Today we take a look at the Malmo Diet and Cancer Study published in 2007. This study was primarily to study cancer risk factors and looked at 28k people in Malmo, Sweden. They were followed for 5 years and food info was from 7 day diet entries.
The study did not record trans fat as a separate category, so most of the trans fats were counted as MUFA or PUFA. This is a pretty profound confounder and makes the study almost uninterpretable. journals.sagepub.com/doi/abs/10.109…
Another arm of the study actually looked at cancer death. 5-7 years is not a long study to examine cancer, but there was a statistically positive relationship between total dietary fat and cancer mortality in women.
Hardly good news for #LCHF promoters. onlinelibrary.wiley.com/doi/10.1111/j.…
Hardly good news for #LCHF promoters. onlinelibrary.wiley.com/doi/10.1111/j.…
As for cardiovascular mortality, the lowest quartile consumption was 13% calories from SFA. Once again, raising the temperature of a fire seemed to have no effect on the ashes, and so there were few statistically significant harmful or protective effects seen.
However, the authors did not mention a significant association in one of their analyses, the PUFA/SFA ratio in men was quite significant, showing that men who ate the highest SFA with low PUFA intake had higher CVD event rates. 
Because TFA was counted as MUFA or PUFA, it is unsurprising that MUFA showed a trend towards increased CV events as well. In the end, this is once again a very homogenous population (a single Swedish city), looked at for a rather brief time. Hard to draw any strong conclusions.
Tomorrow we will look at the Nurses' Health Study.
