Thread by @mariliacout

1/ As we spoke about depression and esketamine yesterday, I will review a few nutritional supplements that can be helpful for patients. As a disclaimer, I'd like to say that my long monitoring of research and clinical observation from physicians .... @BulkSupps

2/ ... suggests that apart from acute interventions such as the one I reviewed yesterday or even potent anti-psychotics during a crisis, there is no single treatment that provides any highly satisfactory condition to the mood disorder patient.

3/ Any effective treatment is a combination of strategies that include (or not) some anti-depressant medication, a physical activity regimen, adjustments in diet and bioactive xenobiotics found as nutritional supplements. @BulkSupps

4/ One of the oldest dietary supplement interventions that seemed to have antidepressant activity are the omega-3 polyunsaturated fatty acids (PUFA) found in fish oil. @BulkSupps
bulksupplements.com/fish-oil-softg…

5/ Their role in bipolar disorder has been suggested over 20 years ago through epidemiological studies on populations that consumed higher amounts of PUFA. A recent meta-analysis has shown that indeed it does.
ncbi.nlm.nih.gov/pmc/articles/P…

6/ Although the mechanisms of action are not entirely clear, the Clinical neuroimaging studies suggest that low n-3 PUFA biostatus is associated with abnormalities in cortical structure and function also observed in mood disorders. @BulkSupps
ncbi.nlm.nih.gov/pmc/articles/P…

7/ In major depression, it is possible that the DHA concentration and EPA conversion to DHA are critical for the clinical response. PUFA supplementation is, however, effective in the short term. @BulkSupps
ncbi.nlm.nih.gov/pmc/articles/P….

8/ Epidemiological data about the depression preventive effect of fish oil consumption is compelling.
ncbi.nlm.nih.gov/pmc/articles/P…

9/ Confirming, today, what prompted this line of research decades ago.
ncbi.nlm.nih.gov/pubmed/30238628

10/ The average American diet is dangerously poor on PUFA and high on ALA, which has shown no effect on mood disorder prevention or treatment. @BulkSupps
academic.oup.com/ajcn/article/7…

11/ Although the American diet is particularly poor and/or nutritionally inappropriate, PUFA consumption is lower than recommended (for any of its biological activities) worldwide.
@BulkSupps
karger.com/Article/FullTe…

12/ Dietary supplementation serves precisely this role: when certain substances that are critical for health are absent from the diet, isolated preparations can correct the imbalance.
@BulkSupps

@threadreaderapp unroll

13/ I forgot: if you feel inclined to try fish oil, my partner @BulkSupps is the best choice, with a good EPA/DHA ratio and high purity. For discount, use code Marilia5 at shrsl.com/18low-155a-cwy6