Thread by @LDLSkeptic

Day 2 Statin Adverse Effects:
Please RT to Dayspring & Peter Attia (Both block me)
Increased Brain Amyloid with Statins
dx.doi.org/10.1016/j.dadm…
@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition Day 3 - Statin Adverse Effects:
Dose/Time Dependent Development of T2D
@lowcarbGP @DaveKeto @DavidPerlmutter

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Day 4: Statin Adverse Effects
Women are more susceptible to develop statin-induced T2D than Men
e100 DIABETES CARE, VOLUME 36, JULY 2013

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Day 5 - Statin Adverse Effects
TD isn't aware of muscle wasting with statins, so this week is devoted to muscle adverse effects - Please educate him
Creatine phosphokinase levels used to determine statin-induced muscle damage, but this paper shows damage occurs w/o ⬆️CP

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Day 6 - Statin Adverse Effects - Muscle Pain Week:

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Day 7 - Statin Adverse Effects - Muscle Pain Week:

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Happy Thanksgiving! Watch those carbs - especially for those on statins -
Day 8 Statins = T2D hazard zone
@lowcarbGP
Diabetes Metab Res Rev. 2019;35":e3189.
doi.org/10.1002/dmrr.3…

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Adverse Effects Day 9 - Excessively tired after Thanksgiving? could be your statin sapping your energy:
"unfavorable statin effects on energy
& exertional fatigue. Effects were seen in a generally
healthy sample given modest statin doses"
doi:10.1001 /archinternmed.2012.2171

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Adverse Statin Effects Day 10: ⬇️Insulin sensitivity
"Patients who started statin therapy ...
experienced a greater decrease in insulin sensitivity &
metabolic control deterioration compared with statin-free group"
Black line = statin, grey = no statin y axis = HR

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Adverse Statin Effects Day 11: Muscle pain dev into an ALS-like syndrome
Dr Golomb, UC San Diego
"ALS first emerged, or accelerated, with statin
dose increase or rechallenge. ... subjects noted
... abatement of symptoms ... with statin discontinuation"
doi.org/10.2165/000020…

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter Adverse Statin Effects Day 12:
Heart failure epidemic with ⬆️statin use.
⬆️HF survival w/ statin withdrawal
"Statin-associated cardiomyopathy responds to statin withdrawal and administration of coenzyme q10"
doi.org/10.7812/TPP/18…
@Alabdulgaderaa @DietHeartNews @holmanm

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter @Alabdulgaderaa @DietHeartNews @holmanm Adverse Statin Effects Day 13:
High Rate of ALS Reported to the FDA by Statin Users
Drug Safety (2018) 41:403–413
doi.org/10.1007/s40264…

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter @Alabdulgaderaa @DietHeartNews @holmanm Adverse Statin Effects Day 14:
"Conclusions: Use of high potency statins is associated with an increased rate of diagnosis for acute kidney injury in hospital admissions compared with low potency statins."
BMJ 2013;346:f880 doi: 10.1136/bmj.f880

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter @Alabdulgaderaa @DietHeartNews @holmanm Adverse Statin Effects Day 15:
"Statins are associated with increased risk of SSTIs (skin and soft tissue infections) ... We believe that clinicians should be aware of the association between statins and SSTIs"
DOI: 10.1111/bcp.14077

@FatEmperor @ProfTimNoakes @FructoseNo @DrAseemMalhotra @KenDBerryMD @TuitNutrition @lowcarbGP @DaveKeto @DavidPerlmutter @Alabdulgaderaa @DietHeartNews @holmanm My tweet string began with TD reporting no adverse effects of statins on cognition, My response on Day 1, which initiated this string, is missing. So I've added it here. All are welcome to share and ask TD why he doesn't participate in a discussion on statin adverse effects.