A new paradigm in Vascular Bone axis in CKD. Klaus Olgaard #ERAEDTA18 
Activin A and sclerostin as markers. #ERAEDTA18
Diminished aortic calcification using a ligand trap caused less aortic calcification in rats. #ERAEDTA18
Mutation in Klotho results in a syndrome resembling ageing. The Klotho molecule has a bended arm as this painting. #ERAEDTA18
FGF 23 produced in osteocytes. Kloto expressed in kidneys. Transmembrane protein mainly in distal tubule. sKloto found in urine and plasma. #ERAEDTA18
Relationship in Mammals between Serum Phosphate and logevity. Number 12 is a naked mole rat, number 1 is a Kloto+ mouse. #ERAEDTA18
Kloto supplementation extends lifespan of Kloto mutant mice #ERAEDTA18
mKloto is not found in aorta. As such sKloto is important for vascular effects. Kloto production and expression depends on kidney mass. #ERAEDTA18
The pleiotrophic effects of Kloto depends on FGF23. #ERAEDTA18
A longitudinal increase in FGF23 correlates with an increase mortality. FGF23 drives CKD MBD. Extraskeletal synth of FGF23 in injured kidney may result in elevated levels #ERAEDTA18
FGF23 production in Kidney not influenced by Parathyroidectomy #ERAEDTA18
Kidney derived FGF 23 does not contribute to elevated levels. But clearance of FGF23 does. #ERAEDTA18
The calcium sensing receptor and it's relationship to HyperPO4 and HypoCa2+ #ERAEDTA18
#ERAEDTA18 summary
