Discover and read the best of Twitter Threads about #MRA

Most recents (24)

1) Welcome to our new #accredited #tweetorial which is Part 2 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this 🧵!
2a) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. Our expert author is Dr. Clara García Carro (@ClaraGCarro) from San Carlos Clinical Hospital (Madrid, Spain).
2b) Be sure to check out the first half of this #ERA22 recap from my colleague @shbermejo, and get MORE 🆓CE/#CME at ckd-ce.com/dkd12_ERA22a/. Join me in following @ckd_ce for the BEST in #cardiorenal education delivered entirely by #tweetorial!
Read 48 tweets
Medical Therapy for Functional #MR

#GDMT is the first step and prevails as the mainstay in the treatment of #FMR

This review addresses the medical Tx options for FMR Mx and highlight a targeted approach for each FMR category

#HeartFailure #VHDs ahajournals.org/doi/10.1161/CI… @CircHF
#GDMT plays a pivotal role in LV reverse remodeling (LVRR) in FMR and leads to reduction in severity and improved outcomes for both atrial and ventricular #FMR

#GDMTWorks #VHDs #HeartFailure
Studies report 28% to 50% reduction in grade of #FMR from baseline in patients receiving optimal or maximally tolerated doses of #GDMT (including diuretics) in both ischemic #cardiomyopathy and non-ischemic CMP

#GDMTWorks #VHDs #MR
Read 8 tweets
Ireland's GRA 2015 was "an extraordinarily high-profile piece of legislation, with all the accompanying media coverage, political debates and processes", claims Mulally, in @IrishTimes. Check Google search results for the topic from 1/1/2014 - 31/12/2015: google.com/search?q=gende…
Google Trends data for 1/1/2007 (the year of Lydia Foy's High Court win regarding changing factual birth cert to one recognising "legal gender") to 31/12/2016. The GRA was enacted on 15/7/2015 (blue peak on graph below). Does this look like it was "extraordinarily high-profile"?
The #DentonsDocument lobbying playbook recommends piggybacking gender ID legal changes on more popular reforms, citing Ireland's marriage equality legislation as providing a "veil of protection" to GRA, which was "more difficult to win public support for". spectator.co.uk/article/the-do…
Read 10 tweets
🚨 #URGENTE Más imágenes del terrible accidente ocurrido hace minutos sobre la ruta Transchaco.
🚫 La distracción + imprudencia fueron los factores que agravaron la escena, donde posterior al accidente, curiosos ocasionaron más percances graves.
[HILO]
Aparentemente, el conductor del automóvil Marca Toyota Vitz Color Azul, realizó una frenada imprudente en vista al accidente ocurrido, donde podemos presumir que el vehículo tipo Camión de Mediano porte también se encontraba distraído por la situación y terminaron chocando
Por si fuera poco, el Toyota Vitz azul, mientras era retenido por personal Policial para las debidas diligencias por el anterior percance, termina generando otro accidente contra un Motociclista que viajaba a alta velocidad. 🚨
#URGENTE #graveaccidente #MRA #viral #curiosos
Read 6 tweets
1) Welcome to a new #accredited #tweetorial, Prevention and Management of Heart Failure in T2 Diabetes: The Diabetologist’s Perspective! Our expert author is Melanie J Davies CBE FMedSci @profmjdavies, Prof of Diabetes Medicine, U Leicester, Leicester Diabetes Unit @LDC_Tweets
2) This program is intended for #healthcare professionals and is accredited by @academiccme for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists 🇺🇸🇨🇦🇬🇧🇪🇺. FOLLOW US for #cardiometabolic education from expert authors!
3) @cardiomet_CE is supported by educational grants from AstraZeneca, Bayer, Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company, and Chiesi. See archived programs still available for credit at cardiometabolic-ce.com. Disclosures at cardiometabolic-ce.com/disclosures/
Read 43 tweets
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Read 48 tweets
1) Welcome to a new #accredited #tweetorial on Cardiorenal Disease in T2D & the Impact of Blocking the MR in Patients w/DKD, another CE/#CME program by one of the @GoggleDocs, this time our friend @AmarPut, Diabetes & Endocrine Consultant in the West Midlands 🇬🇧. #CaReMe #FOAMed Image
2) This program is supported by an educational grant from Bayer & is intended for #healthcare providers. Author disclosures can be found at ckd-ce.com/disclosures/. Prior programs, still available for CE/#CME credit, are at ckd-ce.com. CE/#CME credit 🇬🇧🇪🇺🇨🇦🇺🇸
3) So first – the ‘triple threat’ . . . We know of the link between the 🫀 and the kidneys and the ‘#cardiorenal’ syndrome, but what about in the setting of #diabetes?
Read 55 tweets
In patients with #HFpEF, treatment with #empagliflozin improves clinical outcomes regardless of background #MRA therapy

jacc.org/doi/10.1016/j.…
@JACCJournals #JACC @unic_cardiovasc @JavedButler1 @FaiezZANNAD #MiltonPacker @robmentz @BiykemB @HFpEF @ShelleyZieroth
#MRAs were used in 37% of EMPEROR-Preserved study participants. MRA use was higher in those with a more congested clinical picture, with more HF🏥 within the past 12 months, worse HF symptoms, mildly reduced EF, higher NT-proBNP levels, and more use of loop diuretic agents
The effect of empagliflozin to reduce HF 🏥 was more pronounced in MRA nonusers than in MRA users, particularly in the subgroup of patients with LVEFs ≥50% @HFpEF @DrRyanPDaly @AndrewJSauer @AnastasiaSMihai @DrMarthaGulati @ErinMichos @ShelleyZieroth @mvaduganathan
Read 8 tweets
1) Welcome to a new #accredited #tweetorial from our good friends and #diabetes experts @GoggleDocs, specifically @drkevinfernando, @drpatrickholmes, & @AmarPut. They have put their 🗣️s together to provide us with a summary of the first-ever consensus statement from ...
2) ... @AmDiabetesAssn & @goKDIGO, which were discussed at the recently concluded #isnwcn congress in Kuala Lumpur. This joint document nicely summarizes important recent advances and practice-changing data for the management of diabetic #kidneydisease #DKD.
3) This program is #accredited for CE/#CME #physicians #physicianassociates #nurses #pharmacists #nursepractitioners & is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US based healthcare professionals.
Read 29 tweets
1) Welcome to our new #accredited #tweetorial on risk stratification to identify the patient with #T2D and #DKD most at risk for rapid progression to advanced CKD. I am Christos Argyropoulos MD, PhD (@ChristosArgyrop), Division Chief, Nephrology, @UNMHSC.
2) This #accredited #tweetorial series on #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Read 45 tweets
1) Welcome to our new #accredited #tweetorial on #mechanismofaction & impact of meds commonly used in patients with or at risk for #DKD progression: #MRAs, #GLP-1 receptor agonists & #DPP-4 inhibitors. I am Sophia Ambruso DO, @sophia_kidney, from @CU_Kidney. Image
2) This #accredited #tweetorial series on #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Read 62 tweets
1) Welcome to a new #accredited #tweetorial on currently available treatments for mineralocorticoid receptor (MR) antagonism (#MRA), the differences among them, and how these differences impact on treatment of cardio-reno-metabolic diseases #CaReMe #FOAMed
2) Our expert author is Dr. Patrick Holmes MB BS, MSc, DipTher, MRCGP (@drpatrickholmes), a GP Partner at St. George’s Medical Practice, Darlington for 23 years. He is a Trustee for the Primary Care Diabetes Society and is Associate Editor for Diabetic Medicine @diabeticmed.
3) This program is supported by an educational grant from Bayer & is intended for #healthcare providers. Author disclosures can be found at ckd-ce.com/disclosures/. Prior programs, still available for CE/#CME credit, are at ckd-ce.com. CE/#CME credit 🇬🇧🇪🇺🇨🇦🇺🇸
Read 35 tweets
#BhaiKeJhooth
Lie ) She accused MS of being Harrasser?

Truth) She said that MS let the guy who harrassed her speak AND DIDN'T REMOVE HIM. IN FACT HE TURNED BACK AND ASKED HER ABOUT NASEERUDDIN SHAH

This behaviour is called

ENABLING THR HARRASSER

She felt that they enabled++
++

Lie) How can you throw MS host under the bus. There were tweets against her

Truth)The MS made someone feel that he enabled the harrasser. They were well within their right to feel so. The tweets on MS were made by a lot on Twitter

YOU CHOSE TO PUNISH THAT GIRL

DELIBERATELY
Lie) MS doesn't harass people?

Truth) That's a strawman. Cause that isn't even accusation

HE ENABLED

Lie) Abuses can't be tolerated

Truth) The current cohost used TH0T which is a slang for calling a woman WH0R€

He is Co host currently
Read 50 tweets
(1) Welcome to this #accredited #tweetorial, on recent & emerging data on finerenone, a non-steroidal mineralocorticoid receptor antagonist. We’ll discuss what it is, what evidence supports its use, & where it might fit into future #renal guidelines. I am @drkevinfernando.
(2) This program is supported by an educational grant from Bayer and is intended for #healthcare providers. Author disclosures can be found at ckd-ce.com/disclosures/. Prior programs, still available for CE/#CME credit, are at ckd-ce.com.
(3) Let's start with a knowledge check.
The following therapeutic options have demonstrated a significant reduction in the progression of both #CKD and #cardiovascular mortality in people living with #T2D:
1. ACEi's & ARBs
2. Spironolactone
3. SGLT2 inhibitors
4. Finerenone
Read 38 tweets
Do You keep slamming Your face because You missed the 1st #HFA @escardio Clinical Practice Update Course on #HeartFailure, orchestrated masterfully by MC Mullens?

Are You particularly disappointed to have missed the clinical pearls of #HFA giants @kevin_damman & @FinnGustafsson?
Catch up for 2 months on the platform on demand: escardio.org/Education/Cour…

I'll release just a teaser under the form of a clinical case below. You might call on my partners in crime @Ph_Bertrand & @petranijst to do the same...

Have fun & see you live without #COVID next year!
@Ph_Bertrand @petranijst 61 y/o woman
PMH: Chronic HCV, hypertension, poorly controlled diabetes (HbA1c 9.6%), obesity (BMI 32 kg/m²)
Currently no meds

Found in apartment with motoric aphasia & right hemiplegia due to ischemic stroke (middle cerebral artery)
R/No thrombolysis (subacute), thrombectomy!
Read 27 tweets
Don’t miss a new accredited #tweetorial launching TOMORROW here on @cardiomet_ce. #Emergencymedicine researcher and devotee of deep understanding of drug mechanism of action @md_pollack will be considering why being #nonsteroidal means better #MRA. Don't miss it! @GoggleDocs
1) Welcome to a #tweetorial where we’ll explore the mechanism of action of mineralocorticoid receptor antagonists (#MRA) & consider why it's so #vogue to be #nonsteroidal. This program is accredited for 0.50 credits for #physicians #nurses #pharmacists. I am @md_pollack. #FOAMed
Read 51 tweets
🔴#ErinPizzey 🔴

« (...) Como tantas mujeres de mi edad, me involucré al principio del movimiento femenino emergente y me llamé a mí misma feminista de la "equidad". Estaba interesada en asegurarme de que hombres y mujeres pudieran competir entre sí en igualdad de condiciones.⬇️
Las feministas radicales son ahora, como lo eran entonces, diferentes de la mayoría de las feministas, y son muy poco representativas de las mujeres en general. Odian a los hombres y quieren igualdad de género en los resultados, a cualquier precio, independientemente de lo que ⬇️
hombres y mujeres decidan hacer en su vida personal y laboral.
Rápidamente me desilusioné cuando vi que el movimiento de mujeres nunca tuvo la intención de ser un movimiento para la mayoría de las mujeres. Fue un intento por parte de las mujeres militantes del marxismo, ⬇️
Read 12 tweets
#WeekendLecture
Intracranial Atherosclerotic Disease #ICAD

#ICAD leads to changes ranging from minor wall thickening to #hemodynamically significant luminal stenosis and is one of the most #common causes of #stroke worldwide
ahajournals.org/doi/10.1161/CI…

🧵 Image
#WeekendLecture
#ICAD

✅10% of stroke, based on autopsy studies
bit.ly/3v6Lhrd
✅More prevalent in #African Americans, #Hispanics, and #Asians as compared with whites
bit.ly/3AuSiDt

Other risk factors in table Image
#WeekendLecture
#ICAD

In postmortem studies
👉degree of luminal #stenosis
👉% of the plaques containing >40% #lipid area
👉prevalence of intraplaque #hemorrhage, #neovasculature and #thrombus,
were higher in those #plaques associated with #infarct
🔹karger.com/Article/Abstra… Image
Read 13 tweets
⛔️ APOYAR AL FEMINISMO ES UN ATAQUE A LOS HOMBRES.

La teoría del patriarcado, la articulación moderna de toda la base del feminismo, demoniza a toda la población masculina como opresores abusivos.

Atacar a #MRA también es un ataque a los hombres; ⬇️ ImageImage
a lo que te opones es a la defensa de una reforma real.

El feminismo no hace más que hablar sobre las formas en que las académicas feministas piensan que los hombres son defectuosos.

La "solución" del feminismo a todos los problemas de los hombres es: ⬇️ Image
"SÉ MÁS COMO LAS MUJERES Y NO TENDRÁS ESOS PROBLEMAS".

Las feministas llaman "misóginos" a los hombres (y yo añado, también a las mujeres) que buscan reformas legales y sociales e igualdad de derechos humanos.

Palabras de la gran #HannaWallen
@Oneiorosgrip

#honeybadger #mra Image
Read 4 tweets
#WeekendLecture
#CarotidArteryDisease #CAD

#CAD causes ~ 10-20% of #strokes
Atherosclerosis occurs most frequently at carotid #bifurcation, an area of low vessel-wall shear stress and oscillatory/turbulent blood flow

Welcome to this mini review!
#WeekendLecture
#CAD
Endothelial dysfunction
⬇️
Inflammatory response to Lp retention in arterial wall
⬇️
Accelerated accumulation of Lp in subendothelial matrix
⬇️
Macrophages
⬇️
VSCM migrate/proliferate to fibroblast-like cells👉 production of EC matrix
atm.amegroups.com/article/view/7…
#WeekendLecture
#CAD
Stroke Mechanisms
#artery_to_artery embolization: retinal (amaurosis fugax) or cerebral circulation
#thrombosis in situ
#Flow reduction in high grade stenosis: #watershed infarcts, repetitive and brief TIAs (ie limb shaking)

nejm.org/doi/full/10.10…
Read 12 tweets
🆘♂️COMO AFECTA EL #ABORTO A LOS HOMBRES.
Es urgente visibilizar y poner atención en como el aborto espontáneo afecta en la salud mental de los padres. Con el fin de prestar el apoyo necesario en un proceso traumático para ambos integrantes de la pareja⤵️
menshealth.com/uk/health/a363…
Asumir el aborto desde una perspectiva masculina, implica no descuidar su dolor, a pesar del lógico apoyo que ofrece a su pareja. Pareja que a su vez, pasa por un proceso físico y mental. El duelo del hombre suele llegar más tarde, al ver que su pareja se recupera.⤵️
El hombre tiende a dejar temporalmente de lado su propio dolor, su duelo. Siente impotencia al ver que no puede hacer mucho por la mujer a la que ama. Sabe que ella sufre, y se enfrenta a un proceso físico desconocido, sobre el que ningún integrante de la pareja tiene control⤵️
Read 16 tweets
DRAADJE 1/8 voor iedereen die wil weten hoe het kon gebeuren dat er op #IJburg naast woningen MEGA-#WINDTURBINES kunnen worden geplaatst en wie er verantwoordelijk zijn voor dit desastreuze beleid.

Spoiler: vooral de @VVD en @GroenLinks zijn schuldig👇volkskrant.nl/nieuws-achterg…
2/8 Als gevolg van de Regionale Energiestrategie (#RES) moeten verschillende regio's zoekgebieden aanwijzen voor de opwek van duurzame energie. Dit zorgt in gemeenten als Amsterdam voor problemen vanwege ruimtegebrek en de geldende regels voor plaatsing #windturbines.
3/8 Tot voor kort werden burgers namelijk nog enigszins beschermd tegen mega-#windturbines. De minimale afstand tot woningen was 600 meter (alsnog te dichtbij). Deze norm maakt het in Amsterdam echter onmogelijk om windturbines te plaatsen en dus invulling te geven aan de #RES.
Read 8 tweets
PPEs/Masks/Face Shields delivered to JK Bencana Negeri Sabah @ SUK Office.
Dr Liow JKN Sabah & Datin Li Kuan State Anaesthetist notified for distribution & follow up.
3rd consignment
Compliments of #DemiNegara
@theedgemalaysia
#MRDIY
#MRA
#IMARET
#MERCY @simkuihian @DrDzul ImageImageImageImage
3rd consignment sent to Unit Keselamatan dan JK Bencana Negeri Sarawak. MRA Sarawak offering logistic services to enhance distribution. MRA team on high alert waiting for their consent to assist distribution @simkuihian @DrDzul ImageImageImageImage
Total 35 ventilators and 30 Oxygen Concentrators for Sabah and Sarawak. Delivered to respective JK Bencana Negeri. Hopefully distributed to #COVID Hospitals ASAP @KKMPutrajaya @theedgemalaysia @simkuihian @DrDzul ImageImage
Read 4 tweets
What’s Your “Shear Stress”?

Want to Know More?

Relax & Read ⤵️ #Tweetorial by @CoronaryDoc + @arnavkumar

⚡️Coronary Wall Shear Stress in 12 Tweets ⚡️

1/12
Main Readings:
1) interventions.onlinejacc.org/content/early/…
2) ow.ly/XmD130mc9X8
3) link.springer.com/article/10.100…
#ACCImaging @ACCCardioEd
2/12
Wall shear stress (#WSS) is the frictional force of blood exerted tangential to endothelial surface of vessel wall & expressed in variety of units (1Pa=1N/m2=10 dynes/cm2)

It is derived from
• luminal geometry
• flow rate
• blood viscosity
• near wall velocity values
3/12
In vivo WSS calculations are derived from computational fluid dynamic (#CFD) simulations created from reconstructed 3D vessel geometries (from biplane angio/IVUS/OCT/CT/MR) combined with patient-specific pulsatile inlet/outlet velocity values (Doppler wire or other methods)
Read 12 tweets

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