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Proof that social | physical distancing works for #COVID19 for mitigation of spread science.sciencemag.org/content/early/… @ScienceMagazine today
by @MOUGK @svscarpino and collaborators, via @hholdenthorp important evidence we've needed and need to heed
The 1918 influenza mitigation (St Louis) replicated by the 2020 #COVID19 (China)
pnas.org/content/104/18… by @mlipsitch and colleagues
Why social | physical distancing CANNOT be quickly or prematurely relaxed
Modeling for China's #COVID19 data
thelancet.com/journals/lanpu… @TheLancetPH
Fully backs up the @Science paper today on the big impact of this mitigation strategy
And fits squarely with @stuartathompson and @NickKristof
nytimes.com/interactive/20… model they just published @nytopinion on @POTUS's desire to "Reopen America"
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More from @EricTopol see all

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Eric Topol
@EricTopol
A few new graphs on US #COVID19 testing:
1. I've annotated @JoeHasel's important @OurWorldInData graph ourworldindata.org/grapher/cumula… that compared S Korea vs US. Both countries had 1st patient Dx w/in 24 hrs in Jan. For ~50 days there was very little US testing, the spread phase 1/3
2. In @nytimes on the US surge
nytimes.com/interactive/20…
what is missed is all of February when there were a grand total of 352 US tests vs >75,000 in S Korea
Meanwhile people broadly getting infected in the US but no ability to diagnose (or even suspect) @LazaroGamio @adeelnyt 2/3
3. And this March graph which also gives the misimpression on theUS surge, although not normalized (R panel). The key omission is timeline from Jan 21, 1st patient. And it's very likely there were people in the US infected in December, but missed before Seattle kicked in 3/3
Read 3 tweets
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Eric Topol
@EricTopol
A thread about having my #COVID19 test and serology today (all in 1) from blood in ~15 minutes. Picture of my sample which put on a dedicated chip and optically analyzed for coronavirus proteins and antibodies vs controls 1/x
The dedicated chip, the machine open, and closed
This was at Genalyte, a SanDiego company which has been doing immunoassays on such chips for several years, now adapted to #COVID19 in past 2 weeks.
I have no relationship (COI) 2/x
The number of proteins and antibodies that are assayed is pretty formidable including the #COVID19 spike peptide, the nuclear capsule (E coli and HEK), SARS, along with IgG and IgM antibodies. This can be displayed in real-time as the assays are in progress 3/x
Read 5 tweets
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Eric Topol
@EricTopol
A very simple curve that tells a tragic story
1. China w/ 4 times the population of the US was able to flatten their curve
2. The US has now blown thru China's case N (tip of the iceberg d/t no testing for 2 months) to be the #COVID19 epicenter
3. The worst is yet to come
the denialism of this simple curve and our (US) lack of learning from a region that was hit months before us is striking
the same people who are assailing Fauci now
"Fauci and .. Dr. Deborah Birx have become targets for political attacks from allies of the administration who are not qualified health advisers and don’t know what they are talking about. This is unacceptable."
@hholdenthorp @ScienceMagazine today
science.sciencemag.org/content/sci/ea…
Read 4 tweets

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Lindsay Wiley
@ProfLWiley
It's becoming increasingly clear that the really challenging thing about the public health response to #Covid19--the reason our horribly botched testing roll-out was so far from being up to the task, is that people who are infected, but asymptomatic play a huge role in spread.
science.sciencemag.org/content/early/…
That's also why the extreme social distancing and community mitigation strategies we're employing in many states now are necessary to get a handle on where the virus is circulating widely. govexec.com/management/202…
Read 14 tweets
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Aaron Richterman, MD
@AaronRichterman
.@EricMeyerowitz and my talk about #COVID-19 literature update today -

Slides: docs.google.com/presentation/d…

Recording:
dropbox.com/s/bj0bbvggh1jr…

Key points with slides, links to papers below 👇
Virology: most important structural protein S ("spike") protein required for cell entry; nonstructural protein RNA polymerase, helicase; viral proteases that cleave non-structural proteins (PLpro, 3CLpro). Cell entry via ACE2/non-endosomal path

Below=SARS
nature.com/articles/nrd.2…
Environmental viability in EXPERIMENTAL conditions - 3+ hrs aerosol (does not imply routine aerosolization by patients), up to 72 hours steel and plastic.

nejm.org/doi/full/10.10…
Read 45 tweets
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Dr. Sanjay Gupta
@drsanjaygupta
While we know the vast majority of #COVID19 patients have mild or no symptoms, it's hard to give exact numbers because we are likely not testing those people as often as those who get very sick. #coronavirus (1/10)
But we've learned a lot from one unfortunate situation -- remember the Diamond Princess cruise ship? #COVID19 -(2/10)
The cruise set sail on January 20 from Yokohama, Japan with roughly 3,700 passengers on board (3/10)
Read 10 tweets
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Kai Kupferschmidt
@kakape
For those following the confusion around #ibuprofen: @ScienceMagazine just published a letter. It’s a bit technical, but bottom line: "People taking NSAIDs for other reasons should not stop doing so for fear of increasing their #COVID19 risk.” h/t @hholdenthorp
@ScienceMagazine @hholdenthorp So: "until we have robust evidence, patients in chronic pain should continue to take their NSAIDs rather than turn to opiates.”
And: "Patients on ACE inhibitors should continue to take them rather than risk complications, such as stroke.”
science.sciencemag.org/content/early/…
@ScienceMagazine @hholdenthorp This is also @WHO advice. Spokesperson told me today: “At present, based on currently available information, WHO does not recommend against the use of ibuprofen.” So everyone take a deep breath and keep taking your meds. Update if and when anything changes.
Read 3 tweets
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dr muge cevik
@mugecevik
3rd THREAD:

Summarising unfolding research picture on #COVID19 as the outbreak enters its 3rd month with more data being reported out of China.

This thread compiles scientific data (with direct links to papers) on what we know so far on #COVID19 #SARSCoV2

#IDTwitter
You can see the major research outputs from the 1st month of the #COVID19 outbreak in this thread (48 tweets):



or in this thread reader: threadreaderapp.com/thread/1221020…
And see the updates from the 2nd month of the #COVID19 outbreak in this thread (32 tweets):



or in this thread reader:
threadreaderapp.com/thread/1226518…
Read 30 tweets
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Gretchen Goldman, PhD
@GretchenTG
My new @sciencemagazine piece with @HarvardChanSPH's @francescadomin8 calls out EPA leaders and science advisors for taking science out of air pollution standards. A THREAD: science.sciencemag.org/content/early/…
@sciencemagazine @HarvardChanSPH @francescadomin8 The EPA is chipping away at the scientific foundation for its ambient air pollutant protections on multiple fronts. My @sciam piece today is a good rundown: blogs.scientificamerican.com/observations/w…
@sciencemagazine @HarvardChanSPH @francescadomin8 @sciam Back in October, the EPA disbanded the particulate matter review panel, a key source of science advise to ensure EPA sets health-based standards. I wrote a thread on why that was bad here:
Read 12 tweets

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