Discover and read the best of Twitter Threads about #t1d

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ALL ABOUT INSULIN: A THREAD
In 1921 Canadian Frederick Banting discovered “insulin”. It was tested first on diabetic dogs for that year. In 1922, it was purified and then used on dying children with type 1 diabetes. He sold the patent for $1 saying “insulin doesn’t belong to me, it belongs to the world”
Before the 1920s, children diagnosed with type 1 diabetes were basically told they had a few days or weeks left to live. For most of human history, anyone unfortunate enough to suffer from Type 1 diabetes would almost certainly die.
Read 21 tweets
After 36 years of type 1 diabetes (#T1D), the last year or 2 have been tougher than usual. Patterns shifting bit by bit, my old tricks not working so well anymore, hypo unawareness getting worse, lows coming out of nowhere, increasing fear of travel, fear of driving, less energy.
I started using versions of this slide at the start of my talks earlier this year. The unpredictability had started to bleed into my talks. (“Hey, this isn’t a pager, it’s a medical device. It might beep. I might need to check it. I’m not being rude. I can’t turn it off. Sorry.”) A slide with photos: a small girl colouring, a test tube urine testing book, a woman with a sensor in her arm, a meme with
I developed a new side effect of low blood sugar: deep despair that lingers for hours. It’s about as fun as it sounds, sweeping in for a leisurely stay on the heels of brutally disruptive out-of-nowhere lows. I already hated hypos enough.
Read 25 tweets
Summary of results from iDCL trial of Tandem/Dexcom hybrid-closed loop system at #ADA2019
Included: 14 yrs and older, T1D > 1 yr
Minimal entry restrictions
170 subjects enrolled: Closed loop (112 ppl), sensor-augmented pump (56 ppl) #diabetes #t1d #closedloop
Subject characteristics: 33 years old; A1c 7.4% baseline; 20-25% MDI; 70% current CGM user;
Median diabetes duration 15 yrs
Outcomes:
100% of people completed study
Time in range increased 11% (to 71% in closed loop group); A1c decreased -0.33%; Mean glucose decreased 13 mg/dL;
Participants used CGM 97% time; 92% time with closed loop active.
Read 4 tweets
The 1st drug (a monoclonal antibody) to delay onset of autoimmune #diabetes in high risk individuals (by ~ 2 years)
nejm.org/doi/full/10.10… #ADA2019 @NEJM #T1D @T1D_Trialnet
"The results of this trial are striking, with several caveats."
A long road that has taken 40 years. And still just a start to prevention.
Exciting, nonetheless.
nejm.org/doi/full/10.10… @NEJM editorial #ADA2019
by @clifford_rosen and @ingelfinger
'Herold procrastinated when it came time to analyze the data. “I kept pushing it off,” he says, because he worried about failure.'
Some interesting backstory to this major milestone trial
@sciencemagazine sciencemag.org/news/2019/06/m… by @jcouzin
Read 3 tweets
Cetoacidosis Diabética #DKA #CAD #AMTIP

Bases de la Enfermedad y análisis del Diagráma de Flujo @NICEcomms Diciembre 2018

Abro hilo, iniciamos👨‍💻y abierto comentadios

@MarianaPediatra @FOAMexico @CantillMauricio @Javier_Prego @erikablasco @pediatraweb10 @RobustosMD @carsolbal
Para ti #urgenciologos, #pediatras e #intensivistas

Daremos un repaso discreto de CAD y analizaremos el texto de la NICE Pathway

Comentaremos con relación a las guías @ispad_org, una de las más utilizadas a nivel mundial

En pocas palabras, el diagrama con relevante información
#CAD puede presentarse en #T1D y #T2Diabetes. Debido a obesidad, han aumentado los casos en esta última, presentándose también como debút.

#T1D es resultado de destrucción autoinmune progresiva de células beta. Ocurre a una tasa de 6-8%/año en aquellos con Dx establecido.
Read 39 tweets
I was recently asked 'how is the non-communicable disease #NCDs agenda going to ever get the same sort of money #HIVs did to achieve change?' I thought it was a very interesting question. Here are my thoughts, feel free to add/chime in/disagree #globalhealth #insulin4all 1/12
Everyone is trying to duplicate the #HIV movement without *actually* duplicating it. The sanitized history is that Bill Gates +Clinton + Bono got together and made HIV meds cheap. The real history is completely different cc @jamie_love @gregggonsalves theguardian.com/society/2016/j… 2/12
It was *patient* activism that turned the tide. It was groups like @actupny in the US or Treatment Action Campaign in South Africa, groups that could shut down the FDA or raise 10,000 people to march in Cape Town. It was not celebrity or academics 3/12
Read 12 tweets
1,400 Canadians have died and 14,000 have been injured by faulty and unproven medical devices since 2008, by @jesse_mclean @TheCribby thestar.com/news/investiga… via @ICIJorg @torontostar #ImplantFiles
CBC takes you inside Health Canada's medical device records newsinteractives.cbc.ca/medical-device… via @cbchealth @MEDEC_Canada #ImplantFiles
'We're guinea pigs': Canada's oversight process for implanted medical devices stuns suffering patients, by @valerie_ouellet @VikCBC @mckiedavid cbc.ca/news/health/im… via @cbchealth #ImplantFiles
Read 24 tweets
Up first @jbwittmer on the DIY revolution in #T1D
CGM is great, but you need more
DIY diabetes is not about wanting to tinker, but needing to have the features #OpenAPS
Read 21 tweets
I want to share something cool that happened today. It's a bit of a story, though so bear with me. It starts with me being diabetic. I'm Type 1, and was diagnosed in 2000 when I was 30 years old.
2/ I've been insulin dependent for the last 18 years. I have to manually test my blood sugar, and administer insulin through a pump. About 2 years ago, my friend @kamens introduced me to a cool solution that creates a closed loop.
3/ A closed loop is a system that acts like an artificial pancreas by using open source and home built hardware to bridge the gap left by FDA approved medical technology.
Read 15 tweets

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