Here is an example of exactly HOW NOT to design a study and publish.
A grp of #ayurveda vaidyas published:💡Clinical Improvement In #COVID19#patients With Timely Intervention Of Panchagavya: Preliminary Finding
💵International Journal of Pharmacological Research 1/n #MedTwitter
First, choice of #journal. Choose one indexed in valid scientific databases - eg @Scopus, Medline @NCBI, @embase, @EBSCO, @webofscience. International Journal of Pharmacological Research is indexed👇😶
Just bcoz its on Google doesn't mean its quality. #pseudoscience#fake 2/n
There R indexed and impactful journals charging #openaccess fee (eg @JHEP_Reports) if the institute can afford it. Most quality indexed, impactful journals (eg @HEP_Journal) dont have open access fee to publish, but #Subscription fee for persons to read #published study. 3/n
The current journal, The International Journal of Pharmacological Research - isnt indexed, doesn't have an impact factor, no valid presence in scientific repositories, has a blurry editorial board charging an open access fee - the making of a #PredatoryPublishing STAY AWAY. 4/n
Now the study and obnoxious results: #Gomutra or distilled #cow urine was given, along with prescribed medications to three very mild COVID-19 positive patients. All three recovered from #COVID19 with no #complications. That's it. That's the study and its conclusions. 5/n #ayush
So what is wrong?
First, case study/series must have an intro section providing insight, references 2 previous work which made possibl current work. In this study, authors hav written non-structured BACKGROUND (with study conclusions!) followed by INTRODUCTION which is nuts. 6/n
Methodology is quite hilarious.
All 3 patients wit #coronavirus (patient+2 fam members) were treated 'telephonically' - i.e, they were told over the phone to take distilled cow urine 'while they are at home'. This means, tat #Covid infection was very mild at outset #science 7/n
Once they were confirmed #SARSCoV2 , underwent admission to a Covid hospital at Nagpur and underwent ultra-proper treatment (they got every thing undr the sun along wit cowurine). After gov hospital based treatment they were deemed #Covid -ve & send home
All medications 👇😱 8/n
Finally, authors conclude that cowurine improved immunity (how it did is up2 readers fantasy) and all patients recovered wit cow urine. They then dive into the imaginary reasons why this is so, in the process, stretching readers imagination and then, sudenly discus #Cancer! 9/n
Im not sure why cow urine was used, and not human urine. Both hav similar composition, properties. Human urine easily available, people can donate free. Collection jars at public urinals ensure steady flow 4 clinical use. This discussion is missing from limitation section😵 10/n
The authors finally call 4 population study on cow urine FOLLOWED BY in-vitro study. Interesting reverse science. They conclude that comorbidly ill patients with #coronavirus recover with cow urine, based on family study of 3 who received all treatments under the Sun. 11/n
So wat is conclusion!? If you hav #COVID19, esp mild #Disease, call #cowurine#Ayurveda helpline, buy distilled cowurine packs, go 2 nearby modern hospital, get treated, get well. Witout drinking, jus holding on2 urine pack in a proper hospital promotes wellness as well. 12/n
But let us not belittle urine so much. It has potential, as another study shows (Sreedevi et al , IJPP 2016)
When human urine used wit farmyard manure, mazie crops grew better than wit cow urine. Its time for another #ayush team to look into this combo therapy in #COVID19 13/n
I asked the son, who was flustered and trembling, looking at his father lying on the green sheet ER bed
"What happened?"
Trying to cover his shame, but not the disgust, he replies, "This has never happened before"
"What?" I ask him
"My father defecated on the dining table"...
..."in front of us, in front of my cousins"
"& then what did u do?", I ask him
"I tried to pull him down & then
...he called me son of a bitch"
"My dad's never been abusive, he's the sweetest person"
"What did the ER doc at the 1st hospital tell you?"
& he says, "Ammonia"...
The young man's father was at his nephew's celebrating a birthday party, had a hearty and meaty dinner and went to bed late
Early morning, he woke up groggy. He was muttering and murmuring. Even though he identified his wife, he could not name her and his speech was slurred...
28 y old young mother is referred for evaluation of progressive jaundice
Docs are mind-boggled
Patient is getting sicker - increasing jaundice/persistent itching 2 mo after delivering healthy baby girl
She's scared, of the possibility that she wont get to see her baby girl...
...bcoz her primary care GP, while referring to our tertiary center, also hinted at the possibility of liver failure and need for liver transplant
Their diagnosis - post delivery unknown cholestatic viral hepatitis, possibly hepatitis E infection
But it didnt seem right...
...cholestasis means stagnation of bile inside liver - due to issues within the liver (hepatitis, bile duct damage) or outside liver (block in bile ducts due to stone, tumor)
This young mother had no obstructive features to bile flow, but her liver tests had shown...
...Analysis was done by an independent lab approved by the central and state government for food analysis and NABL accredited for general testing in chemical and biological parameters
Gas Chromatography/Mass Spectrometry, method was used to identify different substances...
...rather than conclude based on analytical findings, I wud like to know whether these findings r NORMAL for a protein supplement?
Herbalife supplements unlike other pure proteins, use herbal components 2, mayb this would have led to complex results... @minicnair@PriyankaPulla
Grateful to @AASLDFoundation,@AASLDtweets for recognizing our work @DDWMeeting & choosing us as one among ten to receive the prized Foundation Fellow Award globally
AASLD's recognition has been instrumental in progression of our clinical research in our State & Nation+ #DDW2022
Our featured works to be presented at the @DDWMeeting, San Diego May 21-24 include:
A. Use of high dose probiotics in patients with severe alcohol-liver disease where we discuss novel findings associated with intestinal microbiome and their interactions after probiotic therapy +
& B. The changes in fungal communities in intestines of patients with severe alcohol-liver disease treated with high dose probiotics (Poster of Distinction)
Were the changes beneficial?
How did bacterial communities interact with fungal communities?
58y old man with chronic liver disease is rushed to ER very early morning after multiple seizures, loss of consciousness
Blood glucose was 32mg!
A diabetic since long, he was on the same oral medications since last 2y
Why did a stable diabetic go into severe hypoglycemia...
...and why was his liver tests highly abnormal with jaundice and hepatitis
Bilirubin 4.8
AST 346
ALT 228
ALP 444
GGT 288
Even though abnormal liver tests are common after seizures, jaundice is unexpected, very rare
Which meant, this was more than just a hypoglycemic seizure...
Overweight and with diabetes, he was advised low calorie diet, weight loss and blood glucose control to prevent worsening of underlying chronic liver disease/cirrhosis
In early cirrhosis, controlling or treating cause(s) of cirrhosis helps prevent disease progression...