Do we yet understand immunologically speaking, what is going on in kids versus adults that means the young, (generalizing here) are not impacted as hard by SARS-CoV-2 as are their elders?
Because it looks to me very much like we're watching in real time, the emergence of a common cold virus. Once all the kids are immune, we'll then have an endemic virus cycle forever in which adults don't get as sick because immunity. As we see with other respiratory viruses.
Why it is that kids don't get as sick from endemic respiratory viruses generally speaking (sure there arvlotvsif severe infections)? Maternal immunity protects early on right? But is what we're seeing in kids & with SARS-CoV-2 suggesting there's more to it than that ?
And is there a role for past HCoV immunity in making COVID-19 worse for adults, better for kids (more recently first infected pros?), or is it something about adults that creates more of an immunological over-reaction (imprinting, ADE?) to a novel CoV than kids do?
