Discover and read the best of Twitter Threads about #computational

Most recents (5)

Can computational methods assess the #sentiment of complex texts? In an article with my fabulous colleagues from the @WZB_Berlin, @unipotsdam @LMU_Muenchen @JungeAkademie, we answer this question by applying #dictionary and #scaling methods on a sample of #literature reviews🧵
The article is also a practical #guide to help researchers select an appropriate #method and degree of preprocessing for their own data. Our #corpus consisted of 6.041 summaries of reviews of contemporary German #literature acquired from @perlentaucher00 (2/9)
The linguistic #complexity of #literature reviews differ from other texts with regard to their #language-- ambiguity, irony, metaphors, etc.-- are comparatively difficult to capture with #computational approaches. So how did our different methods fare? (3/9)
Read 9 tweets
1/ Excited to share how T cell therapies kill #leukemia!! multi-omics + new #computational #singlecell tools for longitudinal analysis 👉unexpected answer!…

*👏* @elhamazizi! 🙏 @dpeer Cathy Wu @MDAndersonNews @CPRITTexas @ColumbiaBME @sloan_kettering
2/ We studied donor lymphocyte infusion (DLI) - an #Immunotherapy for relapsed #leukemia after #BMT & the #og of #celltherapy. Previously, we showed DLI reversed T cell exhaustion - but didn't know why/how/which T cells were responsible...…
3/ To address these ?'s, we modeled intraleukemic T cell dynamics by integrating longitudinal, multimodal data from ~100K T cells (!) during response (R) or resistance (NR: nonresponder) to DLI.
Read 18 tweets
🎉CELEBRATION ALERT!! We reached 10K followers @NatureCancer - massive thank you to our wonderful community for the warm welcome! Given it is also 10 months of our online life, here are some of our best articles (although all are *fantastic*) #thread 1/n

January @NatureCancer: Nabel &co @SanofiUS develp #trispecific antibodies against CD3, CD28 and CD38, with preclinical efficacy and safety in humanized mice and NHPs 2/n

February @NatureCancer: Golub and Co @broadinstitute develop PRISM, a tool for non-oncology drug repurposing in #cancer 3/n

Read 12 tweets
And so it begins @ThomasAastrup 🤓🤓🤓
Det her fortjener sin helt egen artikel ift verserende dagsordener om teknologiforståelse, computational thinking og fremtidens arbejdsmarked - skolen er netop for det modsatte - teknologifantasien, -forestillingen & -forundringen -at putte teknologien på bordet og undres med den
Teknologifantasi som en indre fabuleren af mulige dystopier og utopier frem mod en ønskværdig verden & teknologikreation som en ydre fabrikation af verdener frem-stillet som dialoger, udkast og værker:en form for teknologileg og -filosofi på kanten af verden
Read 23 tweets
Hello #dendrites friends! Check out our new paper, published at @NatureComms : "Challenging the point neuron dogma: FS basket cells as 2-stage neural networks.…
Briefly, we predicted through #computational simulations that the #dendrites of #Fast_spiking #interneurons in #Hippocampal #CA3 and #PFC areas come in two #nonlinear flavors: Supralinear and sublinear!
This bimodal nonlinear behavior is determined by differences in the morphology (volume) of the dendritc branches. These differences can causally enable or prohibit the existence of #sodium_spikes. Interestingly, both types coexist in all model neurons tested!
Read 8 tweets

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