Thread by @KrutikaKuppalli

Ppl ask, why not try #Hydroxychlorquine and #Azithromycin for #SARSCov2 #COVID19. Here is some important info to know about the study sciencedirect.com/science/articl…

1. 20 HCQ pts (200 mg TID) & 16 controls with SARSCoV2
2. Pts w/ URTI, LRTI, or asx
3. 6 HCQ pts received Azithro x 5 d

4. Pts received Azithro to prevent bacterial superinfxn
5. At day 6 post-inclusion 70% of HCQ pts were virologically cured vs 12.5% in control
6. At day 6 100% (6 pts ) with HCQ+Azithro were virologically cured vs 57.1% of HCQ only (14 pts) vs 12.5% in control (16 pts)

Although this data is potentially promising there are a few things to consider
1. This study is not powered for efficacy
2. Small sample size
3. No long term follow-up (although virologically cured unknown if it returned)
4. Unclear info on pt co-morbidities who received drugs

5. #Azithromycin is a antibiotic that binds to the ribosome of a bacteria so it doesn’t make sense it works. It may have anti-inflammatory effect or none at all, but we do not know.
6. #HCQ is enters RBCs. The mechanism of action in viruses is not understood.

7. Before anyone is put on #HCQ or #CQ they need to be tested for G6PD deficiency otherwise can have serious adverse effects
8. Azithromyin can -> inc risk of C.Diff, VTach, and death
9. HCQ/CQ can -->seizures, vision loss, and abnormal heart rhythm.

NOT BENIGN MEDS TO TAKE