Thing is… even prior to #COVID19, it was known that viral shedding can occur in feces up to 3 weeks or longer. Isolation periods have always been subjective. That said, for airborne spread, there is a need to take precautions while infectious in that way #Omicron
https://twitter.com/imgrund/status/1477326269637435398
Specific to #COVID19 (in #Pediatrics)
“duration of viral shedding in infected pediatric patients. Virus was detectable for a mean (SD) of 17.6 (6.7) days overall and was detectable for a prolonged period of time in all cohorts of children”
jamanetwork.com/journals/jamap…
“duration of viral shedding in infected pediatric patients. Virus was detectable for a mean (SD) of 17.6 (6.7) days overall and was detectable for a prolonged period of time in all cohorts of children”
jamanetwork.com/journals/jamap…
Then this.
“Duration of symptoms ranged from 1 to 36 days. Positive tests were recorded up to a median of day 21 (range 6-38).”
pubmed.ncbi.nlm.nih.gov/33911876/
“Duration of symptoms ranged from 1 to 36 days. Positive tests were recorded up to a median of day 21 (range 6-38).”
pubmed.ncbi.nlm.nih.gov/33911876/
Viruses in general do this:
“duration of viral shedding was 51.4 days (y = 9.558-0.186x). The median viral load of the HAdV-7 group at weeks 2 and 3, and more than 3 weeks”
We have always sent ppl back to work/school while still shedding (& + test)
pubmed.ncbi.nlm.nih.gov/33565614/
“duration of viral shedding was 51.4 days (y = 9.558-0.186x). The median viral load of the HAdV-7 group at weeks 2 and 3, and more than 3 weeks”
We have always sent ppl back to work/school while still shedding (& + test)
pubmed.ncbi.nlm.nih.gov/33565614/
BUT.. difference between detectable & infectious
“SARS-CoV-2 RNA shedding in respiratory and stool samples can be prolonged, duration of viable…short-lived. SARS-CoV-2 titres in the upper respiratory tract peak in the first week of illness”
thelancet.com/journals/lanmi…
“SARS-CoV-2 RNA shedding in respiratory and stool samples can be prolonged, duration of viable…short-lived. SARS-CoV-2 titres in the upper respiratory tract peak in the first week of illness”
thelancet.com/journals/lanmi…
Also, peak transmission is *before* symptoms (virus furiously replicating in new host)
“infectiousness peaked on or before symptom onset …44% (95% confidence interval, 30–57%) of secondary cases were infected during the index cases’ presymptomatic stage
nature.com/articles/s4159…
“infectiousness peaked on or before symptom onset …44% (95% confidence interval, 30–57%) of secondary cases were infected during the index cases’ presymptomatic stage
nature.com/articles/s4159…
@CDCgov not requiring negative test to go back to work itself is not unreasonable. Back in 2020 there was a a 10 vs 7 day quarantine debate
“interpretation of the infectivity of a person based on a positive PCR test can be inaccurate.”
ncbi.nlm.nih.gov/pmc/articles/P…
“interpretation of the infectivity of a person based on a positive PCR test can be inaccurate.”
ncbi.nlm.nih.gov/pmc/articles/P…
The worst/most transmission/infectious ness may be just for one day
“We identify that people infected with SARS-CoV-2 or influenza can be highly contagious for less than 1 day, congruent with peak viral load”
elifesciences.org/articles/63537
“We identify that people infected with SARS-CoV-2 or influenza can be highly contagious for less than 1 day, congruent with peak viral load”
elifesciences.org/articles/63537
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