Chloroquine is substantially excreted by the kidneys and the risk of renal toxicity is greater in elderly patients as well as those with impaired renal function. Various drug interactions are possible: chloroquine may enhance the effect of insulin and other antidiabetic drugs.
Chloroquine poisoning include:
Collapse and cardiovascular failure, impaired cardiac output or vasodilation which may result in organ failure. Cardiac features may be enhanced by other drugs such as beta blockers, calcium- and sodium channel blockers.
Collapse and cardiovascular failure, impaired cardiac output or vasodilation which may result in organ failure. Cardiac features may be enhanced by other drugs such as beta blockers, calcium- and sodium channel blockers.
Respiratory: pulmonary toxicity; aspiration pneumonia, acute lung injury and respiratory distress syndrome (ARDS) with alveolar hemorrhage in severe cases.
Gastrointestinal: nausea and vomiting are frequent. Early vomiting may reduce GI chloroquine absorption, but may result in aspiration pneumonia.
Metabolic: metabolic acidosis, hypokalaemia, hyperlactataemia are common.
Metabolic: metabolic acidosis, hypokalaemia, hyperlactataemia are common.
The toxicology profile of Chloroquine is in no way indicative of the possible efficacy nor safety in the treatment of respiratory illnesses such as COVID-19. On the contrary, there are clear red flags that indicate the opposite.
@threadreaderapp unroll
According to the Oxford desk reference on toxicology:
Chloroquine poisoning may be life threatening. In adults doses over 5 g are likely to be fatal, but death may occur with lower doses, too.
The drug is concentrated in the red cells and metabolized in the liver.
Chloroquine poisoning may be life threatening. In adults doses over 5 g are likely to be fatal, but death may occur with lower doses, too.
The drug is concentrated in the red cells and metabolized in the liver.
