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SARS-CoV-2: A Storm is Raging: Our Preview/Perspective for Chen on JCI: by day 8 after infection, it's cytokine storm and CD4/CD8 decrease that causes respiratory failure, not viral load. Agree w/ Stanley Perlman & @VirusesImmunity
shorturl.at/frwxZ shorturl.at/dJMN5
This is the first peer-reviewed study characterizing cytokine profiles, CD4 count and T cell function in SARS-CoV-2-infected individuals. Cytokine storm correlates with disease severity.
Thanks to @jclinicalinvest @soupvector for this opportunity to contribute our thoughts, put together by our oustanding premed Savannah Pedersen.
Check out these papers, in which single-cell profiling of immune cells and cytokine storm has been done:
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
Here is the full link in case the above doesn't work:
Preview: jci.org/articles/view/…
Original article: jci.org/articles/view/…
Also check the mechanisms of cytokine storms by Stanley Perlman for the old SARS-CoV:
cell.com/cell-host-micr…
@FilippoVeglia81 @VirusesImmunity We don't know about how asymptomatic patients respond to SARS-CoV-2 yet. Immunologic study on immunologic responses of asymptomatic patients responded is urgently needed to direct human response to protective immunity.
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Julio Rodríguez, PhD
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"La presencia de un gran reservorio de virus similares al #SARS-CoV en los murciélagos de herradura, junto con la cultura de comer mamíferos exóticos del sur de China, es una bomba de relojería."
Octubre de 2007. El resto es historia 👇
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Jonathan Rothberg 🧬🧪
@JMRothberg
Reporting progress on #coronavirus Home Test from our teams internal email: Just wanted to give a brief update from the #molbio team as we build momentum towards delivering an at-home, user-friendly, rapid #COVID19 test...We are actually detecting Covid19 #RNA in solution now! 1/
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Dr. Ilin Gilberto dlT
@IlindelatorreMD
#SARS-CoV-2

¿Cuál es el período de incubación?
• 2 a 14 días; mediana 4-5 días.

¿Cómo se transmite COVID-19?
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¿Si estoy infectado, ¿puedo volver a infectarme?
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¿Cuál es la tasa de letalidad de COVID-19?
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Edwin Silva Monsalve
@edwinsilmon
@CienciaAbiertaL Compartimos una sinopsis de esta entrega de NEJM llena de preguntas muy inquietantes. @NEJM Un nuevo coronavirus emergente en China: preguntas clave para la evaluación del impacto.
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Angelina Nic
@AngelinaNic6
Concerning the CARONAVIRUS -

Someone got Busy , In The Lab .... If you don t know The virus , How can You Give It A Name , No Cure .... Brilliant timing ! Do you Want The Antidote of This Bug ?

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The Menachery Lab
@TheMenacheryLab
Been doing my best to avoid twittering over the break, but a rumored return of #SARS in 2020 caused me to dive into twitter and google translate for more information. Here are some random facts, thoughts, and speculation on what may or may not be happening with in Wuhan.
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