Thread by @SapnaKmd

The moment we have been waiting for!! @jerjohzimm #sepsis @PedCritCareMed @ESICM #ccc49 (thread)

#sepsis #PedsICU

bit.ly/3bJIr1k

.@PierreTissieres is up first introducing the process & rationale #CCC49 #PedsICU #Sepsis

@TexKissoon tells us “Why Now”? #ccc49 #PedsICU #sepsis

Burden is highest on #children, and deaths occur early in the course

@TexKissoon tells us all the #pedsicu people behind the guidelines and summary #sepsis #ccc49

.@waleedalhazzani describes the #methodology #ccc49 #sepsis #PedsICU

New term: GOBSAT= Good old boys sitting around a table 😊

@waleedalhazzani : Form the Question. Summarize the evidence. Determine the quality of evidence. #ccc49 #sepsis #PedsICU

.@waleedalhazzani - More on summarizing quality of evidence via GRADE approach. Interesting challenge is whether to use indirect and/or direct evidence.

Now we have to move to recommendation. #CCC49 #PedsICU #sepsis

.@waleedalhazzani helps us break down GRADE- what does it mean? #CCC49 #sepsis #PedsICU

Strong vs Weak recommendation language

Scott Weiss is next! Too much to summarize, all in the slides! #PedsICU #sepsis #ccc49

Part 1: Antibiotics in #pediatric #sepsis #ccc49 #pedsicu via Weiss

@PierreTissieres breaks down hemodynamic #resuscitation #ccc49 #pedsicu #sepsis

Summary from @PierreTissieres #ccc49 #PedsICU #sepsis

Weiss is back- now on #esicmnutrition in #sepsis #pedsicu #ccc49

Feed the children. Gastrically if possible. Suggest against use of vitamins & minerals in slide- but note weak rec

Weiss summarizes mechanical ventilation & #nutrition guidelines #ccc49 #pedsicu #sepsis #respiratory

Now @PierreTissieres is back on adjunct therapies #ccc49 #PedsICU #sepsis

Steroids, insulin, calcium, blood guidance

Plasma exchange, RRT, #ECMO, guidance in #sepsis via @PierreTissieres #ccc49 #PedsICU

Key Summary slide on adjunctive therapies via @PierreTissieres #ccc49 #sepsis #PedsICU

@TexKissoon talks about adapting the guidelines to resources. So many factors to consider. Practical applications are critical. #LMIC #CCC49 #PedsICU #sepsis

Key #FOAMed paper in press in @TheLancet bit.ly/2uJ0m7O

Hear the key factors in adapting to resources from @TexKissoon #ccc49 #PedsICU #sepsis

The algorithm & bundle is up next! @TexKissoon - be sure to check out the main document for all details! bit.ly/2HxTMUk #ccc49 #PedsICU #sepsis

Answering @mommimaya twitter question #PedsICU #Ccc49 #sepsis

What is a bedside clinician supposed to do with the “Hydrocortisone may provide benefit or harm guidance?”