NEW: Clinical course and outcomes of critically ill patients with #SARSCoV2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study thelancet.com/lancet/article…
#COVID19 #Coronavirus
#COVID19 #Coronavirus
Of 710 patients with #SARSCoV2 pneumonia, 52 critically ill adult patients were included. The mean age of the 52 patients was 59·7 (SD 13·3) years, 35 (67%) were men, 21 (40%) had chronic illness, 51 (98%) had fever
32 (61·5%) patients had died at 28 days, and the median duration from admission to the intensive care unit (ICU) to death was 7 (IQR 3–11) days for non-survivors
Compared with survivors, non-survivors were older (64·6 years [11·2] vs 51·9 years [12·9]), more likely to develop #ARDS (26 [81%] patients vs 9 [45%] patients), and more likely to receive mechanical ventilation (30 [94%] patients vs 7 [35%] patients), invasive or non-invasive
Most patients had organ function damage: 35 (67%) with #ARDS, 15 (29%) with AKI, 12 (23%) with cardiac injury, 15 (29%) with liver dysfunction, and one (2%) with pneumothorax. 37 (71%) patients required mechanical ventilation. Hospital-acquired infection occurred in 7 (13·5%)
#Lymphocytopenia occurred in more than 80% of critically ill patients in this cohort and is a prominent feature of critically ill patients with #SARSCoV2 infection
Limitations of the study include: small sample of patients, missing specific information from the ICU, such as mechanical ventilation settings, and retrospective study design
