Well, I got 2 messages before 9am from friends telling me they have #COVID19 in their households. And in the 12 mins since, I’ve just heard about 4 more. So Merry Exponential Growth #Omicron #Christmas. 🌲 😫

A quick 🧵 on what to do if that’s you since I’m typing it anyway.
1/ The first thing to say is that if someone has #COVID19 symptoms (#Omicron most common: nasal congestion/runny nose, scratchy sore throat, fever, & aches), you have to assume they have it. You may not have a test (urgent cares are still open & do) or they may still be neg.
2/ You, as the person exposed to the one with symptoms, have to assume that you both do & don’t have #Omicron too. Wait, what? 🤔

I mean: assume you could infect others now & take care to avoid exposing them, BUT don’t assume it’s too late for you to avoid getting it.
3/ Especially in households with #vaccinated (& #boosted) family members, I have seen people manage to limit #Omicron to the first person who was infected. This #CovidVariant is incredibly contagious, but It CAN be done. Don’t give up on the idea!
4/ If you have N95/KN95/KF94 masks, get in them immediately. If you have only 1, put the sick person in it for source control. If you have >1 but not enough for all put the sick one & the highest risk (older, #immunocompromised) people in them. Then get outside, & leave🚪open.
5/ Fresh air is a friend & shared air is an enemy. The more you can ventilate your 🏠, now & until this is over, the better. You want the concentration of #omicron in air as low as possible. This ⬇️ odds of infection & may make you less sick if you do get infected.
6/ Plan to bundle up if you’re in a 🥶 climate, because you’re going to need to leave 🪟 & 🚪 open enough for air exchange, esp for next 5d or so, & a cross draft. If you have a fresh HVAC filter, change it. If a hardware place is open, get a MERV13 HVAC filter. (Amazon has too.)
7/ Run the fan on your thermostat on high. Filter that #Omicron 🦠!

If you need supplies of any kind, please do curbside pickup or same-day delivery or drive-thru. No one exposed should be indoors in public, & def not the one with symptoms, to prevent further spread.
8/ If you don’t have any N95/KN95/KN94 masks, please see if a nearby friend or neighbor has unused ones you can have & order them replacements. The nonprofit @projectn95 (projectn95.org) is a great place to get them. Your backup plan for right now is a surgical 😷.
9/ A surgical 😷 (ASTM level 3, 3-ply is best) has good filtration but usually not good fit. There are often gaps. Knot ear loops where they join the 😷 & then tuck to improve the mask fit. Here’s a short video demo: . Put a cloth 😷 over the surg 😷.
10/ Now it’s time to create the space where the infected person or people will isolate for 10d to let #Omicron run its course. This prior 🧵 of mine covers what is helpful to have in there & other things to consider.
11/ This whole scenario assumes that things are going ok with the person who has #Omicron. How do you know if they are ok? As I mentioned before, if you have a pulse oximeter (O2 sat monitor)—the thing drs put on your fingertip to measure O2–use it. See guide in 📸 .
12/ If you don’t have a pulse oximeter, many pharmacies carry them. They are over the counter. Ask the pharmacist if you don’t see them. You can order them online from many places too. Get one highly rated by many people. They need not be expensive. $15 gets a very good one.
13/ Some of your devices (smart watches, fitness trackers) can detect ❤️ rate (60-100 normal for adults) & less reliably O2 levels. If you have them & they read low O2 levels, def do call a dr or seek care. Video calls on 📱 or 💻 are helpful to check on the sick as well.
14/ If the person w/ #Omicron is high-risk (especially #immunocompromised, organ or bone marrow transplant, active #cancer, #pregnant, #diabetes, older, etc), they should contact a dr even if they seem ok. There are outpatient treatments that sig ⬇️ risk of being hospitalized.
15/ These include monoclonal antibodies (some brands no longer work vs #Omicron, but 1 called sotrovimab remains effective). It is given IV as a single dose. There are also two types of pills taken for 5d at home. All are in short supply at the moment. google.com/amp/s/abcnews.….
16/ All of these things to treat outpatients w/ #Omicron, the monoclonal antibody sotrovimab, as well as the pills (Paxlovid: google.com/amp/s/www.nyti…) & (molnupiravir: google.com/amp/s/www.nyti…) are new, so they are being reserved for higher-risk folks while supply increases.
17/ If you are not the sick person, but one of the exposed, & you can walk-up/drive-up (NOT indoors & ONLY in a 😷!) to #GetVaccinated, do it. If age 16+ & 6+ mos post dose 2 of vaccine (or 2+ post J&J), go #GetBoosted now! The booster protects w/in a wk! Vaccines.gov
18/ If you are just reading this crisis 🧵 & being 😅 it doesn’t apply, know that if you are indoors w/ people from outside your household, you WILL be exposed to #Omicron. The only Q is whether you’ll get infected. If you wear a very good 😷 & are careful, you CAN prevent it.
19/ If you are high-risk #immunocompromised or #immunosuppressed, we know that #vaccineswork less well in many of you. While you should still #GetVaccinated & #GetBoosted, an injection (Evusheld) can ⬇️⬇️ your risk of #COVID19. It’s given every 6 mos. fda.gov/news-events/pr…
20/ This 🧵 doesn’t include every single thing you or your dr can do for #Omicron, & it shouldn’t be read as medical advice. It’s info. Unfortunately everyone in #MedTwitter is swamped both officially at work & at home w/ sick pts, so this is my attempt to help inform all. /End
21/ P.S. Routine infection control measures still matter. #WashHands, etc. Don’t forget #commonsense.
When can you get back to life after having/being exposed to #Omicron? See 👇from @CDCgov. If you were 🤒, #GetVaccinated, if not already, or #GetBoosted in 10+ days. #MedTwitter
In case you’re wondering how your mask will fare in this #Omicron #Christmas gathering scenario, read this tweet & the one just after it in the same thread. #GetOutside! 😉
For those who cannot find or do not meet criteria for the existing monoclonal antibodies or pills to treat #COVID19, consider enrolling in #clinicaltrials online. They ship meds to your home & can help us find new treatments for #Omicron. #MedTwitter

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More from @tmprowell

26 Dec
🧵 Shared from a dr friend, details changed for patient privacy: Had 3 unvaxxed women in late pregnancy hospitalized w/ #COVID19 w/ emergency early deliveries. One dead, leaving 5 kids; one transferred out of state for ECMO (my note: most advanced life support) & dying anyway…
2/ One survived but had a stroke that left her with neurological disability so she will not be able to return to her home. Instead, she’ll spend her New Years’ Eve in a brain rehab. All the babies are expected to live, but these families are 💔. Two young moms dead, one disabled.
3/ #COVID19 is very dangerous in #pregnancy. The risk of death from #Covid is 22 times ⬆️ if you are #pregnant. The risk of stillbirth is doubled. Both @CDCgov & @ACOGPregnancy strongly rec to #GetVaccinated & #GetBoosted at ANY point in pregnancy, yet 2/3 in 🇺🇸 are unvaxxed.
Read 7 tweets
23 Dec
🧵 Your risk of dying if you get #Omicron in the next few wks as opposed to a few months from now will be dramatically different. We are facing huge surges in Jan that will make it hard to get seen in an ER in a timely fashion & even harder to get admitted to a hospital.
2/ Should you be fortunate enough to find a bed, you will have drs & nurses overwhelmed with patient volume, who will have very limited time to spend w/ you. Dr to patient (& nurse to patient) ratios will be unsafe, like unthinkable in pre-#pandemic times. #Omicron #MedTwitter
3/ This alone will dramatically increase your odds of death. That’s been seen in the prior surges. With #Omicron, the # falling ill at once is 🚀 off the charts. I’m seeing attack rates of 75-100% even in fully #vaccinated (& some #boosted) gatherings & households. #MedTwitter
Read 13 tweets
23 Dec
📣#Preprint #COVID19 #ConvalescentPlasma
📌RCT (N=1.2K)
📌Outpatients age 18+
📌High-titer CCP (>1:320) vs placebo plasma w/in 9d of symptoms
📌Primary endpt: Hosp/death by d28
📌CCP 🏆: 54% ⬇️, driven by non-ICU hospitalizations (NNT=29); HR 0.46, p<.01
medrxiv.org/content/10.110…
2/ A few important points about this #COVID19 #convalescentplasma trial
📌High-titer CCP was much higher than that used in some other studies (median titer of >1:14,580 & 95% had >1:4820)
📌Median days to plasma: 6d
📌53 of 54 hospitalizations were in unvaxxed (#GetVaccinated!)
3/ 📌 Only 3 deaths in post-hosp period, all in controls
📌 Few #COVID19nCancer or #immunocompromised
📌 Study used #convalescent plasma mostly from Apr-Dec 2020 (ie pre-#vaccine availability)
📌Would *predict* CCP from #vaccinated to perform well vs #Omicron & #covidvariants
Read 9 tweets
21 Dec
Got the contact tracing call yesterday for 2 of my kids:
-My middle schooler: friend in same lunch bunch has #COVID19. This is 2nd person in that group this yr. My kid has insisted they do lunch outside EVERY day, 🥵 🌧 🥶. NO secondary cases have occurred so far in the group 👍
-My high schooler: person few ft away tested positive for #COVID19. Often wore mask below her nose. My kid has worn a high quality mask consistency & correctly all yr. So far so good. I just texted her. Spontaneous response.

Kids are always watching. Teach them well! Image
This is not impossible. Will we end up with one or more of the kids getting #COVID19 at some point? Probably. But they’re all #vaccinated. Those elig are #Boosted. We wear quality masks indoors. We stay outdoors as much as we can. We open windows. We use EVERY tool & then live.
Read 4 tweets
20 Dec
🧵I have to say it: Christmas break is going to be bad. I'm watching confirmed #COVID19 cases⬆️ exponentially at our highly-#vaccinated school w/ a #MaskMandate & HEPA filters in every class. Make a plan now for how you'll handle Xmas & #quarantine when someone gets #Omicron.
2/ Think about how you can create a separate space for the person(s) infected. Remember #OmicronIsAirborne. Pick a rm w/ windows to open & its own door if your home allows. Today put a fan there that can be used to improve air exchange. Put a 🌡️, an O2 sat monitor, good masks.
3/ Go get a MERV13 filter for your HVAC at Home Depot or Lowe's or online. While here, get the stuff to build a simple, inexpensive, highly-effective Corsi-Rosenthal box. You can see what this is here. Build it now so it's ready.
Read 15 tweets
20 Dec
I’ve been contacted 2x just this wk—1 IRL acquaintance & 1 person I know only via Twitter—after they got imaging results in portal before their dr. They DM’d w/ screenshots, panicked, asking for help. I’m 💯 for pt access to #EHR, but #CuresAct implementation needs a MAJOR reboot
Whenever I have expressed concern about #CuresAct, #advocacy often tells me it’s still better. But it def was not better for these folks, nor for me dropping everything to help ppl who aren’t my pts, whose records I lack, & whose drs I don’t even know, i.e., it’s bad care. 😔
And I’m always happy to help patients, genuinely. I actually started using Twitter to be able to report out from #SABCS17 (I think) for #advocacy. But I don’t like providing bad medical care, & this is a set-up for doing so. We need a systems fix so pts aren’t left hanging…
Read 4 tweets

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