Discover and read the best of Twitter Threads about #hdl
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🧵 Dec 9th anniversary thread
On this day in 2015 I received a lab result that would alter the course of my life.
Just two weeks earlier I had gotten my very first bloodwork after half a year on #keto that showed my total and #LDL #Cholesterol had nearly doubled (!)… /1
On this day in 2015 I received a lab result that would alter the course of my life.
Just two weeks earlier I had gotten my very first bloodwork after half a year on #keto that showed my total and #LDL #Cholesterol had nearly doubled (!)… /1
2/ With that first test I was overcome with shock and curiosity — much more former than the latter.
I wanted to get a repeat test to confirm this wasn’t a lab error.
I wasn’t ready to give up #keto, but I was miserable enough that I ate considerably less.
I wanted to get a repeat test to confirm this wasn’t a lab error.
I wasn’t ready to give up #keto, but I was miserable enough that I ate considerably less.
3/ At the same time I learned as much as I could about Lipidology - which focuses on how the body moves lipids (like cholesterol) in the blood.
And to my surprise, this system is already very familiar to me as a software engineer given it is a distributed object network.
And to my surprise, this system is already very familiar to me as a software engineer given it is a distributed object network.
🧵1/8 Here's an easy thread for reference on our current papers. 👇👇👇
🔖 Bookmark this!
We cover:
- High #LDL on #lowcarb/#keto
- Lean Mass Hyper-responders (#LMHR)
- The Lipid Energy Model (#LEM)
- And, ofc, our #LMHRstudy underway right now
🔖 Bookmark this!
We cover:
- High #LDL on #lowcarb/#keto
- Lean Mass Hyper-responders (#LMHR)
- The Lipid Energy Model (#LEM)
- And, ofc, our #LMHRstudy underway right now
2/8 The #LMHRpaper was our first describing the #LMHR phenotype
- #LDL #Cholesterol of 200 or higher
- #HDL #Cholesterol of 80 mg or higher
and
- #Triglycerides of 70 mg or lower
Which is actually common for lean, very folks on #lowcarb/#keto folks. doi.org/10.1093/cdn/nz…
- #LDL #Cholesterol of 200 or higher
- #HDL #Cholesterol of 80 mg or higher
and
- #Triglycerides of 70 mg or lower
Which is actually common for lean, very folks on #lowcarb/#keto folks. doi.org/10.1093/cdn/nz…
3/8 Our second paper brings a case report on a single #LMHR with extremely high #LDLc (~500 mg/dL) for 2.5 years, their eating patterns, and current CT angiography.
(⚠️Please note this is a single case report and should be considered anecdotal, ofc) doi.org/10.3389/fendo.…
(⚠️Please note this is a single case report and should be considered anecdotal, ofc) doi.org/10.3389/fendo.…
1/ Alright, let's chat the #NHANES (IV)
As usual, I'll give my caveats this is back-of-the-envelope on data I wrangled via CDC on this expansive dataset -- and it's associational, ofc (observational)
So what are the lipids like for those who live to 100yr in NHANES?
As usual, I'll give my caveats this is back-of-the-envelope on data I wrangled via CDC on this expansive dataset -- and it's associational, ofc (observational)
So what are the lipids like for those who live to 100yr in NHANES?
2/ Remember, these aren't the lipid levels taken *at* age 100+, it's what their levels where at the time of examination 15-20 years prior.
This is very relevant when considering reverse causality given this extreme gap in time for all who were reaching centenarian status.
This is very relevant when considering reverse causality given this extreme gap in time for all who were reaching centenarian status.
3/ First up -- #LDL #Cholesterol.
Yes, 73% of you correctly guessed 130mg/dL is the mean average for these 32 individuals (lipids taken age 85 or earlier).
LDL mean average: 130 mg/dL
0% 25% 50% 75% 100%
72.0 102.5 126.0 154.0 215.0
Yes, 73% of you correctly guessed 130mg/dL is the mean average for these 32 individuals (lipids taken age 85 or earlier).
LDL mean average: 130 mg/dL
0% 25% 50% 75% 100%
72.0 102.5 126.0 154.0 215.0
1/4 Back-of-the-envelope:
There are now 32 NHANES participants with lipids & mortality data who have lived to at least age 100 (age + followup > 100yr.), thus earning the designation of "centenarian"
What was mean avg #LDL-C for this group from their bloodwork 15-20yrs prior?
There are now 32 NHANES participants with lipids & mortality data who have lived to at least age 100 (age + followup > 100yr.), thus earning the designation of "centenarian"
What was mean avg #LDL-C for this group from their bloodwork 15-20yrs prior?
2/4 What was the mean average #HDL #Cholesterol (#HDL-C) for this group from their bloodwork 15-20yrs prior?
3/4 What was the mean average #Triglyceride (TG) levels for this group from their bloodwork 15-20yrs prior?
Let's review quickly all of the science I've come across in the past week that applies to high-fat ketogenic carnivore type diets.
I'll post the link, an image of the abstract, the title, and some hashtags on each one.
1/n - My public Zotero Database:
zotero.org/groups/2466685…
I'll post the link, an image of the abstract, the title, and some hashtags on each one.
1/n - My public Zotero Database:
zotero.org/groups/2466685…
2/n
Red and processed meat intakes and cardiovascular disease and type 2 diabetes mellitus: An umbrella systematic review and assessment of causal relations using Bradford Hill’s criteria
"do not support causality"
#T2D #CVD #SystematicReview #RedMeat
tandfonline.com/doi/full/10.10…
Red and processed meat intakes and cardiovascular disease and type 2 diabetes mellitus: An umbrella systematic review and assessment of causal relations using Bradford Hill’s criteria
"do not support causality"
#T2D #CVD #SystematicReview #RedMeat
tandfonline.com/doi/full/10.10…
Do #Vegetarian Diets Provide Adequate Nutrient Intake during Complementary Feeding? A Systematic Review
Complementary Feeding is the period when you're weaning a child onto non-breastmilk foods.
TLDR: "Not safe, critical micronutrient deficiency risk"
mdpi.com/2072-6643/14/1…
Complementary Feeding is the period when you're weaning a child onto non-breastmilk foods.
TLDR: "Not safe, critical micronutrient deficiency risk"
mdpi.com/2072-6643/14/1…
📊Polls ahead of #KetoSaltLake
Poll (1/4)
Lean Mass Hyper-responders (#LMHRs) are defined by:
+⬆️#LDL #Cholesterol at 190mg (5.17mm) or higher,
+⬆️#HDL-C 80 (2.07) or higher &
+⬇️#Triglycerides of 70 (0.79) or lower
In your opinion, cardio risk level of this profile is likely
Poll (1/4)
Lean Mass Hyper-responders (#LMHRs) are defined by:
+⬆️#LDL #Cholesterol at 190mg (5.17mm) or higher,
+⬆️#HDL-C 80 (2.07) or higher &
+⬇️#Triglycerides of 70 (0.79) or lower
In your opinion, cardio risk level of this profile is likely
Poll (2/4)
Many demonstrating the #LMHR phenotype (but not all) consume a diet...
High in animal protein
High in red meat
High in saturated fat
In your opinion, if we were to further stratify the #LMHR population to those with the above diet, their cardio risk level would be...
Many demonstrating the #LMHR phenotype (but not all) consume a diet...
High in animal protein
High in red meat
High in saturated fat
In your opinion, if we were to further stratify the #LMHR population to those with the above diet, their cardio risk level would be...
Poll (3/4)
When did you first hear of the Lean Mass Hyper-responder profile?
When did you first hear of the Lean Mass Hyper-responder profile?
1/ This new MR study by @mendel_random, @mvholmes, et al makes use of UK Biobank data and determines #ApoB increases risk of #AllCauseMortality, and even #T2Diabetes
This is actually relevant timing as we are rapidly approaching the #LMHRstudy. sciencedirect.com/science/articl…
This is actually relevant timing as we are rapidly approaching the #LMHRstudy. sciencedirect.com/science/articl…
2/ If you didn't already know, "Lean Mass Hyper-responders" (#LMHRs) would be considered hypercholesterolemic, with this resulting from being very low carb (typically #keto), and are often lean and/or athletic.
(You can read more on this phenotype at CholesterolCode.com/lmhr)
(You can read more on this phenotype at CholesterolCode.com/lmhr)
3/ Setting aside why this population exhibits this (see #LipidEnergyModel for more), the most important question is whether they are at risk.
This MR study builds on the existing conventional expectation that they are, and no less in a dose-dependent manner...
This MR study builds on the existing conventional expectation that they are, and no less in a dose-dependent manner...
#Dislipemias y enfermedades del #Colesterol. Parte I
¿De qué se tratan?
¿Cómo se interpreta un perfil lipídico en un laboratorio?
¿Qué son las #LDL pequeñas y densas y por qué son las que más interesan?
¿Qué es el Colesterol No HDL?
#AbroHilo
¿De qué se tratan?
¿Cómo se interpreta un perfil lipídico en un laboratorio?
¿Qué son las #LDL pequeñas y densas y por qué son las que más interesan?
¿Qué es el Colesterol No HDL?
#AbroHilo
➡️La #enfermedad #cardiovascular es la principal causa de muerte en la población general. Está asociada a decenas de patologías, entre ellas, #diabetes, #obesidad, #tabaquismo, enfermedades autoinmunes, etc; y la que veremos hoy: las dislipemias o enfermedades del colesterol.
➡️Las #Dislipemias son enfermedades causadas por alguna alteración en el metabolismo de los lípidos (colesterol y triglicéridos).
Pueden ser primarias-de causa genética, adquiridas-por determinados hábitos como 🍔🚬 y secundarias-asociadas a otras enfermedades.
#Sigue ⬇️
Pueden ser primarias-de causa genética, adquiridas-por determinados hábitos como 🍔🚬 y secundarias-asociadas a otras enfermedades.
#Sigue ⬇️
1/ For a very layperson-friendly video on conventional view of #LDL / #HDL #Cholesterol, and #ApoB, I highly recommend this one from @NutritionMadeS3
It's very visual and IMO fairly true to the more specific position of mainstream lipidology...
It's very visual and IMO fairly true to the more specific position of mainstream lipidology...
2/ Love his opening: "why is this topic so confusing? well, for starters scientists are horrible at coming up with names...there's LDL...and LDL cholesterol and they're different things....but a lot of people call them both LDL....and then there's HDL, VLDL..." (trails off)
3/ He's 100% right. It's why it's so hard to convert this for the lay audience. Lipidology could use a terminology upgrade.
For example, how did "Chylomicrons" manage to get a special exception to the "-DL" acronym party? (Only fellow lipophiles will get that joke... 😐)
For example, how did "Chylomicrons" manage to get a special exception to the "-DL" acronym party? (Only fellow lipophiles will get that joke... 😐)
1/ 😁Thread -- About Me -- 5 year update😁
It's been a busy 24 hours since @joerogan's podcast dropped where @CarnivoreMD discussed our work (mega thx, Paul!). There's been a surge of new followers, so I figured it was high time to do an update for those just tuning in...
It's been a busy 24 hours since @joerogan's podcast dropped where @CarnivoreMD discussed our work (mega thx, Paul!). There's been a surge of new followers, so I figured it was high time to do an update for those just tuning in...
2/ I'm a senior software engineer and systems architect having developed a variety of platforms over my career.
Five years ago next month I saw my cholesterol levels skyrocket on a ketogenic diet and was extremely interested as to the mechanisms behind it...
Five years ago next month I saw my cholesterol levels skyrocket on a ketogenic diet and was extremely interested as to the mechanisms behind it...
3/ I began learning everything I could about Lipidology and the system that moves #cholesterol around in our body. To my surprise, it has many structural things in common with a network (a very advanced one, mind you), but soon I was manipulating my own lipid levels easily.
1/ My presentation to @stanford on the Lipid Energy Model is now up at my channel.
It was a great honor to be invited and discuss my research, experiments, and this hypothesis in depth.
Lots of discussion on #LDL #HDL #Cholesterol #ApoB and #LipidTriad
It was a great honor to be invited and discuss my research, experiments, and this hypothesis in depth.
Lots of discussion on #LDL #HDL #Cholesterol #ApoB and #LipidTriad
2/ For many of you who have followed my work for a while, this will feel like review. But this presentation challenged me to tie everything together as best I could for a non-#keto/#lchf audience at a university level. Given the feedback /retention, it appears to have gone well..
3/ Of course, there's quite a lot that it *not* covered, and indeed I wanted to squeeze a bit more into it. Sometimes I wish I could summarize the energy delivery throughput and cross my fingers everyone at a certain level will get it. But that's been the biggest challenge...
1/ I consider #HDL extremely relevant, yes. It’s one of the existing five criteria for metabolic syndrome and one of the three for atherogenic dyslipidemia. ncbi.nlm.nih.gov/pmc/articles/P…
2/ It’s one of my three target markers for the #LCCholesterolChallenge (which is about to turn two years old next week). cholesterolcode.com/lccholesterolc…
I haven’t yet found any study that stratifies ⬆️LDL+⬆️HDL+⬇️TG showing ⬆️cardiovascular disease as of yet, but I’ve found the opposite
I haven’t yet found any study that stratifies ⬆️LDL+⬆️HDL+⬇️TG showing ⬆️cardiovascular disease as of yet, but I’ve found the opposite
3/ See studies linked in this LMHR article - cholesterolcode.com/cholesterol-en…
And I don’t have it handy as I’m on my phone, but we see this likewise stratification of the triad in the 4S trial...
And I don’t have it handy as I’m on my phone, but we see this likewise stratification of the triad in the 4S trial...
Extracellular acidity in atherosclerosis is one of my favorite topics, so I'm really, really excited about this study (2/15)
The authors show that some individuals have carotid atherosclerotic lesions that have an acidic pH. They show this is due to activation of Na+-H+ exchanger in macrophages, which leads to extrusion of H+ and extracellular acidification (3/15)
rdcu.be/bRXph
rdcu.be/bRXph
