Thread by @AngelinaNic6

Concerning the CARONAVIRUS -

Someone got Busy , In The Lab .... If you don t know The virus , How can You Give It A Name , No Cure .... Brilliant timing ! Do you Want The Antidote of This Bug ?

The following information was provided by Timothy Webster

#Coronavirus #US #Patent Number #US7220852B1 Synthesized & Registered/Patented in 2015 [In development since 2003 {This application claims the benefit of U.S. Provisional Patent Application No. 60/465,927 filed Apr. 25, 2003,

which is incorporated herein by reference in its entirety.}]

patents.google.com/patent/US72208…

The US Coronavirus Patent #expired today 01/21/2020, the sameday the first case was announced in the U.S.

This invention was developed for/with &/or by the centers for disease control & prevention (#CDC), an agency of the US #Federal #Government; therefore the US Government has certain rights for the application of this invention.

Disclosed herein is a newly isolated human coronavirus (#SARS-#CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames,

as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.

The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16.

The coronavirus may be used as a vaccine under the guise of treating and/or preventing a disease, such as infectious bronchitis, in a subject.

The variant replicase gene may encode a protein comprising one or more amino acid mutations selected from the list of:

Pro to Leu at position 85 of SEQ ID NO: 6,
Val to Leu at position 393 of SEQ ID NO: 7;
Leu to Ile at position 183 of SEQ ID NO: 8;
Val to Ile at position 209 of SEQ ID NO: 9.

The replicase gene may encode a protein comprising the amino acid mutation Pro to Leu at position 85 of SEQ ID NO: 6.

The replicase gene may encode a protein comprising the amino acid mutations Val to Leu at position 393 of SEQ ID NO: 7; Leu to Ile at position 183 of SEQ ID NO: 8; and Val to Ile at position 209 of SEQ ID NO: 9.

The replicase gene may encodes a protein comprising the amino acid mutations Pro to Leu at position 85 of SEQ ID NO: 6; Val to Leu at position 393 of SEQ ID NO:7; Leu to Ile at position 183 of SEQ ID NO:8; and Val to Ile at position 209 of SEQ ID NO: 9.

The replicase gene may comprise one or more nucleotide substitutions selected from the list of:

C to T at nucleotide position 12137;

G to C at nucleotide position 18114;

T to A at nucleotide position 19047; and

G to A at nucleotide position 20139;

compared to the sequence shown as SEQ ID NO: 1.

The coronavirus may be an infectious bronchitis virus (IBV).

The coronavirus may be IBV M41.

The coronavirus may comprise an S protein at least part of which is from an IBV serotype other than M41.

For example, the S1 subunit or the entire S protein may be from an IBV serotype other than M41.

patents.justia.com/patent/1013070…

Partners and collaborators include AstraZeneca,
Regeneron, Roche/Genentech, ApolloBio Corporation, GeneOne Life Science, The
Bill & Melinda Gates Foundation,

Coalition for Epidemic Preparedness
Innovations (CEPI), Defense Advanced Research Projects Agency, National
Institutes of Health, National Institute of Allergy and Infectious Diseases,
National Cancer Institute, HIV Vaccines Trial Network, Walter Reed Army

Institute of Research, Medical CBRN Defense Consortium (MCDC), The Wistar
Institute, and the University of Penn. $56 million invested last year by the Coalition for Epidemic

Preparedness just last year....damn right there’s gonna be a ‘outbreak’. Someone needs to double their investments soon 🙄

@threadreaderapp unroll please