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"In the course of its review, the committee encountered many gaps and limitations in knowledge bearing directly and indirectly on the safety of vaccines. 1/
These include inadequate understanding of the biologic mechanisms underlying adverse events following natural infection or immunization,insufficient or inconsistent information from case reports and case series,...2/
inadequate size or length of follow-up of many population-based epidemiologic studies, and limited capacity of existing surveillance systems of vaccine injury to provide persuasive evidence of causation."
ncbi.nlm.nih.gov/books/NBK23629…
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