Discover and read the best of Twitter Threads about #sars

Most recents (24)

Even after the memo released recently about the boundaries & operational limit of #SARS, the criminally minded “cult” are still on rampage carrying out illicit arrest & detention of Nigerians, & this is still happening because some Nigerians urge...
@segalink @PoliceNG_CRU
them on With money inducement(bribe) to inflict physical, psychological torture (not also forgetting the monetary extortion) on fellow citizens.
I’ve been trying to reach my in-law since yesterday, cos we’ve been discussing about a business investment for a while now, - 2
and I wanted to get…
Feedback from him so as to his stand as to if we’re moving ahead with the biz – but he hasn’t been taking his calls; I just assumed that he was busy with business reaching and doing follow ups on his clients who are mostly based in Nigeria, since - 3
Read 34 tweets
1/ Spesso si sente parlare di nano-tecnologia: ossia della possibilità di realizzare macchine molecolari finalizzate a scopi ben specifici come ripulire le arterie dal colesterolo in eccesso. In realtà alcune macchine molecolari esistono già e si chiamano proteine. 👇👇👇
2/ Le proteine sono macchine molecolari che svolgono funzioni chiave per la vita. Sondano l'ambiente (gusto e olfatto), compiono lavoro meccanico (contrazione muscolare, digestione cibo) e formano strutture (capelli, ossa).
3/ Una grande differenza tra una macchina macroscopica ed una nano-macchina è che la prima dobbiamo assemblarla noi mentre la nano-macchina è in grado di assemblarsi da sola in apparente violazione del secondo principio della termodinamica.
Read 34 tweets
Our paper about #SARSCoV2-specific #tcell immunity in cases of #COVID19 and #SARS, and uninfected controls is now out, peer-reviewed and published in @nature! nature.com/articles/s4158…

3 take-home messages:
(1/5)
1) Infection with #SARSCoV2 induces virus-specific T cells

2) Patients recovered from #SARS 17 years ago still possess virus-specific memory T cells displaying cross-reactivity to #SARSCoV2
(2/5)
3) Over 50% of donors with no infection or contact with SARSCoV1/2 harbor expandable T cells cross-reactive to #SARSCoV2 likely induced by contact or infection with other #coronavirus strains
(3/5)
Read 5 tweets
Pls read #SARSCoV2 immunology🧵& subthreads for what media & “experts” are not telling you

Facts
-we have some pre-existing cross-protective immunity
-basing herd immunity only on antibodies omits strong Tcell immunity
-vaccine candidates not effective b/c don’t elicit IgA prodn
2/ Last week, researchers in Sweden and Germany also found strong T-cell responses to #SARSCoV2 which bode well for long-term immunity & found pre-existing cross-protective immunity: findings are consistent with the original US Cell study published in May.
3/ We now have three independent #SARSCoV2 studies, from teams of scientists in three different countries, all concluding the same thing:

#COVID19 Herd Immunity Is Much Closer Than Antibody Tests Suggest”
reason.com/2020/07/01/cov…
Read 13 tweets
Starting in a couple of minutes:
#COVID19: Updates from #Singapore, a weekly seminar on the #coronavirus situation in Singapore

This week's guest is @mpkieny.

Hosted by: @profdalefisher, Dr. David Allen

@WHOGOARN
Registration webpage:
medicine.nus.edu.sg/cet/webinar/
Fall in #COVID19 death rate in past few months, situations in most regions appear to be stabilising

@profdalefisher
Read 25 tweets
Loads of excitement today about use of steroid dexamethasone to treat #COVID19 . Steroid use for #SARS 2003/4 had long lasting side effects & was controversial. I want to caution, not dismiss use for COVID. A few references worth studying now.
MORE
Doses & specific drugs used in steroid treatment of #SARS in 2003/4 compared to dexamethasone use for #COVID19 but let's consider side effects issues. More citations:
europepmc.org/articles/pmc70…
and
wwwnc.cdc.gov/eid/article/9/…
and
sarsreference.com/sarsref/treat.…
and
straitstimes.com/singapore/bone…
Read 3 tweets
Comparing #MAGA Rallies to #BlackLivesMatter protests in terms of #COVID19 risk is the new false equivalency. As a doctor I see unique public health risk with a #TrumpRally, which is why he’s making attendees sign waivers absolving him of liability if they get it. Some facts: 1/8
First, many #MAGA rallies are indoors. There is mounting evidence that aerosols (tiny exhaled droplets) containing #SARS-CoV-2 can linger in the air for 3 hours or more in indoor spaces with poor ventilation, and travel on air currents to others. 2/8 nejm.org/doi/full/10.10…
Second, while mask wearing has been shown to significantly decrease the spread of #COVID19, @realDonaldTrump continues to defy public health recommendations, and it is expected that a majority of attendees will follow his lead. 3/8 reuters.com/article/us-hea…
Read 8 tweets
Our latest preprint from the #COVID19 Dispersed Volunteer Research Network is now live at [biorxiv.org/content/10.110…]!

We use machine learning techniques to map the existing #coronavirus literature & identify research needs for #SARSCoV2 (compared to #MERS- & #SARS-CoV here).

1/N
(This study was led by @AnhvinhDoanvo in collaboration with @Money_qxl, @qramjee, @EvolvingEpitope, @angeldesaimd, & myself. It started off as one of our research hackathon projects in late March, & it's been such a delight to oversee its development over the last 11 weeks!)

2/N
Perhaps unsurprisingly to those familiar with scientific funding mechanisms, we find via PCA & LDA that #COVID19 studies (both preprints & peer-reviewed) have primarily been dominated by clinical, modeling, & field-based – as opposed to laboratory-based – research to date.

3/N
Read 6 tweets
Ahora que estoy ordenando información sobre la pandemia del coronavirus de los últimos meses, vamos a hacer un hilo con algunos de los momentos que han quedado (o deberían) quedar en la memoria colectiva. Así que, toca HILO ... y bien largo. 👇👇👇
1. En diciembre, Li #Wenliang, oftalmólogo chino que trabajaba en el Hospital Central de #Wuhan, detectó siete casos de un virus que se asemejaba al #SARS, el que provocó una epidemia global en 2003. Se sospechaba que los casos provenían del mercado de pescados y mariscos Huanan.
2. El 30 diciembre, Li le envió un mensaje a sus colegas en Wechat, advirtió del brote y recomendó usar ropa protectora. Las capturas de pantalla con sus mensajes llegaron a los supervisores médicos y la policía, que lo acusó de difundir rumores falsos en internet (documento👇).
Read 8 tweets
It's been hard to describe about what living with chronic post #COVID19 fatigue is like.

This fab piece by @claudiatanner where she spoke to @bcdelaney1, Prof Paul Garner of Liverpool Tropical Medicine School & actress Gemma Hepworth who all had it. /1

inews.co.uk/news/health/co…
Also if you have had the symptoms over a long period of time in the way myself, @bcdelaney1, Gemma and Paul describe please if you have not already talk to your GP and as I have done and Prof Tim Spector of @KingsCollegeLon encourages please self-report your symptoms on their/2
#COVID19 tracker app. /3
Read 24 tweets
1-#COVID19 her ne kadar çocuklarda erişkinlere göre daha hafif seyirli olsa da, ekonomik koşullarının dezavantaj yarattığı coğrafyalarda, çocukların bu hastalıktan daha az etkilenmesi için önlemler şart. BMJ Global Health’de yeni yayınlanan makaleyi özetlemeye çalıştım:
2-Bu çocuklarda hayati öneme sahip, oksijen, antibiyotik, kişisel koruyucu ekipmanların sağlanması; rutin aşılama, doğum ve doğum sonrası bakım, emzirme ve daha sonrasında beslenmenin desteklenmesi, HIV ve sıtma için profilaksi ve tedavinin sağlanması kritik.

📸 #UNICEF
3-Tüm bu desteklerin sağlanması ve tedarik de yaşanacak tüm aksaklıkların giderilmesi (ki bunun pandemi ile ilgili alakası yok, her zaman olması gereken insani hakları), yoğun bakım koşullarının iyileştirilmesinden çok daha fazla yaşamı kurtaracağı düşünülüyor.

📸 #UNICEF
Read 8 tweets
1. Background: An ongoing outbreak of coronavirus disease 2019 (#COVID19) has spread around the world. It is debatable whether asymptomatic COVID-19 virus carriers are contagious.
2. We report here a case of the #asymptomatic patient and present clinical characteristics of 455 contacts, which aims to study the infectivity of asymptomatic carriers. (link at the end)
3. Material and methods: 455 contacts who were exposed to the asymptomatic #COVID19 virus carrier became the subjects of our research. They were divided into three groups: 35 patients, 196 family members and 224 hospital staffs.
Read 7 tweets
Imp Thread: public health fallacy to claim popn #SARSCoV2 IgG serology tests capture all pts recovered from #COVID19: grossly UNDERestimates % popn that was asymptomatic & recovered. Key arms of immune response to #SARSCoV2: humoral with antibodies & cell-mediated with T-cells
2/ Current public health method to estimate population immunity to #SARSCoV2 from recovered asymptomatic #COVID19 ppl uses serology tests to detect IgG antibodies: this only captures humoral immunity. Currently no widely available testing kit for T-cell immunity to #SARSCoV2
3/ Pts mount strong T-cell immune responses to #coronaviruses. Published Cell research & studies on recovered #COVID19 pts w/immunodeficiency disorders w/inability to mount B-cell responses to #SARSCoV2 reveal B-cell antibody responses not strictly required to overcome COVID-19
Read 6 tweets
1/5 Was a great pleasure to collaborate with Grigory Efimov's @grigory_efimov lab on the analysis of T-cell repertoires in #COVID-19 patients, identifying public T-cell responses to #SARS-CoV-2 antigens in #COVID-19-exposed donors. Main findings of [medrxiv.org/content/10.110…] are:
2/5 While anti-#SARS-CoV-2 antibody levels can tell convalescent patients from healthy ones, T-cells can distinguish both convalescent patients and donors sampled during #COVID-19 pandemic from control donors sampled pre-pandemic.
3/5 Tetramer-sorting reveal hundreds of TCRs specific to two #SARS-CoV-2 epitopes, A*02:YLQ and A*02:RLQ. These TCRs display conserved motifs shared across patients. Short CDR3s and restricted gene usage suggests that epitope recognition is both germline-encoded and public.
Read 5 tweets
📣 Starting this afternoon at 3:30 pm PST! Science journalist and @NPR science correspondent Richard Harris (@rrichardh) will be joining the latest #CovidTownHall in our series to discuss science reporting during a pandemic with @ucdavis students. You don't want to miss this!
Richard Harris has covered science, medicine and the environment for @NPR since 1986. His award-winning work includes reports in 2010 that revealed the US Government was vastly underestimating the amount of oil spilling from the Macondo blowout in the Gulf of Mexico. #journalism
He also shared a @PeabodyAwards with colleague Rebecca Perl for their 1994 reports about the tobacco industry’s secret documents, which showed that company scientists were well aware of the hazards of smoking. #journalism #reporting #sciencejournalism
Read 51 tweets
Promised to tweet out a few more thoughts from my reporting on #covid19 clustering and dispersion factor k. So here goes:
Quick recap first: Reproduction number R is an average. R = 3 does not mean every person infects three others. It’s more like busses that “come” every 10 minutes and you end up waiting 30 minutes and 3 come along.
In reality some people infect a lot of people and most people infect no-one. That’s particularly pronounced in coronaviruses like SARS. In his 2004 Nature paper @jlloydsmith estimates that in Singapore before control measures 2/3 of people with #SARS did not transmit at all.
Read 15 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets
Mwanasayansi mwenye ubobezi wa kimataifa kwenye maswala ya vitendanishi na vipimo (Diagnostics), Dr. Ally Mahadhy, aliandika haya kwenye ukurasa wake wa facebook, ni vyema wadau humu wakayapata ili kuongeza uelewa @Udadisi
@MariaSTsehai @fatma_karume
#ElimikaWikiendi
Uzi 👇🏽
"Kutakucha tu!

Tukiwa tupo kwenye taharuki juu ya kipimo cha corona (covid-19) hapa nchini, baada kutoa majibu ya positive kwa mbuzi na papai, naomba nitoe maoni yangu kama mdau katika tansia hii ya vitendanishi vya maabara (diagnostics). ..." /1
Nianze kwa kutangaza maslahi yangu binafsi kwenye mada husika. Mimi ni mtafiti kwenye eneo hili la vitendanishi (Medical and clinical diagnostics). Tasnifu (thesis) yangu ya umahiri (MSc in Biotechnolgy) iljikita kwenye kutengeneza njia (method) ya kutambua kwa haraka na wepesi/2
Read 61 tweets
Millions of children worldwide have already been exposed to #SARS-COV-2; hospitalizations and deaths are vanishingly low. Yet, suddenly, just as the media and lockdown governors need a new reason to panic people, New York state@reports three child deaths “related to” #COVID...
“Related” how? Who knows? Some of the kids (and others who were hospitalized but fortunately didn’t die) had an active infection; some had antibodies; some had neither. Did they have other serious medical conditions? Nobody is saying...
Is there a plausible or even implausible mechanism of action here? Your guess is as good as @NYGovCuomo. No matter, this is all the excuse anyone needs to keep camps closed all summer... and maybe even schools in the fall. Wait for it.
Read 3 tweets
The #CCPCoverUp led to a #Pandemic that now threatens the lives of people around the globe. See through the deception, and keep yourself and your family truly informed. (Thread👇)

Let's reject the #CCP.

Sign the petition: ccpvirustruth.com
The #CCPLied about the origin of the outbreak and covered it up, costing the world 6 valuable weeks of preparation.

The #CCPVirus started in central #China, and might have been contained there—but instead, it was allowed to spread, creating a #GlobalPandemic.
Unfortunately, the #CCPVirus is only the tip of the iceberg.

For decades, the #CCP has been actively undermining the economies, #NationalSecurity, and moral fabric of nations around the world.

Sign the petition: ccpvirustruth.com
Read 11 tweets
#Remdesivir begins distribution in the #USA today via #EUA.

I thought would write down some practical #tips based on my #qualitative anecdotal experience after personally treating close to 200 patients with #COVID19.

For quantitative results, wait for the papers¬—thread
“this juice works, doc!” When you hear similar expressions 1-2 days after starting #remdesivir multiple times, you start to wonder. Don't recall a similar proportion of patients smile after feeling so sick 1-2 days earlier with #COVID19. x/n? Wait for the papers.
Like #treatment for any severe infectious disease (meningitis, Gram-negative bacteremia, influenza pneumonia, etc), earlier is always better. #COVID19 is no different. #Remdesivir stops #SARS-CoV2 replication, but won’t heal the lung injury.
Read 13 tweets
La única salida real a la epidemia de #COVID-19 es lograr lo que se conoce como ‘inmunidad de grupo o rebaño’ (herd immunity) contra #SARS-CoV-2, el virus que causa le enfermedad que conocemos como COVID-19

Pero ¿cómo y en cuánto tiempo podríamos lograrlo en Chile?

Abro hilo...
¿Qué es la inmunidad de grupo?

Cuando la mayoría de la población es inmune a una enfermedad infecciosa, esto proporciona protección indirecta, a aquellos que no son inmunes a la enfermedad.
Poee ejemplo, dependiendo de cuán contagiosa sea una infección, generalmente del 70% al 90% de una población necesita inmunidad para lograr la inmunidad del rebaño.
Read 15 tweets
1/ #Ebola RNA was found in the aqueous humor of the eye, and persistence was describe in the CNS, #placenta, and in semen up to 565 days post-acute EVD, highlighting the need to investigate the parameters of EBOV clearance from immune-privileged organs.

ncbi.nlm.nih.gov/pmc/articles/P…
2/ Case series from prior epidemics report an 89%–93% case fatality rate among pregnant women, and perinatal mortality is 100%. No reports have been published of neonates surviving trans-placental #Ebola Virus Disease for longer than 19 days. (😮🤯)
3/ Maternal immunoglobulins M are poorly transported through placental villi and the fetal secretory immune system starts producing immunoglobulin M around the 20th week of gestation.

eurosurveillance.org/content/10.280…
Read 18 tweets
Lots of colleagues & friends remain sore after the #FauciLeak on the interim #ACTT trial analysis that compared #remdesivir to placebo in patients hospitalized with severe #COVID19 2 days ago.

My thoughts on the events as a #clinicaltrials and #DSMB doctor—thread 1/10
Data Safety Monitoring Boards (#DSMB) are independent groups of doctors & statisticians that analyze unblinded data in clinical trials, key to assure safety of patients enrolled, think about it as a safety satellite or control tower for the blinded investigators & patients.
#DSMBs have an instruction set (charter) agreed on before the #trial starts, includes prespecified statistical analyses (very low p-values) and thresholds that would trigger stopping a trial early for efficacy (big beneficial effect), toxicity (harms), futility (wasting our time)
Read 12 tweets

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