Discover and read the best of Twitter Threads about #pdb

Most recents (12)

🧵#Bioinformatics in #drug #discovery and development, a THREAD🧵🧵:
#Bioinformatics is playing an increasingly important role in the discovery and development of new #drugs. In this thread, we'll explore how #bioinformatics is being used to identify new targets for drug intervention and optimize drug design.
One key aspect of #bioinformatics in drug discovery is the identification of potential #drug #targets.
Read 12 tweets
🧵#Bioinformatics and its impact on #healthcare, a THREAD🧵🧵:
#Bioinformatics is the application of #computational techniques to the analysis of #biological data, such as #DNA sequences and #protein #structures.
In #healthcare, #bioinformatics is used to gain insights into the #genetic basis of diseases, and to develop new #diagnostic tests and #treatments.
Read 11 tweets
Examples from our Protein Common Assembly Db now on @biorxiv_bioinfo with @QifangXu. Viable assemblies for all Xray structures (EPPIC, @josemduarte), clustered w/ cryoEM, NMR assemblies by Pfam architectures + stoichiometry+ symmetry + interfaces. @buildmodels @PDBeurope @pdbj_en
We count "Crystal forms (CFs)" - unique crystal unit cells or cryo-EM or NMR experiments for each cluster, and number of uniprot sequences across each cluster. More experimental data --> more support for relevance of biological assembly. Also #PDB's bioassemblies, PISA, EPPIC.
PCNA example from 1st tweet. Largest cluster (#8) of Pfam arch (PCNA_N)_(PCNA_C) has 28 crystal forms (CFs) out of 36 CFs for this Pfam architecture in whole in PDB (78%). 19 UNPs of 23 in whole PDB (83%). 55 entries of 64 in whole PDB (86%).…
Read 15 tweets
.@PressSec starts of briefing says neither the front page of the @nytimes nor the White House podium is a venue "for discussing classified information"

"We are here having this discussion today because of an irresponsible, anonymous leak"
"There is no good scenario as a result of this New York Times report" per @PressSec

"Who's going to want to cooperate w/the United States intelligence community? Who's going to want to be a source or an asset if they know that their identity could be disclosed"
NEW: "This report makes it more difficult to come to a consensus on this matter" @PressSec says of report on alleged #Russia|n bounties

She also warns, "This level of controversy & discord plays directly into the hands of #Russia & unfortunately serves their interests"
Read 10 tweets
#MDSI2019 Day2 Session 2: "Standardization of file format I/O" by @jppiquem.

Straight into problems -- input files are a tougher cookie to crack than output 🍪
Actually, Day 2 Session 3 #hasphdcantcount
#Input: Many problems -- many possible solutions! How to find the right one? #goldilocks

#Output: probably easier to handle and we can learn from other fields, like climate research.
Read 21 tweets
1/ #Django will use watchman to do autoreload if it's installed since 2.2. The default reloader runs stat on all the files in your project once per second, whereas watchman will use os file system events, which is much more efficient.
2/ I never cared about this until I spent an afternoon figuring out why Docker for Mac's hyperkit process sits on 120% - 150% cpu use while running my mid sized django project in a container.
3/ i used 'docker stats' to deduce which container, then 'top' and 'ps auxf' to work out which python process was the problem. Then did a thread dump of the django server using faulthandler.dump_traceback() triggered from an API call, and then 'docker log'
Read 7 tweets
The campaign news is all about the Benjamins today with breakdowns of the Q2 totals in the news. @PeteButtigieg is in Kansas City for a Grassroots Event at 7pm. Here's today's #PDB:
.@PeteButtigieg interview on Kansas City station @kcur:…
.@nytimes analyzes fundraising numbers:…
Read 8 tweets
.@PeteButtigieg had a successful weekend campaigning in New Hampshire and Iowa. He's in South Bend today doing mayor stuff such as opening a new firehouse. Here's the #PDB:
Read 7 tweets
If you’ve ever wondered why one of the most secretive organizations in the world is committed to #transparency, or how we go about protecting American’s privacy & civil liberties, keep reading.
Ben Huebner runs CIA’s Privacy & Civil Liberties Office.

His job is to look at our programs & practices to make sure we’re living up to our commitment to safeguard American’s privacy & civil liberties.

He’s also leading CIA’s efforts to increase #transparency.
CIA’s mission & the safety of the men & women who contribute to it will always require certain information to be #classified.

The key is there needs to be a real, identifiable, justifiable reason why that fact, that method, or that source needs to remain secret.
Read 6 tweets
#PDB is primary vehicle for summarizing day-to-day sensitive intel & analysis for @WhiteHouse on current & future national security issues.
Style, format & presentation of #PDB are based on preferences of @POTUS. Mr. Obama asked for it electronically. Image
Mr. Nixon, once practicing attorney, liked to review #PDB on long legal size paper. This format was carried into the Ford administration.
Read 6 tweets
24 AUG: Declassified Nixon & Ford PDBs to be released @ event held @NixonLibrary

CC: @Ford_Library
Nixon & Ford PDBs to be released @ symposium entitled “The President’s Daily Brief: Delivering Intelligence to Nixon and Ford.”
28,000 pg #PDB release includes intel provided by CIA to @POTUS during:
Vietnam War
Nixon’s Trip to China
OPEC embargo
Arab-Israeli War
Read 3 tweets
April 1996: James M. Lewek was killed in a plane crash near Dubrovnik, Croatia.
#inmemoriam Image
Jim a native of Cheektowaga, NY held a BA in Econ from @Cornell & completed course work for a PhD in Econ from @VanderbiltU.
1975: Jim joined CIA & learned craft of economic intel analysis by working on some of the most formidable hard-target countries.
Read 12 tweets

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