, 7 tweets, 14 min read Read on Twitter
So @ANZUPtrials #ENZAMEt #PCSM results fro #HRQOL were presented today at #ESMO19, here are some of the headline outcomes 1/5 #InternationalCollaboration #RCT
@ANZUPtrials Acknowledgements usually come last but we can't do these studies without #patients. So our very sincere thanks to the 1125 men living with mHRPC #PCSM who volunteered to take part, have the treatment, & fill out #HRQOL questionnaires! #ENZAMET @anzupartners #ESMO19 2/5
@ANZUPtrials @anzupartners In the @ANZUPTrials #ENZAMET study we measured #HRQOL using @EORTC_QLG's #QLQC30 (global qol, social, physical, emotional, functional domains) & Prostate Cancer module #PR25 at weeks 0, 4, 12, then 12-weekly until clinical progression #PCSM #ESMO19 3/5
@ANZUPtrials @anzupartners @EORTC_QLG Graphs below show effects of adding enzalutamide vs conventional NSAA on #HRQOL and deterioration‐free survival @ANZUPTrials #ENZAMET #PCSM; global #HRQOL & Global health was not impaired by treatment, although #fatigue #CognitiveFunction #PhysicalFunction were more impaired 4/5
@ANZUPtrials @anzupartners @EORTC_QLG So far what we know is adding #ENZA:
- maintained global health & global HRQL
- improved deterioration-free survival because early impairments in specific aspects of #HRQOL were insufficient to outweigh benefits of delayed clinical progression
@ANZUPtrials #ENZAMET #ESMO19 5/5
@ANZUPtrials @anzupartners @EORTC_QLG @ANZUPtrials #ENZAMET A few more points(5 not enough!), adding #ENZA:
- associated with #DFS benefits at 3 yrs, smaller with
early docetaxel than without it, but differences not beyond the play of chance
@ANZUPtrials @anzupartners @EORTC_QLG @ANZUPtrials #ENZAMET A few more points (5 not enough!), adding #ENZA:
- to testosterone suppression alone is appropriate option for men with mHSPC starting testosterone suppression alone #ESMO19 #HRQOL 7/5
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