Discover and read the best of Twitter Threads about #rct
Most recents (24)
I want you to know that Alzheimer's disease-alleviating, neuroprotective effects of vitamin D have been replicated in recent clinical trials. (1/7) #AD #Alzheimers #VitaminD
In a 12-month randomized, double-blind, placebo-controlled trial, these researchers showed that compared to the AD group w/placebo the AD group w/vitamin D supplement (800 IU/day) had a significant reduction in plasma Aβ42 and related biomarkers. (2/7) #RCT #science #research
Plasma Aβ42 is a biomarker that is often used to diagnose Alzheimer's disease and track progression. It's a protein that accumulates in the brain and leads to the formation of amyloid plaques that can damage brain cells and disrupt cognitive function. (3/7)
1) Welcome to a new #accredited #tweetorial, "Utilizing Immunohistochemistry Testing, Biomarkers, and Targeted Therapeutics to Optimize Outcomes in Patients with NSCLC," featuring the highlights of a symposium presented at the #ESMOIO22 congress.
@myESMO #LCSM #FOAMed
@myESMO #LCSM #FOAMed
2) The faculty for this outstanding program were @peters_solange (Chair) 🇨🇭, @HosseinBorghaei 🇺🇸, Natasha Leighl MD 🇨🇦, and @dplanchard 🇫🇷. A truly international roster of experts in #oncology!
Don't miss prior accredited courses in this space at oncologytweetorials-ce.com/category/lung-….
Don't miss prior accredited courses in this space at oncologytweetorials-ce.com/category/lung-….
3) This program is supported by an educational grant from Sanofi. Statement of accreditation and author disclosures are at oncologytweetorials-ce.com/disclosures/.
1/
Is it ethical to interrupt a #RCT early because the treatment group is doing too well?
In my opinion NO
Here is a practical example
Is it ethical to interrupt a #RCT early because the treatment group is doing too well?
In my opinion NO
Here is a practical example
2/
Adding #pyridostigmine to standard care reduced mortality among patients hospitalized for severe #COVID19
in Mexico a small study of 94 patients per group performed in hospitalized, severe (on oxygen, but not intubated) #covid19 patients
molmed.biomedcentral.com/articles/10.11…
Adding #pyridostigmine to standard care reduced mortality among patients hospitalized for severe #COVID19
in Mexico a small study of 94 patients per group performed in hospitalized, severe (on oxygen, but not intubated) #covid19 patients
molmed.biomedcentral.com/articles/10.11…
3/
The magnitude of the effect apoparently is >glucorticoids >tocilizumab >paxlovid
And much much more than all the minor things which still excite covidiots (eg #ivermectin #hydroxychloroquine … )
The magnitude of the effect apoparently is >glucorticoids >tocilizumab >paxlovid
And much much more than all the minor things which still excite covidiots (eg #ivermectin #hydroxychloroquine … )
Thread Alert 🧵: Let's talk about Parkinson's Disease 1/25 #Parkinsons #neurotwitter
In 2005 there was this study that, although very small, showed benefits. "Unified Parkinson’s Disease Rating Scale scores improved in all five during hyperketonemia" 2/25
n.neurology.org/content/64/4/7…
n.neurology.org/content/64/4/7…
It wasn't designed to rule out a placebo effect. But the result should have resulted in excitement and further studies being done. 3/25
Would you like to know about a randomized crossover trial that used a modified #ketogenic diet in #Alzheimers disease? 1/9
26 patients with clinically confirmed #Alzheimers disease were randomly assigned to a modified ketogenic diet or a usual diet supplemented with low-fat “healthy” eating guidelines and enrolled them 2/9
in a single-phase, assessor-blinded, two-period crossover trial. That means (2) 12-week treatment periods, separated by a 10-week washout period. 3/9
If you have Alcohol Use Disorder, consider speaking with a psychiatrist trained in the use of ketogenic diets. (1/7) #RecoveryPosse #Alcoholism #Alcoholic #metabolicpsychiatry
A 3-week RCT done by the National Institute of Alcohol Abuse and Alcoholism found that a ketogenic diet could reduce the need for detox medications. (2/7) #Journal #Research #PeerReviewed #ThisIsPublicHealth #RCT
They also found that a #ketogenicdiet reduced both #alcohol withdrawal symptoms and reduce alcohol cravings. (3/7)
1a) Welcome to a new #accredited #tweetorial, “MOA and Clinical Trial Data for Novel & Emerging Therapeutic Strategies for #HCM: Can We Target Our Therapy?"
1b) Our expert (and returning @cardiomet_ce) author is Giuseppe Galati MD, MMSc in Heart Failure, FHFA, @GiuseppeGalati_ , Consultant #Cardiologist #HeartFailure & #Cardiomyopathies
2) @GiuseppeGalati_ is in Milan 🇮🇹 This program is intended for #healthcare professionals & is accredited for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists.
1) Welcome to our #accredited #tweetorial on clinical trial results and emerging data for treatment of Diabetes and CKD #DM in #CKD. I am Brian Rifkin MD, @brian_rifkin, from the Hattiesburg Clinic. #Nephtwitter #Medtwitter #FOAMed
2) This #accredited #tweetorial series on #kidneydisease #CKD is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US- or UK-based HCPs. Accreditation statement & faculty disclosures at ckd-ce.com/disclosures/.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Prior programs in this series, still eligible for CE/#CME, can be accessed at ckd-ce.com. FOLLOW US to learn from expert faculty!
Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial thelancet.com/journals/lance…
We found that the higher dose did not reduce the risk of recurrent #VTE during the entire study period (Pregnancy plus postpartum period), which was unexpected and perhaps due to an over-enthusiastic sample size calculation…
NEXT : @AriErcole
Association is not necessarily a causation
RCTs are thought of as "gold standard" for a good reason.
"Randomisation" eliminates influences of confounders.
- allows "causality" inference.
Association is not necessarily a causation
RCTs are thought of as "gold standard" for a good reason.
"Randomisation" eliminates influences of confounders.
- allows "causality" inference.
@AriErcole RCTs require relatively little prior knowledge.
But
"DO WE HAVE ASSURANCE OF THIS" ?
we try to "by having a inclusion criteria"
🧐 we can only control what we know
RCTs have limitations - dont really imply causality absolutely.
@ESICM #datascience #ai #ml #icudata #RCT
But
"DO WE HAVE ASSURANCE OF THIS" ?
we try to "by having a inclusion criteria"
🧐 we can only control what we know
RCTs have limitations - dont really imply causality absolutely.
@ESICM #datascience #ai #ml #icudata #RCT
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures & accreditation statement are at ckd-ce.com/disclosures/. FOLLOW US!
For those who can't get enough from #ADVOR, below the promised Tweetorial!
Acetazolamide in acute #HeartFailure w volume overload on background high-dose loop diuretics:
👍Increases diuresis & natriuresis
👍More euvolemia after 3 days & discharge
👍⬇️LOS
#ESCCongress #Cardiology
Acetazolamide in acute #HeartFailure w volume overload on background high-dose loop diuretics:
👍Increases diuresis & natriuresis
👍More euvolemia after 3 days & discharge
👍⬇️LOS
#ESCCongress #Cardiology
First, the unsung hero's of this trial, done with a little bit over 2 million €, bargain for largest diuretic #RCT ever!
@KatrienTartagl2 & her team, with only 3FTE, they ran the most successful trial in #AHF
@PieterMartensMD & @JeroenDauw who did most fieldwork
👏
@KatrienTartagl2 & her team, with only 3FTE, they ran the most successful trial in #AHF
@PieterMartensMD & @JeroenDauw who did most fieldwork
👏
How did we come up with the idea? Actually, cause we all love #physiology. Credits go to Prof. Em. Paul Steels who teached us all how kidneys work.
@GLW_UHasselt
65% of sodium is reabsorbed in the proximal tubules, can be up to 85% in #HeartFailure
@GLW_UHasselt
65% of sodium is reabsorbed in the proximal tubules, can be up to 85% in #HeartFailure
Does blinding work in #antidepressant #RCT? Recently there were 2 papers on this topic with opposite conclusions. A🧵on #blinding and why #robustness #DataAnalytics may lead to better #science
The two papers are tinyurl.com/2p9atk4t (p1; by @AmeliaJScott, @LSharpeUSYD and @BenColagiuri) and tinyurl.com/mtmtx7m3 (p2; by @Toshi_FRKW and colleagues).
Their two conclusions:
-p1: "meta-analysis suggested that blinding was unsuccessful among participants and investigators."
-p2: "patients or assessors were unlikely to judge which treatment the patients were on."
-p1: "meta-analysis suggested that blinding was unsuccessful among participants and investigators."
-p2: "patients or assessors were unlikely to judge which treatment the patients were on."
1) Welcome to a new #accredited #tweetorial, Prevention and Management of Heart Failure in T2 Diabetes: The Cardiologist’s Perspective! Our expert author is Giuseppe Galati MD, MMSc in Heart Failure, @GiuseppeGalati_ , Consultant #Cardiologist #HeartFailure & #Cardiomyopathies
2) @GiuseppeGalati_ is at San Raffaele Research Hospital, Milan 🇮🇹 @SanRaffaeleMI. This program is intended for #healthcare professionals & is accredited for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists 🇺🇸🇨🇦🇬🇧🇪🇺.
3) @cardiomet_CE is supported by educational grants from AstraZeneca, Bayer, Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company, & Chiesi. Earn credit from archived programs at cardiometabolic-ce.com. Disclosures at cardiometabolic-ce.com/disclosures/.🙏 FOLLOW US !
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
1) Welcome to our new #tweetorial on optimizing #interprofessional & #multidisciplinary care & medical therapy for patients with #DKD. I am Sophia Ambruso DO, @Sophia_kidney, from @CU_kidney.
2) This #accredited #tweetorial series on #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers. Faculty disclosures are at ckd-ce.com/disclosures/.
3) This activity is accredited for 0.75h credit for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. FOLLOW US for more programs by expert faculty!
1) Welcome to @cardiomet_CE's new series on #lipid management! This is a 10-#tweetorial program, all #accredited, that will cover it all. Our first expert author is Paul Thompson MD @PaulDThompsonMD, esteemed #cardiologist from @hartfordhosp @UConn Med & now @MGHHeartHealth !
2) This #tweetorial, accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists is supported by an educational grant from Esperion Therapeutics. See faculty disclosures at cardiometabolic-ce.com/disclosures/.
3) @PaulDThompsonMD took on education re mechanisms & use of ezetimibe & bempedoic acid. He proposes a case: 45 ♂️ w/history of inferior wall #MI treated with primary angioplasty.
Join us tomorrow for the launch of a new accredited tweetorial – a case-based program on the assessment and management of patients with IgA #nephropathy (#IgAN). Free CE/#CME for #physicians, #nurses, #pharmacists! Expert author none other than @IgAN_JBarratt. FOLLOW US . . .
. . . and tell your colleagues to join you here on @ckd_ce, your ONLY source for accredited #tweetorials in the #CKD space! #nephtwitter #nephjc @nephondemand @Nephro_Sparks @edgarvlermamd @ChristosArgyrop @goKDIGO @nicklimd @CKJsocial @ERAkidney @kidney_boy @kidneypathology
1) Welcome to our accredited #tweetorial on optimal contemporary mgt of #IgAN. Earn 0.5h CME/CE credit #physicians #nurses #nursepractitioners #physicianassistants by following this thread. I am @IgAN_JBarratt. @MedTweetorials #nephtwitter #nephjc #FOAMed #MedEd
1) Welcome to our new #accredited #tweetorial on #mechanismofaction & impact of meds commonly used in patients with or at risk for #DKD progression: #MRAs, #GLP-1 receptor agonists & #DPP-4 inhibitors. I am Sophia Ambruso DO, @sophia_kidney, from @CU_Kidney.
2) This #accredited #tweetorial series on #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
🔻🔻Live in a few minutes ⌛️
#ClinicalTrialsMasterclass
🫀Designing trials in antiplatelet therapy, with @Drroxmehran @DjawidHashemi @aayshacader
🔗
@KardiologieHH @ANazmiCalik @mirvatalasnag @Hragy @mmamas1973 @vass_vassiliou #CardioTwitter #DAPT
#ClinicalTrialsMasterclass
🫀Designing trials in antiplatelet therapy, with @Drroxmehran @DjawidHashemi @aayshacader
🔗
@KardiologieHH @ANazmiCalik @mirvatalasnag @Hragy @mmamas1973 @vass_vassiliou #CardioTwitter #DAPT
🧵THREAD
In honour of the #Hernia2021 congress hosted by the BJS strategic partner @eurohernias, here is a thread of recent hernia-related BJS papers.
In honour of the #Hernia2021 congress hosted by the BJS strategic partner @eurohernias, here is a thread of recent hernia-related BJS papers.
European Hernia Society guidelines on management of rectus diastasis #rectusdiastasis #Hernia2021 #Hernia
academic.oup.com/bjs/advance-ar…
academic.oup.com/bjs/advance-ar…
Reporting guideline for interventional trials of primary and incisional ventral hernia repair #OpenAccess #Hernia2021 #Hernia #VentralHernia
academic.oup.com/bjs/article/10…
academic.oup.com/bjs/article/10…
More info on the @CancerPrev_KCL & @CR_UK-run NHS-Galleri™ #screening trial:
kcl.ac.uk/news/kings-lea…
cancerresearchuk.org/about-cancer/c…
Worth noting you can't #volunteer for this trial, but if you are 50-77 & haven't been diagnosed with cancer in the past 3 years, you may be #invited...
kcl.ac.uk/news/kings-lea…
cancerresearchuk.org/about-cancer/c…
Worth noting you can't #volunteer for this trial, but if you are 50-77 & haven't been diagnosed with cancer in the past 3 years, you may be #invited...
The NHS-Galleri™ #screening trial is a proper #RCT, which means half of the 140,000 participants WON'T be tested (certainly not in the initial phase) and NONE will be told whether they have been #tested or not.
Of course if the test indicates *possible* markers for #cancer...
Of course if the test indicates *possible* markers for #cancer...
...then you will be contacted by the trial nurse by phone, and will be referred to an NHS hospital for further tests.
So every participant in the NHS-Galleri™ #screening trial should still attend standard screening & should contact their GP if they notice any unusual symptoms:
So every participant in the NHS-Galleri™ #screening trial should still attend standard screening & should contact their GP if they notice any unusual symptoms:
What to do when you're analysing data arising from a Randomised Controllled Trial (RCT) and you have noncompliance in the treatment group?
A thread on Complier Average Causal Effect (CACE) modeling... /1
#Stata #RCT #CACE #gsem
A thread on Complier Average Causal Effect (CACE) modeling... /1
#Stata #RCT #CACE #gsem
In RCTs, we compare the outcome in the treatment and the control group. When everyone in the treatment receives the treatment in full or (comply), trial arm assignment is enough to estimate the effect of the intervention. We call this "intention-to-treat" (ITT). /2
The problem is that some participants may not receive the treatment in full or comply with all the requirements of the intervention itself. This produces bias in the ITT estimate, "diluting" the effect of the intervention, which is why we need to account for noncompliance. /3
Our #RCT of #azithromycin vs placebo for outpatient #COVID is out today in @JAMA_current
Tl;dr – azithromycin doesn’t help improve symptoms in outpatients with COVID and might make things worse, so don’t use it. 1/n
jamanetwork.com/journals/jama/…
Tl;dr – azithromycin doesn’t help improve symptoms in outpatients with COVID and might make things worse, so don’t use it. 1/n
jamanetwork.com/journals/jama/…
Why did we do this study? Azithromycin was identified early on as a potential candidate for COVID (+/- HCQ). Although it’s relatively safe, antibiotic use causes antibiotic resistance, and unnecessary widespread use of an antibiotic is a bad call. We need to know if it works. 2/n
There were some reasons to think it MIGHT work: azithromycin has anti-inflammatory properties and is used in other pulmonary diseases to reduce inflammation and has some in vitro anti-viral properties. But that doesn’t necessarily translate to efficacy, so we need a trial. 3/n
