Thread by @EricTopol

"Digital Orthodoxy," aka Deep Phenotyping or High-dimensional human data, is a great research tool w/ many proven advances, but has NO commercial/clinical validation and may be harmful
thelancet.com/journals/lance…
Our latest @TheLancet Digital Medicine essay
@EvanMuse @ScrippsRTI

@TheLancet @EvanMuse @ScrippsRTI The multi-modal testing may someday be validated to benefit, but until that time we raise concerns about the practice, ethics and safety for companies to be charging individuals for such data accumulation.

@TheLancet @EvanMuse @ScrippsRTI In @TheLancet essay we briefly touched on advances that deep phenotyping of people has made in biomedical research. I'm going to briefly review 5
1. Pre-diabetes-> #diabetes
2. Individualized diet
3. Colon #cancer+ microbiome
4. Gut #metagenomics sequence Δ
5. Tumor microbiome

@TheLancet @EvanMuse @ScrippsRTI 1. Tens of millions of Americans are thought to be at risk of #diabetes sciencemag.org/news/2019/03/w…
A longitudinal, multi-modal approach helped predict
who nature.com/articles/s4158… @Nature #openaccess

@TheLancet @EvanMuse @ScrippsRTI @nature 2. A multi-omic strategy w/ machine learning analytics was a seminal contribution for predicting individualized glycemic response to food (work from @WeizmannScience) @CellPressNews cell.com/abstract/S0092… and recently extended to triglycerides

@TheLancet @EvanMuse @ScrippsRTI @nature @WeizmannScience @CellPressNews 3. Deep phenotyping of patients with colon #cancer revealed stage-specific changes in the gut #microbiome
nature.com/articles/s4159… @NatureMedicine

@TheLancet @EvanMuse @ScrippsRTI @nature @WeizmannScience @CellPressNews @NatureMedicine 4. Many phenotypic features were shown not just to be related to the gut #microbiome, but to specific sequence variants of bacteria via #metagenomics nature.com/articles/s4158… @nature
(work also from @WeizmannScience, @segal_eran and colleagues)

@TheLancet @EvanMuse @ScrippsRTI @nature @WeizmannScience @CellPressNews @NatureMedicine @segal_eran 5. And going deep into #cancer tissue, the tumor #microbiome (yes, you read that correctly) was shown to be important for immune system response and prognosis in patients with pancreatic cancer @CellPressNews #openaccess cell.com/cell/fulltext/…