Discover and read the best of Twitter Threads about #macrophages

Most recents (9)

🧵🪡A thread on our paper out in today’s @Dev_Cell issue, featuring one of my images on the cover 🤩 Image
You might’ve heard about the #BBB but have you heard about the BNB (Blood Nerve Barrier)? #pns #bloodnervebarrier Image
We showed that endoneurial blood vessels (EndoBVs) are surrounded by pericytes (alphaSMA, orange) 🤗 @ImarisSoftware
Read 14 tweets
SEMINAL ARTICLE re: #ICD11 Chapter 08 - Diseases of the #NervousSystem 🧠

Study Title: The #leptomeninges as a critical organ for normal #CNS development and function: first patient and public involved systematic review of #arachnoiditis (chronic #meningitis). @PLOSONE

#CES- #CaudaEquina Syndrome
#DLM – Diseases of the #Leptomeninges
#ESI- #Epidural Steroid Injection
LM - #Leptomeninges
#LMF- #Leptomeningeal #Fibrosis
#NAA- #neuraxialanesthesia
PSR- PRISMA Systematic Review
#SAH- #Subarachnoid Hemorrhage
#SAS- #Subarachnoid Space

Key Findings:

1. A varyingly described, and poorly characterized #CNS disease called #arachnoiditis (aka #adhesivearachnoiditis) was exhaustively systematically-reviewed for the first time.
Read 27 tweets
9) Many risk factors modulate the propensity of LDL-C to traverse the endothelium and enter the arterial intima. See 🔓….
10) It now appears that the passage of #LDL into the #intima is not a merely passive process whereby the concentration in blood & the permeability of the endothelium determine LDL accumulation.
11) It’s #Transcytosis (an active process), through a vesicular pathway involving #caveolae, scavenger receptors (#SRB1) and activin like receptor kinase 1 (#ALK1). Hence for a given blood level of LDL-C the amount of atherosclerosis is variable.
Read 36 tweets
01/ Vous voulez savoir :
- comment se protéger d’une #COVID sévère sans médicaments sur ordonnance ?
- pourquoi elle touche certaines personnes et pas d'autres ?
- ce qui cause les #EffetsSecondaires des #vaccins ?

#COVID_19 #covid19 #covid #coronavirus #vaccination

02/ Jean-Marc Sabatier (@SabatierJeanMa1), Directeur de Recherche au CNRS depuis 32 ans, PhD/HDR en Biochimie et Microbiologie, nous explique tout cela dans une vidéo ( dont je résume les 42 premières minutes dans ce #thread.
03/ Le virus #SARS-CoV-2 s’attaque au #SRA (le système rénine-angiotensine), un de nos systèmes de régulation les plus importants, responsable des fonctions autonomes rénales, pulmonaires, cardiovasculaires, de l’#immunité innée et du #microbiote intestinal.
Read 48 tweets
How long do #neutrophils live? Are they all equal or do they adapt to tissues?
Get answers to these & more questions in our new paper just out online at @CellCellPress!
Led by our fabulous @AndreaRP88 & @ivanbamartin!
Key points in thread 👇…
Neutrophils are almost ubiquitous in the body. At varying levels, but present in almost every tissue
This is a finding in line with our previous work by @Casanova_Acebes @NicolasAvilaJA & Jackson Li @JExpMed 2018
Read 12 tweets
We found unique breast immune cells in the duct walls – ductal macrophages. They remove dying cells, help remodelling + are key players in cancer.

How did we get from this first sighting to finding their identity and function? Follow this thread!
1/n Discovery of mammary ductal macrophagesTissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
The breast contains mammary ducts surrounded by fat, blood vessels, immune + other cells.

We use 3D imaging to investigate the complex relationships b/w these cells to better understand disease.
#microscopy #mammarygland
The ducts form a tree that branches through the breast and blooms and recedes in pregnancy and weaning. These are precancerous mouse ducts, alveoli in lactation and a summary of development in mice.
3/n Precancerous mammary ductsMicroscopic breast alveoli in lactation
Read 43 tweets
Did you know that atherosclerotic lesions are acidic?
Extracellular acidity in atherosclerosis is one of my favorite topics, so I'm really, really excited about this study (2/15)
The authors show that some individuals have carotid atherosclerotic lesions that have an acidic pH. They show this is due to activation of Na+-H+ exchanger in macrophages, which leads to extrusion of H+ and extracellular acidification (3/15)
Read 15 tweets
#Tweetorial time! 🚨 Looks like there’s another misconception about #cholesterol and #atherosclerosis making rounds again. This one has to do with the process of #LDL particles entering the arterial wall. So gather round friends and let me science the s*it out of this 🤓 (1/24)
For background, here’s a widely cited series of figures by Nakashima et al. (2007). They performed autopsies on 38 people aged 7-49, who died of non-#cardiovascular causes (2/24)
Nakashima et al. looked for atherosclerotic lesions at different stages, according to a previously published morphological classification scheme. They found them, took slices, stained them to find #lipids and #macrophages and organized them nicely (3/24)
Read 25 tweets
Wow this is major 👉 In simple terms, infection can change the #electrical properties of #macrophages in a way that eventually directs the white blood cells away from the site of #infection...allowing the escape of the macrophages that contain pathogens
Also, remember this study? 👉 which found that #bacteria in #biofilm communities not only coordinate their own behavior, but also influence the behavior of diverse species at a distance☝️via ion channel mediated long-range electrical signaling:…
And this study 👉 which found that #bacteria in the human gut can generate #electricity☝️The genes that code for this electrical transfer were identified in hundreds of bacterial species, including human pathogens:…
Read 7 tweets

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