Discover and read the best of Twitter Threads about #teamscience

Most recents (8)

Our new paper is on biorxiv! "Predicting master transcription factors from pan-cancer expression data" biorxiv.org/content/10.110…. We set out to find master TFs in ovarian cancer, and went on quite a journey... A few highlights in the thread 1/
Prioritizing candidate MTFs without ChIP-seq data is tough, so we developed a gene expression-based approach which we loving called the Cancer Core Transcription factor Specificity (CaCTS) algorithm 🌵. (We then decorated the lab in cactuses) /2
Using CaCTS we identified candidate MTFs for 34 major tumor types and 140 molecular/histologic subtypes.

Candidate MTFs tend to be associated with super-enhancers, and many are lineage-specific essential genes - woo CaCTS works! 3/
Read 10 tweets
Launching the Navigating Team Science professional development workshop at #SfN19 is @anne_churchland talking about the @IntlBrainLab. Their goal is to develop a brain-wide model of decision making with 21 PIs. 👇
The team is international and all labs have at least one postdoc/student on the project. Each one leads a subproject so that they can have first author publications. There are multiple staff scientists and project manager to coordinate data and work.
There are external staff scientists that assist with the more complex aspects of data sharing and this is important because this expertise may not be present in individual lab. #teamscience
Read 10 tweets
1/ for what it’s worth, I don’t think being nice is strictly about pleasing others and being courteous. For me, it’s also about professionalism, easy collaboration, and inviting challenge. In fact, that last one might be the most important, particularly with #Science...
2/ I want to be receptive on every counter idea to my own. This is why invest so much time speaking to those with opposing views. I want to understand where they’re coming from and why. Many of my strongest opinions came from trying to defend its opposite unsuccessfully...
3/ And I’m certainly not perfect at this, I always feel like I could do a lot better.

Sometimes a friendly debate goes south and I spend the rest of the day thinking about what I could do or say differently to keep that from happening in the same way again.
Read 9 tweets
Thread hommage à @pierre_jacquel dont l'argumentation pourrait permettre de vendre n'importe quoi, tendant au passage à mettre en avant les sophismes qu'elle contient. @Ascl_Pios , @ContactPrimum , @TroncheBiais , @UnMondeRiant , et tout les médic et zet', dédicaces pour vous
Petit thread pour expliquer pourquoi je suis plutôt pour le remboursement de la raclette, et pourquoi je pense que toute personne qui aime (vraiment) la démarche scientifique devrait être de mon avis.
L'affaire semble pourtant simple : du coté de la #team science, on explique que la raclette n'a aucun effet en dehors d'un effet placebo. Les arguments sont nombreux.
Read 40 tweets
Petit thread pour expliquer pourquoi je suis plutôt pour le remboursement de l'homéopathie, et pourquoi je pense que toute personne qui aime (vraiment) la démarche scientifique devrait être de mon avis.
L'affaire semble pourtant simple : du coté de la #team science, on explique que l'homéopathie n'a aucun effet en dehors d'un effet placebo. Les arguments sont nombreux.
Certains (comme @le_science4all ) mettent l'accent sur le fait que les principes de l'homéopathie (mémoire de l'eau, etc) violent ce que nous savons de la physique moderne. Il y a pour la #teamBayésienne de très fortes raisons de ne pas croire en son effet.
Read 39 tweets
Missed the talk? Here's a summary of latest data on the selective next-gen TRK inhibitor LOXO-195 (BAY 2731954). On-target resistance to current inhibitors driven by kinase mutations in 3 positions (SF, xDFG, GK) - SF likely most common. #AACR19 @sloan_kettering @AACR 1/x
LOXO-195 evaluated in 2 programs: formal Phase 1 dose escalation and @FDAOncology #ExpandedAccess program đź‘Ź (for pts unable to enroll in P1). Here's the key eligibility and combined patient demographics. 15 tumor types. 30 pts TRKi resistant, 1 intolerant. 2/x
Patients were enrolled regardless of specific TRKi resistance mechanism - so it was important to retrospectively define. This was done by: 1) local tissue sequencing and/or 2) central cfDNA - summary below. 3/x
Read 8 tweets
How about a thread on #teamscience and collaboration, #academictwitter? I taught a team science class for jr investigators for years and have numerous research collaborations myself. Here are some common issues we discuss (and try to avoid!) when doing team science. 1/x
Avoid bringing collaborators into a grant application at the last minute--- “PO says we need an X and that’s you so can I add you? It’s due Monday.” You’ll get nothing substantive from this person since there is no time. It will show. 2/x
Don’t ignore the feedback of collaborators. If you decide to go a different way of their suggestion, it's ok just explain why. It will feel like a waste of time if they went through your grant and they feel you ignored their input. This could lead them to disengage. 3/x
Read 14 tweets
I've been lucky to grow up academically around many #prostatecancer scientific 'big machers' & helped with early cancer genomic maps over the last 5+ years, e.g.:
1) rdcu.be/Kw8d (@Chris_Barbieri1)
2) cell.com/cell/fulltext/…
3) cell.com/abstract/S0092… (@NCIgenomics)
About two years ago, @stephanie_mul tallied the whole exome data we had & mapped it against theoretical power calculations @gaddyg set forth for discovering significant cancer genes in any cancer type (see: ncbi.nlm.nih.gov/pubmed/24390350)
Read 11 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!