself) don't see this rise, seemingly because our baseline genetic influence is lower
