Discover and read the best of Twitter Threads about #cytokine

Most recents (5)

offering comprehensive #cytokine profiling (including RANTES levels), to help Drs understand the pathogenesis of Childhood Inflammatory Disease Related to #COVID19 #Leronlimab pdf.reuters.com/htmlnews/htmln…
Recent reports in parts of the U.S. and Europe suggest a rare and potentially fatal inflammatory disease linked to #coronavirus is afflicting a small number of children. #Leronlimab may be able to help calm #CytokineStorm
Condition resembles a rare childhood illness called #KawasakiDisease, which has similar signs and symptoms and can lead to enlargement of blood vessels that in severe forms may cause heart damage. #Leronlimab has shown to help calm #CytokineStorm and maybe good #treatment
Read 6 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets
#Remdesivir begins distribution in the #USA today via #EUA.

I thought would write down some practical #tips based on my #qualitative anecdotal experience after personally treating close to 200 patients with #COVID19.

For quantitative results, wait for the papers¬—thread
“this juice works, doc!” When you hear similar expressions 1-2 days after starting #remdesivir multiple times, you start to wonder. Don't recall a similar proportion of patients smile after feeling so sick 1-2 days earlier with #COVID19. x/n? Wait for the papers.
Like #treatment for any severe infectious disease (meningitis, Gram-negative bacteremia, influenza pneumonia, etc), earlier is always better. #COVID19 is no different. #Remdesivir stops #SARS-CoV2 replication, but won’t heal the lung injury.
Read 13 tweets
1/
#Obesity and #COVIDー19 have been in the headlines recently.

The link between the two is now undeniable.

Let’s take a look at WHY they are so tightly linked molecularly, physiologically, and anatomically in this #tweetorial.

#medthread #medtwitter

nytimes.com/2020/04/16/hea…
2/
We learned quite a bit about obesity and viral infection in 2009 during the #H1N1 epidemic. Obesity led to:

🔼risk of ICU admission
🔼viral shedding
🔼recovery times

But WHY?

ncbi.nlm.nih.gov/pmc/articles/P…
The story is complex, but inflammation plays a critical role.

Individuals with obesity are in a state of chronic low-grade inflammation as evidenced by altered levels of several cytokines such as TNFα, IL-6, and CRP.

ncbi.nlm.nih.gov/pubmed/22429824
Read 11 tweets
Starting a series on clinical Pearls I am gathering in #COVID19 patients based on experiences of many experts

Will add as we go along

Feel free to add your own observations/experiences

#covidclinicalpearls /1
Anosmia is likely the most specific #COVID19 related symptom
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
Around 90% of patients have fever.
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients

#covidclinicalpearls /3
Read 66 tweets

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