Precise and efficient genome editing with just a virus? Claim that AAV virus can rewrite genes *no CRISPR needed* was published in PNAS. Huge if true!
(THREAD)
(THREAD)
Last Aug, we covered questions swirling round this technology, and a startup commercializing it, Homology Medicines.
A totally new way to efficiently edit genome would be a huge deal. But some people just didn't believe it. technologyreview.com/s/608749/in-a-…
A totally new way to efficiently edit genome would be a huge deal. But some people just didn't believe it. technologyreview.com/s/608749/in-a-…
I didn't realize that Homology actually went public in March. About $275 million raised so far, in toto, I think. Big money. Here is the S-1. sec.gov/Archives/edgar…
Take a look at the S-1. Unusual that scientific basis of IPO stock offering was an oral presentation at a conference! 
But now the paper is out. It's from the lab of the tech's originator, Saswati Chatterjee, and was pubbed recently in PNAS . Not a first choice journal for dogma busting result. h/t @pdhsu for flagging it. pnas.org/content/early/…
I wonder what science community will have to say about the paper. It's been out for a couple of weeks and things are real quiet. (n.b. new AAVs are real valuable for gene therapy, even w/o editing capability) /END
See if you can get the vector
