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Let’s start with # 1: treating metastatic disease.
Metastasis is when tumor cells grow in a place different from where the primary tumor was found.
Common sites of metastasis for breast cancer (ductal) are liver, bones, lungs, and brain.
Metastasis is when tumor cells grow in a place different from where the primary tumor was found.
Common sites of metastasis for breast cancer (ductal) are liver, bones, lungs, and brain.
People don’t usually die from breast cancer bc they have primary disease, they die because the metastasis has taken over other organs in their body.
For some, chemotherapy or targeted therapies for ER+ and Her2+ can keep the metastatic disease at bay for months or even years.
For some, chemotherapy or targeted therapies for ER+ and Her2+ can keep the metastatic disease at bay for months or even years.
From a biological standpoint, metastasis is a bit of conundrum.
A cell(s?) leave the primary, enter the blood steam, leave the blood stream somewhere else, and set up shop.
This process has many normal checkpoints that should stop it from happening.
📷: semanticscholar.org/paper/The-path…
A cell(s?) leave the primary, enter the blood steam, leave the blood stream somewhere else, and set up shop.
This process has many normal checkpoints that should stop it from happening.
📷: semanticscholar.org/paper/The-path…
Metastatic disease is either
1. de novo - found when the person is diagnosed with cancer
2. recurrent - comes after someone is diagnosed with primary disease
My research focuses on recurrent disease in ER+ breast cancer. We broadly study endocrine resistant breast cancer.
1. de novo - found when the person is diagnosed with cancer
2. recurrent - comes after someone is diagnosed with primary disease
My research focuses on recurrent disease in ER+ breast cancer. We broadly study endocrine resistant breast cancer.
Endocrine resistance occurs when someone either doesn't respond initially or responds and then stops responding to anti-estrogen therapy.
The goal in studying this type of resistance is two-fold:
1) Why does resistance occur?
2) How do we help those who have resistance?
The goal in studying this type of resistance is two-fold:
1) Why does resistance occur?
2) How do we help those who have resistance?
Quick shameless plug: I am chairing the Hormone-Dependent Cancers @GordonConf Seminar this summer! If you know anyone who does research on hormone dependent cancers, tell them about it and suggest they register! #HDCGRS19 #HDCGRC19
grc.org/hormone-depend…
grc.org/hormone-depend…
