Lots of headlines @escardio re CT-FFR. 1 of most prominent is ADVANCE multicenter registry from @manesh_patelMD & colleagues using @HeartFlow. I'd like to dissect this a bit to see how excitement in a field combined with lots of industry funding can blind us to basic problems.
Team worked across 38 international sites over >2 years to collect data from N=5083 patients w/ “symptoms concerning for CAD”. They had primary endpoint of change in management plan from coronary CTA. That happened in 67% of patients. Most impressive.
Is this a valid endpoint? I contend that this is a measurement of physician psychology rather than of anything objective.