Thread by @edgarvlermamd

Preparing for a 45-minute lecture on Review of Nephrology Literature 2019
📌 Please recommend noteworthy publications
🔲 Fluids & Electrolytes, Acid-Base
🔲 CKD
🔲 Hypertension
🔲 Glomerular Diseases
🔲 Cystic Disorders
🔲 Kidney Transplant
🔲 AKI
#Nephpearls #AskRenal

CREDENCE: Canagliflozin reduces the risk of kidney failure or death due to CV or kidney disease by 30% compared to current standard of care ca. 2019 from @NEJM
#VisualAbstract by @brendonneuen
#Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…

Randomized Controlled Trial of Long-Term Safety and Efficacy of Veverimer for Treatment of Metabolic Acidosis
#Nephpearls

After achieving normokalemia, individualized once daily sodium zirconium cyclosilicate (SZC) was associated with maintenance of normokalemia without substantial RAAS inhibitor changes for </= 12 months #Nephpearls
👉🏼 cjasn.asnjournals.org/content/clinja…

MENTOR: Rituximab (vs Cyclosporine) for Membranous GN ca. 2019 from @NEJM
📌 Non-inferior in inducing complete/ partial remission of proteinuria at 12 months #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…

Roxadustat for Anemia in CKD from @NEJM #Nephpearls
📺 nejm.org/do/10.1056/NEJ…

Effects of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function and Damage in Type 2 Diabetes from @JAMA_current @deboerih #Nephpearls
👉🏼 jamanetwork.com/journals/jama/…

KALM-1: Efficacy and Safety of Difelikefalin in Patients Undergoing Hemodialysis with Pruritus: Results from a Phase 3 Randomized, Controlled Study from @sfishbane @NEJM
#VisualAbstract by @kidney_boy
#Nephpearls
👉🏼 nejm.org/doi/full/10.10…

Pruritus and Patient Reported Outcomes in Non-Dialysis CKD ca. 2019 from @CJASN
#VisualAbstract by @kidney_boy
#Nephpearls
👉🏼 cjasn.asnjournals.org/content/14/5/6…

In the HARMONIZE Open Label Extension, most patients maintained mean serum K+ within the normokalemic range for ≤11 months during ongoing SZC treatment ca. 2019 from @AmJNephrol
#VisualAbstract by @kidney_boy
#Nephpearls
👉🏼 karger.com/Article/Pdf/50…

Long-Term Efficacy and Safety of Molidustat for Anemia in Chronic Kidney Disease: DIALOGUE Extension Studies ca. 2019 from @AmJNephrol #Nephpearls
👉🏼 karger.com/Article/FullTe…

The proportional effects of canagliflozin on renal & CV outcomes are mostly consistent across patients w/ different levels of albuminuria, but absolute benefits are greatest among those w/ severely ⬆️ albuminuria
#Nephpearls
👉🏼 jasn.asnjournals.org/content/30/11/…

Sodium zirconium cyclosilicate is an effective and well-tolerated treatment for predialysis hyperkalemia in patients with ESKD undergoing adequate hemodialysis ca. 2019 from @JASN_News @sfishbane #Nephpearls
👉🏼 jasn.asnjournals.org/content/jnephr…

Rate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients ca. 2019 from @scoca1 @CJASN #Nephpearls
#VisualAbstract by @whatsthegfr
👉🏼 cjasn.asnjournals.org/content/14/5/6…

SONAR: Atrasentan & renal events in patients w/ type 2 diabetes and CKD: a double-blind, randomised, placebo-controlled trial ca. 2019 from @TheLancet #Nephpearls
#VisualAbstract by @NephroGuy
👉🏼 thelancet.com/journals/lance…

UBI: In persons with CKD 3–5 without advanced stages of chronic heart failure, treatment of metabolic acidosis with sodium bicarbonate is safe and improves kidney and patient survival ca. 2019 #Nephpearls
👉🏼 link.springer.com/article/10.100…

PIVOTAL: Among patients undergoing hemodialysis, a high-dose IV iron regimen administered proactively was superior to a low-dose regimen administered reactively and resulted in lower doses of ESA being administered from @NEJM #Nephpearls
👉🏼 nejm.org/doi/full/10.10…

AMBER: Patiromer to Enable Spironolactone Use in the Treatment of Patients with Resistant Hypertension and CKD from @TheLancet
#VisualAbstract by @werner02 #Nephpearls
👉🏼 thelancet.com/journals/lance…