Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts disq.us/t/3lo0wf6 - really nice work by @ETCirulli and colleagues 
@ETCirulli Provides yet more evidence that variation in our traits is NOT just caused by common variants. We all also carry many rare variants (some very rare or even private) that make very large contributions to our phenotypes
@ETCirulli The important effects of rare variants place limits on the usefulness of polygenic scores, which are based on profiles of common variants only and which give a very limited picture of genetic variation
