1/ This study is extremely fascinating, but also not too surprising. Lipids/Lps drop during infection of CV.
#covid19/#coronavirus
#LDL #cholesterol
#immuneSystem
Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China
papers.ssrn.com/sol3/papers.cf…
#covid19/#coronavirus
#LDL #cholesterol
#immuneSystem
Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China
papers.ssrn.com/sol3/papers.cf…
2/ "Findings The absolute value of white blood cells, neutrophils and lymphocytes were
lower than healthy controls ( P ＜0.05), more significantly, the patients had sharply
decreased total cholesterol (TC), HDL-cholesterol and LDL-cholesterol levels..."
lower than healthy controls ( P ＜0.05), more significantly, the patients had sharply
decreased total cholesterol (TC), HDL-cholesterol and LDL-cholesterol levels..."
3/ Results
1. Serum lipid levels generally decreased at the initial stage of infection
2. More significant decline in cholesterol level in primary cases
3. The changes of serum lipid are independent of gender and age
4. The serum lipid changes in a critically infection case
1. Serum lipid levels generally decreased at the initial stage of infection
2. More significant decline in cholesterol level in primary cases
3. The changes of serum lipid are independent of gender and age
4. The serum lipid changes in a critically infection case
4/ "In view of the immunomodulatory effects of HDL cholesterol, we speculate that serum HDL-cholesterol was involved int the regulation of immune cells during COVID-19 infection, which might lead to the significantly dropped HDL-cholesterol level in the patients."
5/ "However, it still remains to be verified by further studies to elucidate whether HDL and LDL is oxidized or not, whether they active or still negatively regulate immune cells during COVID-19 infection."
6/ (A spec pt) "They all showed that cholesterol level continued to drop during the first few days of patient's hospitalization, then gradually rose until she was discharged. Furthermore, on the 14th day after her discharge, the serum lipid returns to higher level."
7/ "In a study in 2017 24, serum metabolomic analyses was performed in 25 recovered SARA patients 12 years after infection. Their data showed that the significantly higher level of TG and very low-density lipoprotein (VLDL) cholesterol than healthy controls." (yep)
8/ "Taken together, cholesterol play an essential role in not only virial replication, internalization, but also immune activation. Significant declined the serum cholesterol level of patients provide us important information for us to understand the COVID-19 infection..."
